Journal
BIOMEDICINES
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10071656
Keywords
sodium-glucose transporter 2 inhibitors; diabetes; heart failure; NT-proBNP; BMI
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Funding
- Mitsubishi Tanabe Pharma Corporation
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There was no significant difference in the effects of canagliflozin, relative to glimepiride, on NT-proBNP concentrations irrespective of baseline obesity. The canagliflozin group was associated with significant reduction in BMI compared to the glimepiride group.
Background: We present results of a 24-week comparative study of the effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor canagliflozin vs. the sulfonylurea glimepiride, by baseline body mass index (BMI), in patients with type 2 diabetes and chronic heart failure. Methods: We conducted a post hoc analysis of the CANDLE trial. This subanalysis evaluated NT-proBNP, BMI, and other laboratory parameters, according to the subgroups stratified by BMI >= 25 kg/m(2) vs. BMI < 25 kg/m(2). Results: A group ratio of proportional changes in the geometric means of NT-proBNP was 0.99 (p = 0.940) for the subgroup with BMI >= 25 kg/m(2) and 0.85 (p = 0.075) for the subgroup with BMI < 25 kg/m(2), respectively. When baseline BMI was modeled as a continuous variable, results for patients with BMI < 30 kg/m(2) showed a slightly smaller increase in NT-proBNP in the canagliflozin group vs. the glimepiride group (p = 0.295); that difference was not seen among patients with BMI >= 30 kg/m(2) (p = 0.948). Irrespective of obesity, the canagliflozin group was associated with significant reduction in BMI compared to the glimepiride group. Conclusion: There was no significant difference in the effects of canagliflozin, relative to glimepiride, on NT-proBNP concentrations irrespective of baseline obesity.
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