Journal
BIOMARKER RESEARCH
Volume 10, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s40364-022-00387-z
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Funding
- National Natural Science Foundation of China [82073090, 82103597]
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This article reviews the role of YAP1 in liver cancer stem cells and its correlation with tumor initiation and progression.
YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study.
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