Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Editorial Material Medicine, General & Internal

Causal Directed Acyclic Graphs

Ari M. Lipsky et al.

Summary: This article discusses the basics of causal directed acyclic graphs, which are useful tools for researchers to communicate their understanding of potential interplay among variables and are commonly used for mediation analysis.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Obstetrics & Gynecology

High birth weight and large-for-gestational-age in singletons born after frozen compared to fresh embryo transfer, by gestational week: a Nordic register study from the CoNARTaS group

A. M. Terho et al.

Summary: This study compares the birth weights of singletons born after frozen embryo transfer (FET) and fresh embryo transfer (fresh ET), finding that FET singletons have higher birth weights starting from gestational week 33 for boys and week 34 for girls, along with differences in risks of large-for-gestational-age and small-for-gestational-age compared to fresh ET.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Growth in children conceived by ART

Maria C. Magnus et al.

Summary: Children conceived by ART are shorter and lighter at birth, but experience more rapid growth and surpass naturally conceived children in height and weight by age 3. However, by age 17, there are no significant differences in height and weight between ART and naturally conceived children.

HUMAN REPRODUCTION (2021)

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Article Public, Environmental & Occupational Health

The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

Angela Pinot de Moira et al.

Summary: The Horizon2020 LifeCycle Project is a cross-cohort collaboration focusing on early-life exposures and later health outcomes. The EU Child Cohort Network, a FAIR data resource, provides core variables for lifecourse research. By harmonising data and using a federated analysis platform, the network aims to increase statistical power, exposure heterogeneity, and accessibility for researchers, promoting cross-cohort comparisons and replication in a wider research community.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

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Article Obstetrics & Gynecology

Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts

Doretta Caramaschi et al.

Summary: This study did not find strong evidence linking medically assisted reproduction with variation in infant blood cell DNA methylation. While some associations were detected in two study cohorts, they were not replicated in another cohort, suggesting the need for further research to identify replicable variation in DNA methylation due to medically assisted reproduction.

HUMAN REPRODUCTION (2021)

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Review Medicine, General & Internal

Diagnosis and Management of Infertility A Review

Sandra Ann Carson et al.

Summary: Approximately 12.7% of reproductive age women in the US seek treatment for infertility each year. Infertility is defined as failure to achieve pregnancy after 12 months of regular unprotected sexual intercourse. Lifestyle factors like smoking and obesity can adversely affect fertility. Ovulatory disorders and male factor infertility are common causes, with polycystic ovary syndrome and unexplained infertility also prevalent. Various treatment options are available, including ovulation induction and in vitro fertilization (IVF), with age being a significant factor in decision-making.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Multidisciplinary Sciences

Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach

Jonathan Yinhao Huang et al.

Summary: The study found that ART-conceived children at the age of 6-6.5 have lower height, weight, skinfold thickness, and blood pressure, but no significant differences in metabolic parameters. These differences are not explained by parental genetics, breastfeeding, or illnesses.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Separating parental and treatment contributions to perinatal health after fresh and frozen embryo transfer in assisted reproduction: A cohort study with within-sibship analysis

Kjersti Westvik-Johari et al.

Summary: Infants conceived by fresh-ET had lower birthweight and increased odds of being small for gestational age, while those conceived by frozen-ET had higher birthweight and increased odds of being large for gestational age. Both fresh-ET and frozen-ET were associated with increased odds of preterm birth. This association was observed within siblings, reducing the likelihood of confounding or selection bias.

PLOS MEDICINE (2021)

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Article Medicine, General & Internal

Cardiovascular disease, obesity, and type 2 diabetes in children born after assisted reproductive technology: A population-based cohort study

Emma Norrman et al.

Summary: A large population-based cohort study in the Nordic countries found that children born after assisted reproductive technology (ART) did not have a significantly different risk of cardiovascular disease or type 2 diabetes compared to children born after spontaneous conception (SC), but had a slightly higher risk of obesity.

PLOS MEDICINE (2021)

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Article Public, Environmental & Occupational Health