Journal
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
Volume 52, Issue 2, Pages 103-118Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S0022093016020010
Keywords
T-cadherin; low-density lipoprotein; adiponectin
Funding
- Russian Scientific Foundation [14-24-00086, 14-35-00026]
Ask authors/readers for more resources
The review discusses structural features of T-cadherin (T-cad) that allow it to perform functions other than cell-cell adhesion. T-cad is a receptor of the significant metabolic components, low-density lipoproteins and high-molecular-weight adiponectin. Association of cardiovascular and metabolic diseases with the T-cad gene polymorphism, as well as predominant T-cad expression in the cardiovascular system, cardioprotection and ischemic limb revascularization, depending on T-cad interaction with adiponectin, suggest a major role of this receptor in vascular and cardiac cell functioning. Possible mechanisms of T-cad-mediated regulation of metabolic processes are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available