Journal
MATERIALS TODAY COMMUNICATIONS
Volume 33, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtcomm.2022.104192
Keywords
Chitosan; Sodium cellulose sulfate; Wound dressing; Antibacterial activity; Cytocompatibility; Wound healing
Categories
Funding
- National Natural Science Foundation of China
- Dalian High-level Talented Person Innovation Support Plan
- Sci- entific Research Funding Project of the Education Department of Liaoning Province
- [21606030]
- [2019RQ118]
- [LJKZ1178]
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A chitosan/sodium cellulose sulfate composite film incorporated with silver nanoparticles was developed for wound dressing. The composite film exhibited a porous structure, excellent antibacterial properties, and a good wound healing effect, indicating its potential application in wound dressing.
Chitosan/sodium cellulose sulfate (CS/NaCS) composite film incorporated with silver nanoparticles (AgNPs) for wound dressing was prepared. Morphology, mechanical properties, porosity, water vapor transmission rate, and water absorption properties of CS/NaCS composite films were investigated. It was demonstrated that the composite film with the CS, NaCS mass ratio of 2:1 had a porous structure with a porosity of 82.40 +/- 1.05 %. The swelling rate and water vapor transmission rate of CN21 composite films were 1670.7 +/- 37.5 % and 1053.8 +/- 19.1 g.m(-2).d(-1), respectively. The CS/NaCS/AgNPs composite film showed excellent antibacterial properties against E. coli and S. aureus. The hemolysis rate of CS/NaCS/AgNPs composite film is less than 5 %, which could be considered to meet the requirements of biomedical materials. In addition, the CS/NaCS/AgNPs composite film exhibited favorable cytocompatibility and the wound closure rate treated by CS/NaCS/AgNPs film reached to 96.17 +/- 1.05 % after 12 days. In other words, the CS/NaCS/AgNPs composite film could promote wound tissue contraction and internal tissue growth, showing a good wound healing effect. Thus the CS/NaCS/AgNPs composite film has potential application in wound dressing.
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