Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 191, Issue -, Pages 87-94Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2016.06.038
Keywords
Caryocar coriaceum wittm; Pequi; Dyslipidemia; Monounsaturated fatty acids; Inflammation; Myeloperoxidase
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Funding
- FUNCAP/BPI
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Caryocar coriaceum Wittm. (Pequi) is found in southern Ceara, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significant reduction in total serum cholesterol and triglycerides, and an increase in HDLC. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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