Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO-CH=CH-. Due to the presence of a reactive alpha,beta-unsaturated carbonyl group, chalcones and their derivatives possess a wide spectrum of antiproliferative, antifungal, antibacterial, antiviral, antileishmanial, and antimalarial pharmacological properties. Recent developments in heterocyclic chemistry have led to the synthesis of chalcone derivatives, which had been biologically investigated toward certain disease targets. The major aspect of this review is to present the most recent synthesis of chalcones bearing N, O, and/or S heterocycles, revealing their biological potential during the past decade (2010-2021). Based on a review of the literature, many chalcone-heterocycle hybrids appear to exhibit promise as future drug candidates owing to their similar or superior activities compared to those of the standards. Thus, this review may prove to be beneficial for the development and design of new potent therapeutic drugs based on previously developed strategies.

Automated summary

This review highlights the recent synthesis of chalcones bearing N, O, and/or S heterocycles and their biological potential. Literature review suggests that these chalcone-heterocycle hybrids show promise as future drug candidates with similar or superior activities compared to standards. This review is of significant importance for the development of new therapeutic drugs based on previously developed strategies.