4.6 Article

Covalent and Noncovalent Loading of Doxorubicin by Folic Acid-Carbon Dot Nanoparticles for Cancer Theranostics

Journal

ACS OMEGA
Volume 7, Issue 27, Pages 23322-23331

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsomega.2c01482

Keywords

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Funding

  1. East Tennessee State University Research Development Committee
  2. NSF [DMR-1752611]
  3. National Institute on Minority Health and Health Disparities, NIMHD-RCMI [2U54MD007595]
  4. Louisiana Cancer Research Center (LCRC)

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In this study, folic acid-conjugated carbon dot nanoparticles were prepared to deliver doxorubicin to cancer cells. These nanoparticles exhibited excellent fluorescence properties and showed promising therapeutic effects.
With special properties such as excellent fluoresce features, low toxicity, good biocompatibility, permeability, and easy clearance from the body, carbon dot (CD)-based nanopartides (NPs) have the potential to deliver drugs and use in vivo diagnostics through molecular imaging. In this work, folic acid-CD (FA-CD) NPs were prepared to deliver doxorubicin (Dox) covalently and noncovalently as cancer theranostics. FA was conjugated to the surface of CDs for targeting cancer cells with overexpressing folate receptors. CDs prepared with various amounts of precursors lead to their associated NPs with different photoluminescence properties and drug release profiles. The loading of Dox and its releasing data depends on the linkage of drug Dox to FA-CD and CD composition. All NPs were characterized by UV-vis, Fourier transform infrared spectroscopy, and dynamic light scattering. The noncovalent FA-CD-Dox NPs were preferred with a simple preparation process, excellent photoluminescence, and in vitro drug release properties. The noncovalent FA-CD-Dox showed the best efficacy against MDA-MB-231 compared to the CD-Dox and covalent FA-CD-Dox.

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