Journal
PLANTS-BASEL
Volume 11, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/plants11151998
Keywords
Sargassum macrocarpum; terpenoids; Sepbox; MAO enzyme inhibitor; molecular docking
Categories
Funding
- Korea Institute of Science and Technology research program [2E31920]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021M3H9A1097889]
- National Research Foundation of Korea [2021M3H9A1097889] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Algae are unique natural products that can produce various types of biologically active compounds. A study found that a certain type of monocyclic terpenoid lactone extracted from brown algae showed potential inhibition of human monoamine oxidases, making it a potential lead compound for the treatment of psychiatric or neurological diseases.
Algae are unique natural products that can produce various types of biologically active compounds. The 70% ethanol extract of brown algae Sargassum macrocarpum collected from the East Sea of Korea inhibited human monoamine oxidases A and B enzymes (hMAO-A and hMAO-B) at a 50 mu g/mL concentration. The bioassay-guided isolation was performed through solid-phase extraction and the Sepbox system followed by serial high-performance liquid chromatography on the reverse phase condition, resulting in the identification of two new monocyclic terpenoid lactones, sargassumins A and B (1 and 2). The planar structures of the compounds were determined by a combination of spectroscopic data. The absolute configurations were determined by the interpretation of circular dichroism data. Compound 1 exhibited mild hMAO-A inhibition (42.18 +/- 2.68% at 200 mu M) and docked computationally into the active site of hMAO-A (-8.48 kcal/mol). Although compound 2 could not be tested due to insufficient quantity, it docked better into hMAO-A (-9.72 kcal/mol). Therefore, the above results suggest that this type of monocyclic terpenoid lactone could be one of the potential lead compounds for the treatment of psychiatric or neurological diseases.
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