Journal
ANTIBIOTICS-BASEL
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics11070845
Keywords
antibiotic residue; solid-phase extraction; LC-MS; MS
Categories
Funding
- Research Impact Fund, University Grants Committee [R7033-18F]
- RGC Theme-based Research Scheme [T21-705/20-N]
- Health and Medical Research Fund Fellowship Scheme [04180077]
- Policy Innovation, and Co-ordination Office of the Government of Hong Kong Special Administrative Region [S2017.A8.005.17S]
- Ntional Natural Science Foundation of China (NSFC)-Research Grant Council (RGC) Joint Research Scheme [N_HKU740/19]
- Welcome Trust [219622/Z/19/Z]
- Wellcome Trust [219622/Z/19/Z] Funding Source: Wellcome Trust
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This study presents a methodology for simultaneous extraction and detection of antibiotic residues in animal and environmental samples. It can qualitatively detect 30 different antibiotics and has the potential for quantification of antibiotic residues.
Detecting and monitoring the usage of antibiotics is a critical aspect of efforts to combat antimicrobial resistance. Antibiotic residue testing with existing LC-MS/MS methods is limited in detection range. Current methods also lack the capacity to detect multiple antibiotic residues in different samples simultaneously. In this study, we demonstrate a methodology that permits simultaneous extraction and detection of antibiotic residues in animal and environmental samples. A total of 30 different antibiotics from 13 classes could be qualitatively detected with our methodology. Further study to reduce analytes' matrix effect would allow for quantification of antibiotic residues.
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