Type-1 Grade 2 Multi-Focal Gastric Neuroendocrine Tumors Secondary to Chronic Autoimmune Gastritis

Background: Chronic autoimmune gastritis (CAG) refers to chronic atrophic gastritis due to autoimmunity. Loss of gastric glands in CAG results in hypergastrinemia and achlorhydria leading to Vitamin B-12 deficiency and hyperplasia of G cells and enterochromaffin-like (ECL) cells. Vitamin B-12 deficiency could cause pernicious anemia and subacute combined degeneration, while G cells and ECL cells hyperplasia might develop gastric neuroendocrine tumor (G-NET). Case Presentation: A 35-year-old Chinese female presented with multi-focal type-1 Grade 2 (G2) NETs with a 14-year history of pernicious anemia and subacute combined degeneration. Conclusion: Here, we report a rare case of a Chinese patient presenting G-NET combined with pernicious anemia and subacute combined degeneration, which are secondary to chronic autoimmune gastritis. This case also illustrates the importance of routine gastroscopy in patients with Vitamin B-12 deficiency.

Automated summary

This article reports a rare case of a Chinese patient who presented with gastric neuroendocrine tumors (G-NET) combined with pernicious anemia and subacute combined degeneration, which are secondary to chronic autoimmune gastritis. This case also highlights the importance of routine gastroscopy in patients with Vitamin B-12 deficiency.