Building Perinatal Pathology Research Capacity in Sub-Saharan Africa

Article Pathology

Pathology Training for Cancer Diagnosis in Africa Perspectives From Two Virtual Courses

Daniel J. L. Seymour et al.

Summary: Virtual training in cancer pathology is a promising tool in Africa, as participants are highly satisfied with the virtual format and have seen improvement in their knowledge during the course.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2022)

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Article Immunology

Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer

Sepideh Dolatshahi et al.

Summary: The study found that the antibody transfer patterns in WHIV women were normal, but there were significant alterations in the antibody profiles of HEU children, driven by the disordered seroprofiles of WHIV. This imbalance was associated with HIV viremia, lower CD4 counts, and postconception ART initiation. Abnormal WHIV antibody profiles were linked to compromised neonatal immunity, highlighting the importance of maternal vaccination interventions to improve antibody transfer to protect HEU children.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Pathology

Strengthening Laboratory Diagnostic Capacity to Support Cancer Care in Uganda

Nixon Niyonzima et al.

Summary: The project successfully enhanced the laboratory diagnostic capacity and service level at the Uganda Cancer Institute through a laboratory improvement process, establishing pathology laboratory, molecular diagnostics laboratory, etc. Improving laboratory diagnostic capacity is crucial for enhancing cancer care in Uganda.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

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Review Developmental Biology

Placental pathology in women with HIV

Nadia M. Ikumi et al.

Summary: Understanding the significance of placental features and their functions is crucial for maternal and neonatal health. In the context of HIV/AIDS and antiretroviral therapy, there is a lack of data on the impact of HIV/ART exposure on placental pathology, emphasizing the need for a more comprehensive approach to diagnosing placental injury.

PLACENTA (2021)

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Article Pathology

Survey of Clinical and Anatomic Pathology Laboratory Infrastructure in Mozambique

Mamudo R. Ismail et al.

Summary: The majority of pathology services in Mozambique are concentrated in the four central hospitals, with a severe imbalance in the population-to-healthcare worker ratio. With only 14 pathologists in the entire country, approximately 35,000 anatomic pathology specimens are evaluated annually. While most pathology services are available, many are limited to the Maputo laboratory.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

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Article Obstetrics & Gynecology

FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction

Nir Melamed et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2021)

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Article Immunology

Placental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus

Lisa M. Bebell et al.

Summary: Women with HIV are at higher risk of adverse birth outcomes, possibly due to placental vasculopathy, but further research is needed to confirm this.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences