☆ 4.6 Article

Stopping of Mycophenolic Acid in Kidney Transplant Recipients for 2 Weeks Peri-Vaccination Does Not Increase Response to SARS-CoV-2 Vaccination-A Non-randomized, Controlled Pilot Study

FRONTIERS IN MEDICINE (2022)

Related references

Note: Only part of the references are listed.

Article Surgery

Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic

Tomas Reischig et al.

Summary: This study found that the protection of SARS-CoV-2 mRNA vaccination against COVID-19 is limited in kidney transplant recipients, with some patients developing COVID-19 after vaccination having lower levels of anti-spike protein IgG. While some patients were able to produce higher IgG levels after COVID-19, overall humoral responses were not significant, leading to suboptimal efficacy post-vaccination.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Add to Collection

Article Medicine, General & Internal

Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients A Randomized Clinical Trial

Roman Reindl-Schwaighofer et al.

Summary: Less than 50% of kidney transplant recipients developed antibodies against the SARS-CoV-2 spike protein after 2 doses of an mRNA vaccine. A third dose of either mRNA or vector vaccine increased antibody response in 39% of KTRs without prior immune response, but neutralizing antibodies and T-cell response remained low. Triple immunosuppression, longer time after transplant, and torque teno virus plasma levels were associated with vaccine response. Local pain was higher with mRNA vaccine, but systemic symptoms were similar between groups.

JAMA INTERNAL MEDICINE (2022)

Add to Collection

Article Surgery

Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients

Marta Kantauskaite et al.

Summary: Kidney transplant recipients (KTRs) have a weaker immune response to SARS-CoV-2 vaccination compared to controls, with mycophenolate mofetil (MMF) treatment being the strongest predictor for impaired response. Adjusting MMF dose may improve the immune response in KTRs.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Add to Collection

Letter Rheumatology

Temporary hold of mycophenolate augments humoral response to SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases: a case series

Caoilfhionn M. Connolly et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Article Medicine, Research & Experimental

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients

Eva Schrezenmeier et al.

Summary: Transplant recipients may have impaired immunity after SARS-CoV-2 vaccination due to immunosuppression caused by mycophenolate (MPA). Temporary MPA hold has been shown to greatly improve the outcomes of booster vaccination in these patients.

JCI INSIGHT (2022)

Add to Collection

Article Surgery

Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus

Ayelet Grupper et al.

Summary: Only 37.5% of transplant recipients developed a positive immune response to the Pfizer vaccine, with lower antibody levels, and factors associated with null immune response include older age, high-dose corticosteroids use, triple immunosuppression maintenance, and regimen with mycophenolate.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Article Infectious Diseases

Antibody response to SARS-CoV-2 mRNA vaccine among kidney transplant recipients: a prospective cohort study

Benaya Rozen-Zvi et al.

Summary: Kidney transplant recipients showed a low antibody response rate of 36.4% after receiving the SARS-CoV-2 mRNA vaccine. Factors associated with antibody response include estimated glomerular filtration rate, medication dosage, age, and calcineurin inhibitor blood level.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Add to Collection

Letter Medicine, General & Internal

Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Letter Surgery

Severe consequences of COVID-19 infection among vaccinated kidney transplant recipients

Noam Tau et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Letter Medicine, General & Internal

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses

Ilies Benotmane et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Surgery

Torque teno virus for risk stratification of graft rejection and infection in kidney transplant recipients-A prospective observational trial

Konstantin Doberer et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Add to Collection

Article Urology & Nephrology

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants

Sophie Caillard et al.

KIDNEY INTERNATIONAL (2020)

Add to Collection

Meeting Abstract Cell Biology

ORAL PRESENTATIONS

Annalisa Gastaldello et al.

HLA (2020)

Add to Collection

Article Urology & Nephrology

A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection

Farsad Eskandary et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Add to Collection

Article Immunology

Three-year observational follow-up of a multicenter, Randomized trial on tacrolimus-based therapy with withdrawal of steroids or mycophenolate mofetil after renal transplant

Julio Pascual et al.

TRANSPLANTATION (2006)

Add to Collection

Article Biochemical Research Methods

Liquid chromatographic method for simultaneous determination of mycophenolic acid and its phenol- and acylglucuronide metabolites in plasma

G Khoschsorur et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2004)

Add to Collection

Article Medicine, Research & Experimental

Azathioprine: old drug, new actions

JS Maltzman et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.