An Atopic Dermatitis-Like Mouse Model by Alternate Epicutaneous Application of Dinitrofluorobenzene and an Extract of Dermatophagoides Farinae

Article Dermatology

TRPV1 mediates itch-associated scratching and skin barrier dysfunction in DNFB-induced atopic dermatitis mice

Liu Tang et al.

Summary: This study demonstrated that cutting off nails or using TRPV1 antagonist, ruthenium red, could alleviate symptoms of atopic dermatitis in mice by reducing clinical severity of dermatitis, IgE and Th2-related cytokine levels, as well as mast cell degranulation. Additionally, scratching behavior, levels of pruritogenic mediators, skin pH and TEWL were significantly decreased, suggesting a reduction in itch-associated scratching and skin barrier defects. The antipruritic effect of nail clipping or RR may be explained by the suppression of TRPV1 activation. These findings indicate the potential of targeting TRPV1 as a therapeutic approach in atopic dermatitis.

EXPERIMENTAL DERMATOLOGY (2022)

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Article Dermatology

The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017

M. R. Laughter et al.

Summary: The global burden of atopic dermatitis (AD) has remained stable from 1990 to 2017, with significant geographical variation among different countries. Lifestyle factors, linked to affluence, are likely important disease drivers, and further development of the GBD methodology is needed to better understand the variations in disease burden related to environmental risk factors.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Dermatology

Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Garrett J. Patrick et al.

Summary: Atopic dermatitis is a common chronic inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to its pathogenesis, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex multidirectional network that can exacerbate atopic skin disease but can also be ameliorated by targeted therapies.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Review Medicine, General & Internal

Atopic Dermatitis

Sonja Staender

Summary: Atopic dermatitis is a chronic condition that typically begins in childhood and can persist into adulthood, with treatment options including both topical and systemic approaches targeting the underlying immune condition.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal