4.6 Article

Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

New Kids on the Block: Bile Salt Conjugates of Microbial Origin

Umran Ay et al.

Summary: The conversion of host bile salts by gut microbes generates secondary bile salt species with distinct biological and physicochemical properties. Recent research has identified a new class of microbial bile salt metabolites that can influence the composition of human gut bacteria and disease states. These microbial bile salt conjugates (MBSCs) are diverse, with almost 50 different species identified.

METABOLITES (2022)

Article Physiology

Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease

Phillip B. Hylemon et al.

Summary: This article describes the complex interactions between diet, the gut microbiome, and bile acids in the development of fatty liver disease. Inflammation appears to be the key driving force in NAFLD/NASH, indicating a potential need for new treatment approaches involving anti-inflammatory compounds and bile acid receptor agonists or antagonists.

COMPREHENSIVE PHYSIOLOGY (2022)

Review Gastroenterology & Hepatology

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

Lulu Sun et al.

Summary: FXR plays a crucial role in metabolic diseases and gastrointestinal and liver cancers by regulating bile acid synthesis and enterohepatic circulation, influencing glucose and lipid homeostasis. Targeting FXR signaling and bile acid metabolites may provide potential strategies for prevention and treatment of gastrointestinal and liver cancers.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Agriculture, Multidisciplinary

Development of a Highly Sensitive Ultra-High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry Quantitation Method for Fecal Bile Acids and Application on Crohn's Disease Studies

Sinah Reiter et al.

Summary: The study introduces a method for quantitating a wide range of bile acids and applies it to investigate the connection between microbiome alterations and bile acid metabolism in Crohn's disease. The research explores the potential use of bile acid profiles to predict disease state in the complex mechanism of Crohn's disease development.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

FXR in liver physiology: Multiple faces to regulate liver metabolism

Katrin Panzitt et al.

Summary: The liver serves as a central metabolic hub that coordinates nutritional inputs and metabolic outputs. FXR in the liver and intestine plays a crucial role in regulating postprandial nutrient disposal. Aside from classical roles, FXR also has effects on amino acid, protein metabolism, autophagic turnover, and inflammation, which are less studied. Additionally, understanding of how FXR signaling is affected by posttranslational modifications and different isoforms is important for potential pharmaceutical targeting in clinical applications.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Article Multidisciplinary Sciences

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Yuko Sato et al.

Summary: Centenarians have a unique gut microbiome enriched in microorganisms capable of producing specific bile acids, including a previously undescribed isoform. The specific bile acid isoalloLCA exhibits potent antimicrobial effects against Gram-positive multidrug-resistant pathogens, suggesting a potential role in reducing infection risk.

NATURE (2021)

Review Microbiology

Review: microbial transformations of human bile acids

Douglas V. Guzior et al.

Summary: Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition. Microbes in the gut modify primary bile acids into diverse forms, and alterations in these secondary bile acids have been linked to various diseases. Recent studies have shown that gut microbiota can conjugate amino acids to bile acids, greatly increasing the diversity of bile acids in mammalian gut.

MICROBIOME (2021)

Article Microbiology

Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids

L. N. Lucas et al.

Summary: Gut bacteria play a critical role in modifying primary bile acids synthesized by the host, leading to the production of secondary bile acids that can regulate metabolic processes and influence gut microbiota composition. Through screening 72 bacterial isolates, this study identified 43 isolates capable of modifying unconjugated bile acids, expanding the known diversity of bacteria involved in bile acid transformations. The discovery of novel microbial conjugated bile acids and previously undescribed species highlights the importance of understanding the interactions between the microbiome, bile acid pool composition, and human health.

MSYSTEMS (2021)

Article Gastroenterology & Hepatology

Albumin in decompensated cirrhosis: new concepts and perspectives

Mauro Bernardi et al.

Article Multidisciplinary Sciences

Global chemical effects of the microbiome include new bile-acid conjugations

Robert A. Quinn et al.

NATURE (2020)

Article Multidisciplinary Sciences

Bile acids drive the newborn's gut microbiota maturation

N. van Best et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

Lisa St John-Williams et al.

SCIENTIFIC DATA (2019)

Article Pharmacology & Pharmacy

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

C. Behr et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

Article

Bile Acid Metabolism in Liver Pathobiology

John Y. L. Chiang et al.

GENE EXPRESSION (2018)

Article Gastroenterology & Hepatology

Association between non-alcoholic fatty liver disease and cancer incidence rate

Gi-Ae Kim et al.

JOURNAL OF HEPATOLOGY (2018)

Review Biochemistry & Molecular Biology

Interactions between gut bacteria and bile in health and disease

Sarah L. Long et al.

MOLECULAR ASPECTS OF MEDICINE (2017)

Review Medicine, General & Internal

Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts

Veronica Urdaneta et al.

FRONTIERS IN MEDICINE (2017)

Article Medical Laboratory Technology

Inter-Laboratory Robustness of Next-Generation Bile Acid Study in Mice and Humans: International Ring Trial Involving 12 Laboratories

Hai T. Pham et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2016)

Review Biochemical Research Methods

Effects of pre-analytical processes on blood samples used in metabolomics studies

Peiyuan Yin et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

Review Gastroenterology & Hepatology

Bile acids and the gut microbiome

Jason M. Ridlon et al.

CURRENT OPINION IN GASTROENTEROLOGY (2014)

Article Food Science & Technology

Targeted metabolite profile of food bioactive compounds by Orbitrap high resolution mass spectrometry: The FancyTiles approach

Antonio Dario Troise et al.

FOOD RESEARCH INTERNATIONAL (2014)

Article Agriculture, Multidisciplinary

Accurate Determination of Reference Materials and Natural Isolates by Means of Quantitative 1H NMR Spectroscopy

Oliver Frank et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Review Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

Gregory A. Michelotti et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)

Article Physiology

Bile Acid Metabolism and Signaling

John Y. L. Chiang

COMPREHENSIVE PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

Juan C. Garcia-Canaveras et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Statistics & Probability

ggplot2

Hadley Wickham

WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL STATISTICS (2011)

Article Biochemical Research Methods

Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry

Carine Steiner et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2010)

Review Biochemistry & Molecular Biology

Bile acids: regulation of synthesis

John Y. L. Chiang

JOURNAL OF LIPID RESEARCH (2009)