4.5 Review

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

The Impact of a Mediterranean Diet on the Gut Microbiome in Healthy Human Subjects: A Pilot Study

Jared J. Rejeski et al.

Summary: This small pilot study demonstrates that the Mediterranean diet can rapidly alter the gut microbiome in healthy subjects at the level of global microbial diversity and individual genera. These findings confirm previous observational studies and establish the feasibility of conducting longer term studies on the impact of the Mediterranean diet on the flora of the GI tract and its relationship to digestive diseases.

DIGESTION (2022)

Review Endocrinology & Metabolism

Neurotransmitter and Intestinal Interactions: Focus on the Microbiota-Gut-Brain Axis in Irritable Bowel Syndrome

Minjia Chen et al.

Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with unknown causes, and disruption in the gut-brain axis is believed to be the cause. Recent studies have shown that neurotransmitters play an important role in IBS, affecting blood flow regulation, intestinal motility, immune system, and gut microbiota. These studies have shed light on the mechanisms of neurotransmitters in the pathogenesis of IBS and provided new therapeutic strategies targeting the nervous system or microbiota.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Gastroenterology & Hepatology

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder

Yating Wan et al.

Summary: The gut microbiome in Chinese children with ASD showed changes in composition, ecological network, and functionality compared to TD children. Novel bacterial markers for predicting ASD were identified and there was evidence of underdevelopment in the gut microbiota of children with ASD compared to their age-matched peers.
Review Clinical Neurology

Gut-Brain Communication in Parkinson's Disease: Enteroendocrine Regulation by GLP-1

Richard A. Manfready et al.

Summary: This review summarizes recent advances in the study of gut-brain communication in Parkinson's disease (PD), focusing on the role of the neuroendocrine system. The importance of the microbiota-gut-brain axis in PD has been highlighted, and GLP-1 hormone secreted by enteroendocrine cells may play a key role in neuroprotection.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2022)

Review Endocrinology & Metabolism

The hypothalamic paraventricular nucleus as a central hub for the estrogenic modulation of neuroendocrine function and behavior

D. Grassi et al.

Summary: This article reviews the roles of estradiol and hypothalamic paraventricular nucleus (PVN) in coordinating reproduction, body physiology, growth, and metabolism. The authors discuss the cyto- and chemo-architecture, connectivity, and function of PVN, as well as the sex-specific regulation exerted by estradiol on PVN neurons and the expression of neurotransmitters, neuromodulators, neuropeptides, and neurohormones in PVN. The study also highlights the importance of classical and non-classical estrogen receptors (ERs) in modulating body homeostasis through PVN.

FRONTIERS IN NEUROENDOCRINOLOGY (2022)

Article Neurosciences

Intestinal Microflora Changes in Patients with Mild Alzheimer's Disease in a Chinese Cohort

Yilin Wang et al.

Summary: This study found that patients with mild AD have specific changes in their gut microbiome, including an increased abundance of the probiotic genus Akkermansia and the traditional probiotic genus Bifidobacteria. These specific AD-associated intestinal microbes could serve as potential targets for early intervention of AD.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Article Neurosciences

Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

Daisuke Asaoka et al.

Summary: This study investigated the effect of the probiotic strain Bifidobacterium breve MCC1274 (A1) on cognitive function and brain atrophy in older patients with mild cognitive impairment (MCI). The results showed that probiotics supplementation improved some aspects of cognitive function and slowed down the progression of brain atrophy, especially in patients with significant atrophy. However, there were no significant changes in the overall composition of the gut microbiota.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Article Neurosciences

Gut dysbiosis and age-related neurological diseases in females

Janelle M. Korf et al.

Summary: In the field of biological research, females have been historically underrepresented. However, with the increasing interest in the gut microbiome and the gut-brain axis, it is important to consider sex as a biological variable. The composition of the gut microbiome is influenced by various factors and differs by age and sex. Dysbiosis in the gut microbiome is believed to impact the development of age-related neurodegenerative disorders. However, most studies only use male animals, even though reproductively senescent females show differences in disease progression, inflammatory responses, and microbiota composition.

NEUROBIOLOGY OF DISEASE (2022)

Review Geriatrics & Gerontology

Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies

Mie Kristine Just et al.

Summary: Pathogenic alpha-synuclein aggregates are a defining feature of neurodegenerative synucleinopathies. Early differentiation between these diseases is challenging due to clinical heterogeneity. However, recent advancements in seed amplification assays and conformation-specific ligand assays show promise in differentiating synucleinopathies.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Editorial Material Behavioral Sciences

Oxytocin Neurons Are Essential in the Social Transmission of Maternal Behavior

Xin Fang et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2022)

Article Genetics & Heredity

Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis

Vicente Navarro-Lopez et al.

Summary: This study analyzed the gut microbiota of patients with RRMS and found differences compared to a healthy control group. Analysis of the microbiota components revealed the potential of certain genera as predictive factors for RRMS prognosis and diagnosis.

GENES (2022)

Review Clinical Neurology

Efficacy and Safety of Diet Therapies in Children With Autism Spectrum Disorder: A Systematic Literature Review and Meta-Analysis

Yuping Yu et al.

Summary: This study examined the efficacy and safety of dietary therapies, including gluten-free, casein-free, and ketogenic diets, for children with Autism Spectrum Disorder (ASD) through a meta-analysis. The results showed that these diet interventions can significantly ameliorate core symptoms of ASD, with gluten-free diets being particularly effective in improving social behaviors. However, more well-designed and high-quality clinical trials are needed to validate these findings due to the limitations of small sample sizes in the included studies.

FRONTIERS IN NEUROLOGY (2022)

Review Cell Biology

Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder

Jiayin Liu et al.

Summary: This review summarized the potential link between gut microbiota dysbiosis and autism spectrum disorder (ASD), and discussed the role of gut microbiota and their metabolites in the onset and progression of ASD. In addition, microbial-based therapeutic interventions were highlighted, with a focus on their potential benefits on behavioral symptoms of ASD. However, further research is needed to clarify the precise contribution of altering gut microbiome to treating core symptoms in ASD.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Microbiology

Microbiota, IgA and Multiple Sclerosis

Leo Boussamet et al.

Summary: Multiple sclerosis (MS) is a neuroinflammatory disease characterized by immune cell infiltration in the central nervous system and destruction of myelin sheaths. Alterations of gut bacteria abundances are present in MS patients. In mouse models, depletion of microbiota results in symptom improvement, while gavage with MS patient microbiota exacerbates the disease and inflammation. Additionally, depletion of B cells is an effective therapy for MS, and recent research suggests a deleterious role of B cells in MS pathology.

MICROORGANISMS (2022)

Article Neurosciences

Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

Hiroshi Nishiwaki et al.

Summary: Random forest models based on gut microbiota can predict the progression of Parkinson's disease in the early stage. Decreases in short-chain fatty acid-producing genera and an increase in mucin-degrading genus are associated with accelerated disease progression. These taxonomic changes are not the consequences of disease progression.

NPJ PARKINSONS DISEASE (2022)

Review Psychology, Multidisciplinary

Overall Rebalancing of Gut Microbiota Is Key to Autism Intervention

Chang Lu et al.

Summary: Autism Spectrum Disorder (ASD) patients have different intestinal microbiota composition from typical children, and rebalancing the microbiota may help improve ASD symptoms. Lactobacillus plantarum may be an effective probiotic, but rebalancing the microbiota through microbiota transfer therapy (MMT) could be more crucial.

FRONTIERS IN PSYCHOLOGY (2022)

Article

Neuropathology of Dementia Disorders

Julie A. Schneider

CONTINUUM Lifelong Learning in Neurology (2022)

Review Medicine, General & Internal

Multiple Sclerosis: Therapeutic Strategies on the Horizon

Ramya Talanki Manjunatha et al.

Summary: This review discusses the pathogenesis, management, and treatment options for multiple sclerosis (MS). The disease is a chronic inflammatory demyelinating disease of the central nervous system, leading to disability in young adults. The understanding of immune pathology has shifted to include role of B cells and microglia/astrocytes in addition to T cells. Effective treatment requires a multidisciplinary approach to handle acute attacks, prevent relapses, and manage symptoms.

CUREUS JOURNAL OF MEDICAL SCIENCE (2022)

Article Immunology

The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention

Na Wu et al.

Summary: This study analyzed the gut microbiota composition of 27 GDM and 30 healthy subjects, identifying specific bacteria associated with GDM, blood glucose levels, and obesity. The study also found that short-term diet management in GDM is associated with changes in specific bacteria, rather than an alternative gut microbial pattern. These findings have important implications for understanding the effects of diet intervention on the gut microbiota and metabolism in pregnant women with GDM.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Clinical Neurology

Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial

Kait F. Al et al.

Summary: This study investigated the safety and tolerability of fecal microbiota transplantation (FMT) in multiple sclerosis (MS) patients and its potential to improve abnormal intestinal permeability. The results showed that FMT was safe and tolerable in this cohort of MS patients, and it could improve elevated small intestinal permeability and induce beneficial alterations to the gut microbiota.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2022)

Article Neurosciences

Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex

Hiroshi Maejima et al.

Summary: This study aimed to investigate the impact of epigenetic treatment with an HDAC inhibitor and aerobic exercise on epigenetic markers and neurotrophic gene expressions in the motor cortex. Findings suggest that HDAC inhibition may offer a more enriched condition for neuroplasticity in the motor cortex, while exercise-induced neurotrophic gene expressions could vary depending on the exercise regimen.

BRAIN RESEARCH (2021)

Article Biochemistry & Molecular Biology

Autism-related dietary preferences mediate autism-gut microbiome associations

Chloe X. Yap et al.

Summary: The study found negligible direct associations between ASD diagnosis and the gut microbiome, but suggested that ASD-related restricted interests may be linked to diet, microbial taxonomic diversity, and stool consistency. The dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency, cautioning against claims that the microbiome has a driving role in ASD.
Article Gastroenterology & Hepatology

The Healthy Microbiome-What Is the Definition of a Healthy Gut Microbiome?

Fergus Shanahan et al.

Summary: Defining a healthy microbiome in different populations is crucial, but requires improved profiling technologies and understanding the variations and influences on the microbiome among apparently healthy individuals.

GASTROENTEROLOGY (2021)

Article Pediatrics

Presenting age and features of females diagnosed with autism spectrum disorder

Jonathan W. Tang et al.

Summary: This study found gender-based differences in clinical features and symptoms of ASD children, with females more likely to show specific symptoms that should be considered in assessment.

JOURNAL OF PAEDIATRICS AND CHILD HEALTH (2021)

Review Geriatrics & Gerontology

The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis

Ting Shen et al.

Summary: This meta-analysis revealed lower abundance levels of Prevotellaceae, Faecalibacterium, and Lachnospiraceae, and higher abundance levels of Bifidobacteriaceae, Ruminococcaceae, Verrucomicrobiaceae, and Christensenellaceae in patients with PD compared to HCs.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Review Immunology

Review: The Role of Intestinal Dysbiosis in Parkinson's Disease

Yiying Huang et al.

Summary: Studies have shown that the gut microbiome plays a crucial role in the pathogenesis of Parkinson's disease, potentially through mechanisms such as inflammation, barrier dysfunction, and microglial activation. Current research focuses on the impact of intestinal dysbiosis in Parkinson's disease, highlighting the importance of factors like inflammation and barrier failure in disease progression. Further investigation, especially clinical studies, are needed to explore the potential therapeutic effects of microbial therapy in Parkinson's disease.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Medicine, General & Internal

Effect of probiotics supplementation on disease progression, depression, general health, and anthropometric measurements in relapsing-remitting multiple sclerosis patients: A systematic review and meta-analysis of clinical trials

Shahrzad Mirashrafi et al.

Summary: This study investigated the effects of probiotics on disease progression, depression, and general health in Multiple Sclerosis patients. The findings showed that probiotics supplementation can improve disease progression and mental health in MS patients, although it had no significant impact on body weight and body mass index. Further research may be needed to confirm these results.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

Review Behavioral Sciences

Altering the gut microbiome to potentially modulate behavioral manifestations in autism spectrum disorders: A systematic review

Camron Davies et al.

Summary: Research indicates that probiotics can help mitigate behavioral manifestations of ASD, with better results found when supplementing multiple probiotic species or prebiotics at the same time.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Engineering, Biomedical

Recent advances in tools to map the microbiome

Hao Shi et al.

Summary: Microbes thrive in diverse habitats, forming ecological niches with rich species diversity and complex spatial structure. Mapping microbial genes, transcripts, and metabolites spatially can provide a better understanding of microbiome structure and function, with significant implications for future microbiome research.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2021)

Review Physiology

FREE FATTY ACID RECEPTORS IN HEALTH AND DISEASE

Ikuo Kimura et al.

PHYSIOLOGICAL REVIEWS (2020)

Review Clinical Neurology

The gut microbiome in neurological disorders

John F. Cryan et al.

LANCET NEUROLOGY (2020)

Article Gastroenterology & Hepatology

Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing

Wen-Jia Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Editorial Material Psychiatry

Gut microbiota: a missing link in psychiatry

Timothy G. Dinan et al.

WORLD PSYCHIATRY (2020)

Review Biochemistry & Molecular Biology

Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies

Mahesh Mohan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Behavioral Sciences

Changes in the Gut Microbiota of Children with Autism Spectrum Disorder

Rong Zou et al.

AUTISM RESEARCH (2020)

Article Psychiatry

Gut microbiota changes in patients with autism spectrum disorders

Xue Ding et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2020)

Article Medicine, General & Internal

Fecal microbiota transplantation therapy for Parkinson's disease A preliminary study

Liu-Jun Xue et al.

MEDICINE (2020)

Review Genetics & Heredity

Understanding the impact of antibiotic perturbation on the human microbiome

D. J. Schwartz et al.

GENOME MEDICINE (2020)

Article Medicine, General & Internal

Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression

Velma T. E. Aho et al.

EBIOMEDICINE (2019)

Article Clinical Neurology

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

Binyin Li et al.

ALZHEIMERS & DEMENTIA (2019)

Article Biochemistry & Molecular Biology

Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis

Qin Zeng et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Clinical Neurology

Gut microbiota in patients with Parkinson's disease in southern China

Aiqun Lin et al.

PARKINSONISM & RELATED DISORDERS (2018)

Article Neurosciences

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model

Carolin Brandscheid et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Psychiatry

Brain-Gut-Microbiota Axis and Mental Health

Timothy G. Dinan et al.

PSYCHOSOMATIC MEDICINE (2017)

Review Neurosciences

Neurophysiology of the Celiac Brain: Disentangling Gut-Brain Connections

Manuela Pennisi et al.

FRONTIERS IN NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

T. Harach et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Gut microbiome alterations in Alzheimer's disease

Nicholas M. Vogt et al.

SCIENTIFIC REPORTS (2017)

Article Infectious Diseases

Clostridium innocuum is a significant vancomycin-resistant pathogen for extraintestinal clostridial infection

J. -H. Chia et al.

CLINICAL MICROBIOLOGY AND INFECTION (2017)

Review Biochemistry & Molecular Biology

Mechanisms and consequences of intestinal dysbiosis

G. Adrienne Weiss et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Neurosciences

Gut microbiota in Parkinson disease in a northern German cohort

Franziska Hopfner et al.

BRAIN RESEARCH (2017)

Article Medicine, Research & Experimental

Analysis of Gut Microbiota in Patients with Parkinson's Disease

V. A. Petrov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Article Multidisciplinary Sciences

Alterations of the human gut microbiome in multiple sclerosis

Sushrut Jangi et al.

NATURE COMMUNICATIONS (2016)

Article Psychiatry

Regulation of prefrontal cortex myelination by the microbiota

A. E. Hoban et al.

TRANSLATIONAL PSYCHIATRY (2016)

Article Immunology

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour

Lieve Desbonnet et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Article Clinical Neurology

Gut Microbiota Are Related to Parkinson's Disease and Clinical Phenotype

Filip Scheperjans et al.

MOVEMENT DISORDERS (2015)

Editorial Material Neurosciences

More than a Gut Feeling: the Microbiota Regulates Neurodevelopment and Behavior

John F. Cryan et al.

NEUROPSYCHOPHARMACOLOGY (2015)

Letter Biochemistry & Molecular Biology

Microbiota is essential for social development in the mouse

L. Desbonnet et al.

MOLECULAR PSYCHIATRY (2014)

Review Neurosciences

Psychobiotics: A Novel Class of Psychotropic

Timothy G. Dinan et al.

BIOLOGICAL PSYCHIATRY (2013)

Article Multidisciplinary Sciences

Gut microbiota composition correlates with diet and health in the elderly

Marcus J. Claesson et al.

NATURE (2012)

Article Multidisciplinary Sciences

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Yun Kyung Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Javier A. Bravo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Microbiology

Pyrosequencing study of fecal microflora of autistic and control children

Sydney M. Finegold et al.

ANAEROBE (2010)

Article Psychiatry

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

Lieve Desbonnet et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2008)

Article Immunology

Gastrointestinal microflora studies in late-onset autism

SM Finegold et al.

CLINICAL INFECTIOUS DISEASES (2002)