4.5 Article

Immunodominant B-Cell Linear Epitope on the VP1 P Domain of a Feline Norovirus Cat Model

Journal

PATHOGENS
Volume 11, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/pathogens11070731

Keywords

norovirus; B-cell epitope; surrogate model; cat

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Funding

  1. JSPS KAKENHI [19K06407]

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This study analyzed the B-cell linear epitope in the P domain of feline norovirus (FNoV) and found that elevated levels of antibodies against this epitope can improve viral shedding and clinical symptoms in FNoV-infected cats. These findings provide important insights into NoV infections in both humans and cats.
Norovirus (NoV) infection remains a major public health concern worldwide. Appropriate animal models are essential for the development of effective NoV vaccines. We previously established the feline NoV (FNoV)-cat model as a surrogate animal model for human NoV infection. In the present study, we analyzed the B-cell linear epitope in the P domain of FNoV to confirm the basic immunological features of the FNoV-cat model. B-cell linear epitopes were present in the P2 subdomain. We compared antibody levels to peptides containing the B-cell linear epitope (P-10) in three FNoV-infected cats with time-course changes in viral load and symptom scoring. After FNoV infection, viral shedding and clinical symptoms were shown to improve by elevated levels of antibodies against P-10 in the plasma. This report provides important information for understanding NoV infections in humans and cats.

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