4.6 Review

Development of Molecular Mechanisms and Their Application on Oncolytic Newcastle Disease Virus in Cancer Therapy

Related references

Note: Only part of the references are listed.
Article Cell Biology

Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells

Yabin Gong et al.

Summary: NDV infection reprograms cell metabolism by increasing glucose utilization, inducing mitochondrial damage and dysfunction, leading to AMPK phosphorylation and MTOR-mediated autophagy.

AUTOPHAGY (2022)

Review Cell & Tissue Engineering

Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy

Chuan-Jing Dai et al.

Summary: The TGF-beta signaling pathway, controlled by Smad4, plays a crucial role in cellular processes and is closely related to the occurrence of diseases, including cancer. However, there is controversy surrounding the regulatory function of Smad4 in tumorigenesis, stem cells, and drug resistance. Smad4 also represents a potential therapeutic target for cancer treatment.

WORLD JOURNAL OF STEM CELLS (2022)

Article Medicine, General & Internal

Cancer statistics in China and United States, 2022: profiles, trends, and determinants

Changfa Xia et al.

Summary: The study compared the latest cancer profiles, trends, and determinants between China and the USA in 2022. China has a higher incidence of lung cancer, while the USA has more cases of breast cancer. Recent years have seen a significant decrease in lung and colorectal cancer rates in the USA, while liver cancer rates have slightly increased. In China, rates for stomach, liver, and esophageal cancer have decreased gradually, but colorectal cancer rates have increased for the whole population.

CHINESE MEDICAL JOURNAL (2022)

Article Oncology

Oncolytic virotherapy: Challenges and solutions

Nasser Hashemi Goradel et al.

Summary: Oncolytic viruses have been explored as cancer therapies since the 19th century, with the observation that they can selectively target cancer cells. Despite progress, challenges such as immune responses and tumor microenvironment issues remain hurdles to overcome.

CURRENT PROBLEMS IN CANCER (2021)

Article Biochemistry & Molecular Biology

NDV-D90 inhibits 17β-estradiol-mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells

Peng Shan et al.

Summary: NDV-D90 promotes apoptosis in breast cancer cells exposed to estrogen by differentially regulating the expression of ER alpha and GPER. It induces apoptosis through intrinsic and extrinsic signaling pathways in ER-positive cells and mainly via intrinsic signaling pathway in ER-negative cells.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

Article Immunology

PD-1 inhibitor combined with apatinib modulate the tumor microenvironment and potentiate anti-tumor effect in mice bearing gastric cancer

Hao Chen et al.

Summary: The study found that the combination of PD-1 inhibitors and apatinib can significantly inhibit tumor growth in mice with gastric cancer, increase levels of CD4(+)T and CD8(+)T cells in tumor tissue, decrease the proportion of MDSCs, and elevate IL-2, IFN-γ, and TNF-α levels. Additionally, combination therapy also increased tumor tissue necrosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Virology

Lithium chloride functions as Newcastle disease virus-induced ER-stress modulator and confers anti-viral effect

Kamal Shokeen et al.

Summary: The study found that lithium chloride can modulate the treatment of Newcastle disease virus infection, reduce endoplasmic reticulum stress, and protect cells from infection impact.

VIRUS RESEARCH (2021)

Article Oncology

Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models

Thomas M. McAusland et al.

Summary: Combining vanadyl sulfate with NDV enhances the anti-neoplastic efficacy by increasing NK cell activation and type I interferon signaling, resulting in rapid tumor regression and long-term cures in mice bearing melanomas. The combination therapy predominantly relies on the innate immune system, with NK cells and type I interferon signaling being important mechanisms of action.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Gastroenterology & Hepatology

HCC surveillance after SVR in patients with F3/F4 fibrosis

George N. Ioannou

Summary: Antiviral treatment for HCV can reduce but not eliminate the risk of HCC in patients, especially those with established cirrhosis who may still require HCC surveillance even after achieving sustained virological response. Strategies for estimating HCC risk such as scoring systems and liver elastography may enable personalized surveillance strategies in the future.

JOURNAL OF HEPATOLOGY (2021)

Review Medicine, Research & Experimental

Recent trends in cancer therapy: A review on the current state of gene delivery

Esam Bashir Yahya et al.

Summary: Cancer treatment has always been a critical issue in clinical practice, with gene therapy showing potential to revolutionize the way different types of cancer are treated. Various approaches, such as targeting microRNAs and CRISPR/Cas9, have been developed for cancer gene therapy. Current research is focusing on exploring different strategies for cancer gene therapy.

LIFE SCIENCES (2021)

Article Biology

Antitumor immunity enhancement through Newcastle viral oncolysate in mice model: A promising method to treat tumors

Amir Sasan Mozaffari Nejad et al.

Summary: Immunization with different titers of NDV lysate significantly reduced tumor volume, enhanced cytotoxic T lymphocyte production and lymphocyte proliferation rates, induced antitumor immune responses through increased IL-4 and IFN-gamma levels, and reduced IL-10 levels.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Oncology

MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells

Ying Liang et al.

Summary: The study revealed that miR-204 plays a critical role in NDV-induced oncolysis in lung cancer cells by regulating the Caspase-3 and Bax pathway. This suggests the potential of utilizing miRs to enhance the oncolytic potency of NDV, with miR-204 identified as a tumor suppressor in NDV-induced oncolysis of lung cancer cells.

ONCOLOGY LETTERS (2021)

Article Microbiology

NDV related exosomes enhance NDV replication through exporting NLRX1 mRNA

Xiaohong Xu et al.

Summary: This study reveals a novel mechanism by which NDV Ex facilitates NDV infection through exporting NLRX1 mRNA to reduce the antiviral capacity of host cells. The research indicates that NDV can manipulate host immune responses through the exosome pathway, utilizing the decrease of NLRX1 mRNA to promote viral replication.

VETERINARY MICROBIOLOGY (2021)

Review Virology

Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances

Amy Kwan et al.

Summary: Oncolytic virotherapy is a promising immunotherapeutic approach for breast cancer, with the potential to overcome the immunogenic cold nature of the tumor. While pre-clinical studies have shown promise, the challenges of monotherapy limitations and specific barriers in the breast cancer population need to be addressed for successful clinical trials.

VIRUSES-BASEL (2021)

Review Virology

Virotherapy in Germany-Recent Activities in Virus Engineering, Preclinical Development, and Clinical Studies

Dirk M. Nettelbeck et al.

Summary: Virotherapy research in Germany focuses on developing and engineering oncolytic viruses for killing cancer cells directly and indirectly through immune responses and therapeutic protein delivery. Clinical trials explore the safety and efficacy of various virotherapeutics in combination therapies, aiming to implement effective treatments in oncology.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

Xiaohong Tan et al.

Summary: The study reveals PAK3 as a downstream effector of Smad4 in promoting metastatic signaling in lung cancer. The Smad4-PAK3 regulation may serve as a potential therapy target for metastatic lung cancer.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis

Xupeng Bai et al.

Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype, and radiotherapy is an effective treatment option. However, acquired radioresistance is a major challenge. The integrated stress response (ISR) pathway is found to be highly activated in radioresistant TNBC cells, with the eIF2 alpha /ATF4 axis proposed as a potential therapeutic target.

REDOX BIOLOGY (2021)

Article Multidisciplinary Sciences

Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells

Xianjin Kan et al.

Summary: Several new cell death processes have been discovered in recent years, with ferroptosis having a tumor-suppressor function and potential for treating therapy-resistant cancers. The mechanism by which ferroptosis mediates the response of tumor cells to oncolytic viruses remains poorly understood. The Newcastle disease virus can induce ferroptosis in tumor cells through the p53-SLC7A11-GPX4 pathway, highlighting the critical role of viruses in killing tumor cells.

ISCIENCE (2021)

Review Medicine, General & Internal

Advances in the Study of Antitumour Immunotherapy for Newcastle Disease Virus

Qiuxing Meng et al.

Summary: NDV plays an important role in cancer therapy by activating the immune system and promoting immune cells' anti-tumor response. Additionally, combining with immune checkpoint inhibitors can enhance the anti-tumor effects and improve patient outcomes.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

Article Biology

Oncolytic Newcastle disease virus reduces growth of cervical cancer cell by inducing apoptosis

Mohsen Keshavarz et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiomics machine-learning signature for diagnosis of hepatocellular carcinoma in cirrhotic patients with indeterminate liver nodules

Fatima-Zohra Mokrane et al.

EUROPEAN RADIOLOGY (2020)

Article Gastroenterology & Hepatology

Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma

Nicole Huge et al.

HEPATOLOGY INTERNATIONAL (2020)

Article Endocrinology & Metabolism

PCOS serum-derived exosomal miR-27a-5p stimulates endometrial cancer cells migration and invasion

Xiaoxia Che et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2020)

Article Cell Biology

Targeting STAT3 enhances NDV-induced immunogenic cell death in prostate cancer cells

Xueke Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Biotechnology & Applied Microbiology

Recent advances of oncolytic virus in cancer therapy

Moumita Mondal et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

Review Biochemistry & Molecular Biology

Engineering and combining oncolytic measles virus for cancer therapy

Mathias F. Leber et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Review Biochemistry & Molecular Biology

Perspective Rational Cancer Treatment Combinations: An Urgent Clinical Need

Julia Boshuizen et al.

MOLECULAR CELL (2020)

Review Cell Biology

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Jae Hyung Park et al.

CELLS (2020)

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biotechnology & Applied Microbiology

Application of CRISPR-Cas9 for Long Noncoding RNA Genes in Cancer Research

Shuai Zhen et al.

HUMAN GENE THERAPY (2019)

Review Oncology

Perspectives on immunotherapy via oncolytic viruses

Alberto Reale et al.

INFECTIOUS AGENTS AND CANCER (2019)

Article Biochemistry & Molecular Biology

Adaptation of the Newcastle Disease Virus to Cell Cultures for Enhancing Its Oncolytic Properties

K. S. Yurchenko et al.

ACTA NATURAE (2019)

Article Cardiac & Cardiovascular Systems

Trends in modes of death in heart failure over the last two decades: less sudden death but cancer deaths on the rise

Pedro Moliner et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Biotechnology & Applied Microbiology

Optimizing oncolytic virotherapy in cancer treatment

Kevin Harrington et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Medicine, General & Internal

Application of Newcastle disease virus in the treatment of colorectal cancer

Hui Song et al.

WORLD JOURNAL OF CLINICAL CASES (2019)

Article Multidisciplinary Sciences

Evaluation of a Recombinant Newcastle Disease Virus Expressing Human IL12 against Human Breast Cancer

Zahiah Mohamed Amin et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Discovery of HSPG2 (Perlecan) as a Therapeutic Target in Triple Negative Breast Cancer

Stephen Kalscheuer et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis

Teridah Ernala Ginting et al.

SCIENTIFIC REPORTS (2019)

Review Biotechnology & Applied Microbiology

Immunotherapy for gastric cancer: dilemmas and prospect

Qingfang Zhao et al.

BRIEFINGS IN FUNCTIONAL GENOMICS (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Cell Biology

Viral strategies for triggering and manipulating mitophagy

Linliang Zhang et al.

AUTOPHAGY (2018)

Review Biochemistry & Molecular Biology

Human Papilloma Virus and Autophagy

Domenico Mattoscio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biotechnology & Applied Microbiology

Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones

Nikolas Tim Martin et al.

MOLECULAR THERAPY (2018)

Article Biotechnology & Applied Microbiology

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy

Jacob M. Ricca et al.

MOLECULAR THERAPY (2018)

Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

Article Pathology

Newcastle Disease Virus Infection in Quail

Leonardo Susta et al.

VETERINARY PATHOLOGY (2018)

Review Gastroenterology & Hepatology

Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma

Fang Huang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Review Oncology

Oncolytic virus immunotherapy: future prospects for oncology

Junaid Raja et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Review Biochemical Research Methods

Mammalian MSC from selected species: Features and applications

Christiane Uder et al.

CYTOMETRY PART A (2018)

Review Radiology, Nuclear Medicine & Medical Imaging

Overview of Breast Cancer Therapy

Tracy-Ann Moo et al.

PET CLINICS (2018)

Review Infectious Diseases

Avian Paramyxovirus: A Brief Review

P. Gogoi et al.

TRANSBOUNDARY AND EMERGING DISEASES (2017)

Article Pharmacology & Pharmacy

Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy

Yunzhou Wu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Gastroenterology & Hepatology

Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer

Mei Huang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Oncology

Oncolytic Viruses in Cancer Treatment A Review

Sean E. Lawler et al.

JAMA ONCOLOGY (2017)

Review Oncology

Oncolytic viral Therapy for Mesothelioma

Daniel F. Pease et al.

FRONTIERS IN ONCOLOGY (2017)

Article Oncology

Proinflammatory response induced by Newcastle disease virus in tumor and normal cells

Teridah Ernala Ginting et al.

ONCOLYTIC VIROTHERAPY (2017)

Review Pharmacology & Pharmacy

Opportunities and challenges in combination gene cancer therapy

Kent L. Nastiuk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Microbiology

Experimental infection with Brazilian Newcastle disease virus strain in pigeons and chickens

Adriano de Oliveira Torres Carrasco et al.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2016)

Review Pharmacology & Pharmacy

Current Challenges in Cancer Treatment

Jon Zugazagoitia et al.

CLINICAL THERAPEUTICS (2016)

Review Infectious Diseases

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Kiril M. Dimitrov et al.

INFECTION GENETICS AND EVOLUTION (2016)

Article Multidisciplinary Sciences

Newcastle Disease Virus V Protein Targets Phosphorylated STAT1 to Block IFN-I Signaling

Xusheng Qiu et al.

PLOS ONE (2016)

Article Medicine, General & Internal

Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer

Kai Liu et al.

MEDICINE (2015)

Review Biochemistry & Molecular Biology

Apoptosis, autophagy, necroptosis, and cancer metastasis

Zhenyi Su et al.

MOLECULAR CANCER (2015)

Review Immunology

Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy

Vinod Vijay Subhash et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

Article Biochemistry & Molecular Biology

Entry of Newcastle Disease Virus into the host cell: Role of acidic pH and endocytosis

Lorena Sanchez-Felipe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

Article Biotechnology & Applied Microbiology

Different responses of human pancreatic adenocarcinoma cell lines to oncolytic Newcastle disease virus infection

P. R. A. Buijs et al.

CANCER GENE THERAPY (2014)

Article Oncology

Recombinant Newcastle Disease virus Anhinga Strain (NDV/Anh-EGFP) for Hepatoma Therapy

Yunzhou Wu et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2014)

Review Virology

Newcastle disease virus: Current status and our understanding

Ketan Ganar et al.

VIRUS RESEARCH (2014)

Review Biotechnology & Applied Microbiology

Newcastle Disease Virus Interaction in Targeted Therapy against Proliferation and Invasion Pathways of Glioblastoma Multiforme

Jafri Malin Abdullah et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Anatomy & Morphology

TRAIL is Involved in the Tumoricidal Activity of Mouse Natural Killer Cells Stimulated by Newcastle Disease Virus in Vitro

De-Zhi Song et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2013)

Article Fisheries

Immune responses of poultry to Newcastle disease virus

Darrell R. Kapczynski et al.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2013)

Article Medicine, Research & Experimental

Newcastle disease virus Malaysian strain AF2240 induces apoptosis in MCF-7 human breast carcinoma cells at an early stage of the virus life cycle

Mohamed Ghrici et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Review Multidisciplinary Sciences

Tumour heterogeneity and cancer cell plasticity

Corbin E. Meacham et al.

NATURE (2013)

Article Oncology

Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy

Christopher A. Alvarez-Breckenridge et al.

ONCOIMMUNOLOGY (2013)

Review Microbiology

Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions

Dmitriy Zamarin et al.

FUTURE MICROBIOLOGY (2012)

Article Biochemistry & Molecular Biology

MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer

Jun Hao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Review Biotechnology & Applied Microbiology

Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy

Han Yuen Lam et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

Article Immunology

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

Mercedes B. Fuertes et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Gastroenterology & Hepatology

Detection of Free Peritoneal Cancer Cells in Gastric Cancer Using Cancer-Specific Newcastle Disease Virus

Joyce Wong et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2010)

Article Virology

Type I Interferon-Sensitive Recombinant Newcastle Disease Virus for Oncolytic Virotherapy

Subbiah Elankumaran et al.

JOURNAL OF VIROLOGY (2010)

Article Biotechnology & Applied Microbiology

Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma

Jennifer Altomonte et al.

MOLECULAR THERAPY (2010)

Article Cell Biology

The Nuclear Factor NF-κB Pathway in Inflammation

Toby Lawrence

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)

Article Biotechnology & Applied Microbiology

Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors

B. Yaacov et al.

CANCER GENE THERAPY (2008)

Article Biotechnology & Applied Microbiology

Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme

AI Freeman et al.

MOLECULAR THERAPY (2006)

Article Gastroenterology & Hepatology

Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive traet

W Liang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2003)

Review Veterinary Sciences

Newcastle disease virus: macromolecules and opportunities

K Yusoff et al.

AVIAN PATHOLOGY (2001)

Review Pharmacology & Pharmacy

Cellular responses to DNA damage

CJ Norbury et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)

Article Biochemistry & Molecular Biology

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

DF Stojdl et al.

NATURE MEDICINE (2000)