Journal
MICROORGANISMS
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms10071294
Keywords
antiviral drugs; coronaviruses; SARS-CoV-2; PEDV; TCM
Categories
Funding
- Science and Technology Program of Guangzhou, China from Department of Science and Technology of Guangdong Province [202206010161]
- Key Research Projects of Universities in Guangdong Province from Department of Education of Guangdong Province [2019KZDXM026]
- Guangdong Major Project of Basic and Applied Basic Research form Guangdong Basic and Applied Basic Research Foundation Committee [2020B0301030007]
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Coronaviruses can cause severe diseases in humans and livestock, and current prevention and control methods include vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines, highlighting the need for new antiviral drugs.
Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respiratory syndrome coronavirus 2 is infecting millions of human beings with high morbidity and mortality worldwide, and the multiplicity of swine epidemic diarrhea coronavirus in swine suggests that coronaviruses seriously jeopardize the safety of public health and that therapeutic intervention is urgently needed. Currently, the most effective methods of prevention and control for coronaviruses are vaccine immunization and pharmacotherapy. However, the emergence of mutated viruses reduces the effectiveness of vaccines. In addition, vaccine developments often lag behind, making it difficult to put them into use early in the outbreak. Therefore, it is meaningful to screen safe, cheap, and broad-spectrum antiviral agents for coronaviruses. This review systematically summarizes the mechanisms and state of anti-human and porcine coronavirus drugs, in order to provide theoretical support for the development of anti-coronavirus drugs and other antivirals.
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