☆ 4.7 Review

Focus on the Contribution of Oxidative Stress in Skin Aging

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Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

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Genetic variants associated with skin aging in the Chinese Han population

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Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition

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The Clinical Potential of Senolytic Drugs

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PLOS ONE (2017)

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Introduction to skin aging

Desmond J. Tobin

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Skin Cancer Epidemics in the Elderly as An Emerging Issue in Geriatric Oncology

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Differential morphological and functional features of fibroblasts explanted from solar lentigo

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Differential effect of extracellular matrix derived from papillary and reticular fibroblasts on epidermal development in vitro

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Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence

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P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

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Reduced DNA methylation patterning and transcriptional connectivity define human skin aging

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Increased oxidative stress in pemphigus vulgaris is related to disease activity and HLA-association

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High glucose-induced reactive oxygen species generation promotes sternness in human adipose-derived stem cells

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The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

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Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure

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CD4, IL-17, and COX-2 Are Associated With Subclinical Inflammation in Malar Melasma

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Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma

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Evaluation of antioxidant enzyme activity and antioxidant capacity in patients with newly diagnosed pemphigus vulgaris

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Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

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Age-Associated Increase in Skin Fibroblast-Derived Prostaglandin E2 Contributes to Reduced Collagen Levels in Elderly Human Skin

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Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

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AGE (2014)

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Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a

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Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin

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Comparative immunohistochemical assessment of cutaneous cyclooxygenase-2 enzyme expression in chronological aging and photoaging

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Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

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How does pheomelanin synthesis contribute to melanomagenesis? Two distinct mechanisms could explain the carcinogenicity of pheomelanin synthesis

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Familial Melanoma-Associated Mutations in p16 Uncouple its Tumor-Suppressor Functions

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Oxidative stress index may play a key role in patients with pemphigus vulgaris

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ADVANCES IN WOUND CARE (2013)

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MC1R expression in HaCaT keratinocytes inhibits UVA-induced ROS production via NADPH Oxidase- and cAMP-dependent mechanisms

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Alpha-Melanocyte-Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes

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1α,25 Dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin

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Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase

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ROS Quenching Potential of the Epidermal Cornified Cell Envelope

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The p16(INK4A) tumor suppressor regulates cellular oxidative stress

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Oxidative stress defense in human-skin-derived mesenchymal stem cells versus human keratinocytes: Different mechanisms of protection and cell selection

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Ultraviolet Irradiation Induces CYR61/CCN1, a Mediator of Collagen Homeostasis, through Activation of Transcription Factor AP-1 in Human Skin Fibroblasts

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Functional MC1R-Gene Variants Are Associated with Increased Risk for Severe Photoaging of Facial Skin

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Linking functional decline of telomeres, mitochondria and stem cells during ageing

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NATURE (2010)

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Inflammatory networks during cellular senescence: causes and consequences

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AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2009)

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α-Melanocyte-Stimulating Hormone Suppresses Bleomycin-Induced Collagen Synthesis and Reduces Tissue Fibrosis in a Mouse Model of Scleroderma Melanocortin Peptides as a Novel Treatment Strategy for Scleroderma?

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Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts

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Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

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Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

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Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

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Progeroid Syndromes and UV-Induced Oxidative DNA Damage

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Matrix-Degrading Metalloproteinases in Photoaging

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Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

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ONCOGENE (2009)

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α-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes

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PIGMENT CELL & MELANOMA RESEARCH (2009)

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Epidermal stem cells are retained in vivo throughout skin aging

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AGING CELL (2008)

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JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2008)

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Influence of therapy on the antioxidant status in patients with melanoma

V. Gadjeva et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2008)

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Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer

Farid Moinfar et al.

MODERN PATHOLOGY (2008)

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Article Multidisciplinary Sciences

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

Solene Mine et al.

PLOS ONE (2008)

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Review Oncology

Can cancer be reversed by engineering the tumor microenvironment?

Donald E. Ingber

SEMINARS IN CANCER BIOLOGY (2008)

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Article Dermatology

Intrinsic and extrinsic factors in skin ageing: a review

M. A. Farage et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2008)

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Article Geriatrics & Gerontology

The skin as a mirror of the aging process in the human organism - State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)

Evgenia Makrantonaki et al.

EXPERIMENTAL GERONTOLOGY (2007)

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Article Dermatology

Interaction of vitamins C and E as better cosmeceuticals

Karen E. Burke

DERMATOLOGIC THERAPY (2007)

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Article Biochemistry & Molecular Biology

Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: More evidence for oxidative stress in vitiligo

K. U. Schallreuter et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Review Dermatology

Merkel cells

Nicholas Boulais et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2007)

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Article Physiology

Ageing and thermal responses during passive heat exposure: sweating and sensory aspects

Andre Dufour et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2007)

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Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo

Maria Lucia Dell'Anna et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Dermatology

Photoprotection by 1,25 dihydroxyvitamin D3 is associated with an increase in p53 and a decrease in nitric oxide products

Ritu Gupta et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Dermatology

Serum chemokine profile in patients with bullous pemphigoid

H. Nakashima et al.

BRITISH JOURNAL OF DERMATOLOGY (2007)

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Review Oncology

Skin ageing and its treatment

L. Baumann

JOURNAL OF PATHOLOGY (2007)

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Review Dermatology

Angiogenesis in skin aging and photoaging

Jin Ho Chung et al.

JOURNAL OF DERMATOLOGY (2007)

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Article Optics

Imaging the mechanical stiffness of skin lesions by in vivo acousto-optical elastography

Sean J. Kirkpatrick et al.

OPTICS EXPRESS (2006)

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Article Cell Biology

p16INK4A is a robust in vivo biomarker of cellular aging in human skin

Sigrun Ressler et al.

AGING CELL (2006)

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Review Cell Biology

Aging and immortality - Quasi-programmed senescence and its pharmacologic inhibition

Mikhail V. Blagosklonny

CELL CYCLE (2006)

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Oncogene-induced cell senescence - Halting on the road to cancer

W. J. Mooi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Article Biochemistry & Molecular Biology

Towards a free radical theory of graying: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage

Petra Clara Arck et al.

FASEB JOURNAL (2006)

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Article Pathology

Decreased collagen production in chronologically aged skin - Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation

J Varani et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Article Biochemistry & Molecular Biology

The importance of the depth distribution of melanin in skin for DNA protection and other photobiological processes

KP Nielsen et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2006)

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Article Dermatology

Multiple senile lentigos of the face, a skin ageing pattern resulting from a life excess of intermittent sun exposure in dark-skinned caucasians: a case-control study

S Monestier et al.

BRITISH JOURNAL OF DERMATOLOGY (2006)

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Review Oncology

The polymerization of melanin: a poorly understood phenomenon with egregious biological implications

R Sarangarajan et al.

MELANOMA RESEARCH (2006)

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Letter Oncology

Re: MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population

MC Fargnoli et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

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Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation

M Brenner et al.

BRITISH JOURNAL OF DERMATOLOGY (2005)

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Article Biochemistry & Molecular Biology

Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

T Nguyen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Multidisciplinary Sciences

BRAFE600-associated senescence-like cell cycle arrest of human naevi

C Michaloglou et al.

NATURE (2005)

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H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo

MH Shin et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2005)

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Article Biochemistry & Molecular Biology

Ultraviolet irradiation induces SMAD7 via induction of transcription factor AP-1 in human skin fibroblasts

TH Quan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Review Cell Biology

Superoxide dismutase evolution and life span regulation

GN Landis et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

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Review Cell Biology

Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders

G Imokawa

PIGMENT CELL RESEARCH (2004)

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BRAF mutations are common somatic events in melanocytic nevi

R Kumar et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)

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Regulation of tyrosinase by tetrahydropteridines and H2O2

JM Wood et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

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Melanocortins in fibroblast biology -: current update and future perspective for dermatology

M Böhm et al.

EXPERIMENTAL DERMATOLOGY (2004)

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Ageing of human epidermis: the role of apoptosis, Fas and telomerase

A Gilhar et al.

BRITISH JOURNAL OF DERMATOLOGY (2004)

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Article Cell Biology

Solar lentigines are strongly related to sun exposure in contrast to ephelides

M Bastiaens et al.

PIGMENT CELL RESEARCH (2004)

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Review Cell Biology

Skin infections and ageing

S Laube

AGEING RESEARCH REVIEWS (2004)

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Skin infections in the elderly

JM Weinberg et al.

DERMATOLOGIC CLINICS (2004)

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Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging

D Van Neste et al.

MICRON (2004)

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Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis

CS Sander et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2004)

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Mechanisms of cell-cycle arrest in Spitz Nevi with constitutive activation of the MAP-kinase pathway

JL Maldonado et al.

AMERICAN JOURNAL OF PATHOLOGY (2004)

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Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities

S Bosset et al.

BRITISH JOURNAL OF DERMATOLOGY (2003)

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Enhanced expression of p16 in seborrhoeic keratosis;: a lesion of accumulated senescent epidermal cells in G1 arrest

S Nakamura et al.

BRITISH JOURNAL OF DERMATOLOGY (2003)

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Review Biochemistry & Molecular Biology

Oxidative DNA damage: mechanisms, mutation, and disease

MS Cooke et al.

FASEB JOURNAL (2003)

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Oxidative stress in malignant melanoma and non-melanoma skin cancer

CS Sander et al.

BRITISH JOURNAL OF DERMATOLOGY (2003)

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Effect of smoking and sun on the aging skin

C Kennedy et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Delayed distribution of active vasodilation and altered vascular conductance in aged skin

JM Pierzga et al.

JOURNAL OF APPLIED PHYSIOLOGY (2003)

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Antioxidant enzyme activity in human stratum corneum shows seasonal variation with an age-dependent recovery

L Hellemans et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Article Biochemistry & Molecular Biology

UVR-induced oxidative stress in human skin in vivo: Effects of oral vitamin C supplementation

F McArdle et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)

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Antioxidants and the response of skin to oxidative stress: Vitamin E as a key indicator

L Packer et al.

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY (2002)

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Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity

C Miracco et al.

BRITISH JOURNAL OF DERMATOLOGY (2002)

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Article Dermatology

Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo

GE Rhie et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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Article Biochemistry & Molecular Biology

Transforming growth factor-β repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3

WH Yuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma

CM Balch et al.

JOURNAL OF CLINICAL ONCOLOGY (2001)

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Matrix metalloproteinase-1 and skin ageing in smokers

C Lahmann et al.

LANCET (2001)

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Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo

JH Chung et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2000)

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Article Biochemistry & Molecular Biology

Age dependent increase of elastase type protease activity in mouse skin - Effect of UV-irradiation

J Labat-Robert et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2000)

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