4.7 Article

Increase of HO-1 Expression in Critically Ill COVID-19 Patients Is Associated with Poor Prognosis and Outcome

Related references

Note: Only part of the references are listed.
Article Respiratory System

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Konstantinos Evangelou et al.

Summary: This study found that SARS-CoV-2 infection in severe COVID-19 patients leads to cellular senescence and a proinflammatory phenotype in AT2 cells. In vitro experiments showed that SARS-CoV-2 infection induces cell senescence and inflammation. Infected senescent cells may contribute to SARS-CoV-2 mutagenesis mediated by APOBEC enzymes.

EUROPEAN RESPIRATORY JOURNAL (2022)

Article Biochemistry & Molecular Biology

Heme oxygenase-1 inhibits DENV-induced endothelial hyperpermeability and serves as a potential target against dengue hemorrhagic fever

Yu-Hsuan Wu et al.

Summary: Dengue virus infection causes vascular pathologies for which there are limited treatment options. Increasing the expression of HO-1 can alleviate pathogenic changes, and compounds such as andrographolide and celastrol can attenuate pathology effects through inducing HO-1 expression.

FASEB JOURNAL (2022)

Article Respiratory System

Clinical importance of serum heme oxygenase-1 measurement in patients with acute exacerbation of idiopathic pulmonary fibrosis triggered by coronavirus disease 2019

Yu Hara et al.

Summary: This article reports a case of a 70-year-old male patient who developed progressive dyspnea after onset of COVID-19 and was diagnosed with acute exacerbation of idiopathic pulmonary fibrosis (IPF) triggered by COVID-19. Despite treatment, there was no improvement in the patient's condition. Ultimately, it was decided to provide best supportive care.

RESPIRATORY MEDICINE CASE REPORTS (2022)

Article Biochemistry & Molecular Biology

HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study

Gerardo Cazzato et al.

Summary: This study examines skin immunopathology in SARS-CoV-2 positive individuals. Results suggest immune deregulation in those who develop various skin manifestations, with increased activation of HMGB-1 and TIM-3 and decreased expression of Heme oxygenase 1 in the skin samples.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Frank A. D. T. G. Wagener et al.

ANTIOXIDANTS (2020)

Article Immunology

Desaturation and heme elevation during COVID-19 infection: a potential prognostic factor of heme oxygenase-1

Wen-Lin Su et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

Article Biochemistry & Molecular Biology

HO-1 mitigates acute kidney injury and subsequent kidney-lung cross-talk

Maxime Rossi et al.

FREE RADICAL RESEARCH (2019)

Article Virology

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Chaker El Kalamouni et al.

VIRUSES-BASEL (2019)

Review Pathology

Modulation of Antiviral Immunity by Heme Oxygenase-1

Janyra A. Espinoza et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

Article Virology

The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication

Lindsay Hill-Batorski et al.

JOURNAL OF VIROLOGY (2013)

Review Medicine, Research & Experimental

Haem oxygenase-I: non-canonical roles in physiology and pathology

Anna Grochot-Przeczek et al.

CLINICAL SCIENCE (2012)

Article Critical Care Medicine

HEME OXYGENASE 1 POLYMORPHISMS AND PLASMA CONCENTRATIONS IN CRITICALLY ILL PATIENTS

Katri Saukkonen et al.

SHOCK (2010)

Article Immunology

Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction

Krishnakumar Devadas et al.

JOURNAL OF IMMUNOLOGY (2006)