Journal
BIOMOLECULES
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biom12081070
Keywords
miRNA; let-7; regulation; aging; aging-related diseases
Categories
Funding
- National Natural Science Foundation of China [32160178, 82160503]
- Project of the Guizhou Provincial Department of Science and Technology [QKH-JC2018-1428, QKHZC-2020-4Y156, QKH-JC-ZK-2022-624]
- Program for New Century Excellent Talents in University of the Ministry of Education of China [NCET-12-0661]
- Collaborative Innovation Center of the Chinese Ministry of Education [2020-39]
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Abnormal regulation and expression of microRNA, especially let-7, are closely related to the aging process and aging-related diseases. Let-7 plays a crucial role in development and is elevated in aging tissues, participating in multiple pathways that regulate aging. Recent studies also suggest that let-7 may be involved in aging by regulating immune function.
The abnormal regulation and expression of microRNA (miRNA) are closely related to the aging process and the occurrence and development of aging-related diseases. Lethal-7 (let-7) was discovered in Caenorhabditis elegans (C. elegans) and plays an important role in development by regulating cell fate regulators. Accumulating evidence has shown that let-7 is elevated in aging tissues and participates in multiple pathways that regulate the aging process, including affecting tissue stem cell function, body metabolism, and various aging-related diseases (ARDs). Moreover, recent studies have found that let-7 plays an important role in the senescence of B cells, suggesting that let-7 may also participate in the aging process by regulating immune function. Therefore, these studies show the diversity and complexity of let-7 expression and regulatory functions during aging. In this review, we provide a detailed overview of let-7 expression regulation as well as its role in different tissue aging and aging-related diseases, which may provide new ideas for enriching the complex expression regulation mechanism and pathobiological function of let-7 in aging and related diseases and ultimately provide help for the development of new therapeutic strategies.
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