Journal
BIOMOLECULES
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biom12070900
Keywords
zinc; zinc homeostasis; intestinal mucosal barrier; inflammatory bowel disease; irritable bowel syndrome; colorectal cancer
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Funding
- National Natural Science Foundation of China [32072750]
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Zinc plays a crucial role in maintaining the normal functions of cells and organisms, as well as the structure and function of the intestinal mucosal barrier. Zinc excess or deficiency, and zinc homeostatic imbalance are associated with intestinal diseases.
Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for the maintenance of the normal physiological functions of cells and organisms. The intestine is the main location for zinc absorption and excretion, while zinc and zinc homeostasis is also of great significance to the structure and function of the intestinal mucosal barrier. Zinc excess or deficiency and zinc homeostatic imbalance are all associated with many intestinal diseases, such as IBD (inflammatory bowel disease), IBS (irritable bowel syndrome), and CRC (colorectal cancer). In this review, we describe the role of zinc and zinc homeostasis in the intestinal mucosal barrier and the relevance of zinc homeostasis to gastrointestinal diseases.
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