Journal
BIOMOLECULES
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/biom12060796
Keywords
pulmonary hypertension; noncoding RNA; long noncoding RNA; circular RNA; therapeutics
Categories
Funding
- GuangDong Basic and Applied Basic Research Foundation [2022A1515012445]
- National Natural Science Foundation of China [82170064]
- Shenzhen Excellent Science and Technology Innovation Talent Development Programme [RCJC20210706091946002]
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This review summarizes the research on the classification, biogenesis, biological functions, and molecular mechanisms of noncoding RNA transcripts involved in pulmonary vascular remodeling in pulmonary hypertension (PH). It highlights the utility and challenges of using these noncoding RNAs as biomarkers and therapeutics in PH.
The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs in the noncoding transcriptome are long noncoding RNAs (lncRNAs) with less circular RNAs (circRNAs), which are two characteristics gaining increasing attention in the forefront of RNA research field. These noncoding transcripts (especially lncRNAs and circRNAs) exert important regulatory functions in PH and emerge as potential disease biomarkers and therapeutic targets. Recent technological advancements have established great momentum for discovery and functional characterization of ncRNAs, which include broad transcriptome sequencing such as bulk RNA-sequence, single-cell and spatial transcriptomics, and RNA-protein/RNA interactions. In this review, we summarize the current research on the classification, biogenesis, and the biological functions and molecular mechanisms of these noncoding RNAs (ncRNAs) involved in the pulmonary vascular remodeling in PH. Furthermore, we highlight the utility and challenges of using these ncRNAs as biomarkers and therapeutics in PH.
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