A Review on the Use of Prostaglandin F2α for Controlling the Estrous Cycle in Mares

Administration of exogenous prostaglandin F-2 alpha (PGF(2 alpha)) to induce luteolysis and return to estrus is the most commonly used method of pharmacologic manipulation of the estrous cycle in mares. The identification of PGF(2 alpha) as the endogenous luteolysin and the luteolytic effects of exogenous hormone administration were demonstrated in the 1970s. After the initial surge in research and information the physiology and pharmacology of PGF(2 alpha), there was a relative lull in investigation of the effects of PGF(2 alpha) administration on ovarian and uterine physiology. However, effects of exogenous PGF(2 alpha) administration on luteal function have received increased attention in the last decade. In particular, studies have shown various responses of the corpus luteum to different protocols (dosage, timing, frequency) of administration, including administration in early diestrus (the refractory period). The current review focuses on our understanding of the various responses of the corpus luteum to PGF(2 alpha), novel approaches to pharmacologically manipulate the equine estrous cycle, and potential applications in veterinary practice. (C) 2016 Elsevier Inc. All rights reserved.