Journal
VACCINES
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/vaccines10060934
Keywords
porcine reproductive and respiratory syndrome virus (PRRSV); PRRSV-1 AUT15-33; respiratory model; weaned piglets; challenge model; modified live virus vaccine
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Funding
- Boehringer Ingelheim Vetmedica GmbH
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This study assessed the efficacy of a modified live PRRSV-1 vaccine in weaned piglets experimentally infected with PRRSV strain AUT15-33. Results showed that vaccination increased average daily weight gain, reduced viral shedding in oral fluids and tissue samples, as well as reduced the severity of lung lesions.
In this study, the efficacy of the commercial modified live PRRSV-1 vaccine Ingelvac PRRSFLEX (R) EU was assessed in weaned piglets experimentally infected with PRRSV strain AUT15-33. Seventy-four weaned piglets were allocated to five groups. Vaccinated (groups 1, 2, and 5) and non-vaccinated piglets (groups 3 and 4), infected with either a low dose (10(3) TCID50 /dose; groups 2 and 4) or a high dose (10(5) TCID50/dose; groups 1 and 3) of the virus, were compared regarding clinical signs, average daily weight gain (ADG), lung lesions, viral load in serum, oral swabs, and tissue samples. In comparison to vaccinated animals, coughing increased notably in the second week after challenge in non-vaccinated piglets. During the same time period, vaccinated, high-dose-infected piglets showed significantly higher ADG (p < 0.05) than non-vaccinated, high-dose-infected animals. All infected piglets reached approximately the same viremia levels, but vaccinated animals showed both a significantly reduced viral load in oral fluid (p < 0.05) and tissue samples and significantly reduced lung lesions (p < 0.05). In conclusion, vaccination was able to increase ADG, reduce the amount of viral shedding via oral fluids, and reduce the severity of lung lesions and the viral load in tissue samples under experimental conditions.
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