☆ 4.7 Article

RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Related references

Note: Only part of the references are listed.

Review Behavioral Sciences

The role of circular RNAs in neuropathic pain

Yi-Li Zheng et al.

Summary: This review discusses the characteristics and functions of circRNAs in neuropathic pain. Through the review of emerging evidence, it is found that deregulation of circRNAs is involved in the development of neuropathic pain and they can modulate downstream gene expression by sponging miRNAs. These findings provide a theoretical basis for the use of circRNAs as biomarkers and therapeutic targets in neuropathic pain.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Add to Collection

Article Gastroenterology & Hepatology

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor

Manon Defaye et al.

Summary: The research explores the mechanisms of chronic abdominal pain in IBD patients, focusing on the role of neuronal activity in microglial activation and visceral hypersensitivity. It suggests that targeting microglial P2Y12 signaling could potentially alleviate pain in patients in remission.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Add to Collection

Article Cell Biology

lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis

Jiacai Dong et al.

Aging-US (2021)

Add to Collection

Article Gastroenterology & Hepatology

Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system

Lena Gottesman-Katz et al.

Summary: Chronic pain is a complex issue with mechanisms that are not fully understood and current treatments being inadequate. Recent studies on G protein-coupled receptors have shed light on potential new approaches for chronic pain management, offering insights into both the structure and function of these receptors. By targeting specific GPCRs and utilizing biased agonists or allosteric modulators, there is promise for developing more effective and targeted therapies for chronic pain in the future.

GUT (2021)

Add to Collection

Article Neurosciences

Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission

Wen-Juan Han et al.

Summary: The study revealed the crucial role of Ttyh1 in pain processing, particularly in acute nociception and pain sensitization caused by peripheral inflammation. Interfering with Ttyh1 specifically in nociceptors can produce comparable pain relief.

NEUROSCIENCE BULLETIN (2021)

Add to Collection

Article Genetics & Heredity

Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Felix Marbach et al.

Summary: This study characterizes the clinical and molecular phenotypes of six individuals with intellectual disability and autism spectrum disorder who carry heterozygous missense variants of the PRKAR1B gene, providing strong evidence for a PRKAR1B-related neurodevelopmental disorder. The de novo origin of PRKAR1B variants was confirmed in five of six individuals, and shared variant c.1003C>T (p.Arg335Trp) was identified in four individuals. Symptoms such as global developmental delay, autism spectrum disorder, and apraxia/dyspraxia were observed in all six individuals, with reduced pain sensitivity found in three of them. Furthermore, PRKAR1B expression in the brain was demonstrated during human embryonal development, and in vitro analyses revealed altered PKA activity in cells transfected with variant-harboring PRKAR1B constructs.

GENETICS IN MEDICINE (2021)

Add to Collection

Article Medicine, Research & Experimental

Downregulation of lncRNA SNHG14 attenuates osteoarthritis by inhibiting FSTL-1 mediated NLRP3 and TLR4/NF-κB pathway through miR-124-3p

Bin Wang et al.

Summary: This study confirmed that downregulation of lncRNA SNHG14 inhibits FSTL-1-mediated activation of NLRP3 and TLR4/NF-kappa B signaling pathway activation by targeting miR-124-3p, thus attenuating inflammatory reactions in OA.

LIFE SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS

Natalia A. Shnayder et al.

Summary: Chronic pain syndromes are a significant medical issue caused by various mechanisms, and standard treatments do not effectively address chronicity. The NO system may play a key role in the development of peripheral pain and its chronicity. Associative genetic studies suggest that genetic variants of NOS genes could be associated with the development and chronicity of peripheral pain.

MOLECULES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Downregulating lncRNA PVT1 Relieves Astrocyte Overactivation Induced Neuropathic Pain Through Targeting miR-186-5p/CXCL13/CXCR5 Axis

Peisong Zhang et al.

Summary: The study found that inhibition of lncRNA PVT1 can alleviate neuropathic pain in SCI rats by upregulating miR-186-5p and down-regulating CXCL13/CXCR5. Mechanism studies confirmed that PVT1 is a competitive endogenous RNA (ceRNA) of miR-186-5p, supporting the potential of the PVT1/miR-186-5p/CXCL13/CXCR5 axis as a new therapeutic target for neuropathic pain.

NEUROCHEMICAL RESEARCH (2021)

Add to Collection

Review Neurosciences

Driving effect of BDNF in the spinal dorsal horn on neuropathic pain

Wu Zhou et al.

Summary: Neuropathic pain is a common symptom of many diseases, and the mechanisms underlying its onset and persistence are unclear, leading researchers to focus on the BDNF signaling pathway in the spinal dorsal horn.

NEUROSCIENCE LETTERS (2021)

Add to Collection

Article Cell Biology

Gene Transcript Alterations in the Spinal Cord, Anterior Cingulate Cortex, and Amygdala in Mice Following Peripheral Nerve Injury

Songxue Su et al.

Summary: This study investigated the changes in gene expression in the spinal cord, anterior cingulate cortex, and amygdala following nerve injury, revealing differentially expressed genes related to neuroinflammation and apoptosis, suggesting potential therapeutic targets for neuropathic pain. The study provides insights into the pathogenic mechanisms underlying neuropathic pain and highlights region-dependent and region-independent alterations in gene expression after injury.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain

Wenli Yu et al.

Summary: The study revealed that Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain, with OIP5 potentially being an ideal drug target for the treatment of such pain.

LIFE SCIENCES (2021)

Add to Collection

Article Genetics & Heredity

Downregulated circular RNA zRANB1 mediates Wnt5a/β-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models

Meng Wei et al.

GENE (2020)

Add to Collection

Article Anesthesiology

The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study

Feihong Jin et al.

EUROPEAN JOURNAL OF PAIN (2020)

Add to Collection

Article Pharmacology & Pharmacy

Long noncoding RNA GAS5 ameliorates chronic constriction injury induced neuropathic pain in rats by modulation of the miR-452-5p/CELF2 axis

Yingjie Tian et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

Add to Collection

Article Neurosciences

TNF in the Trigeminal Nociceptive System Is Critical for Temporomandibular Joint Pain

Qian Bai et al.

MOLECULAR NEUROBIOLOGY (2019)

Add to Collection

Article Nursing

Intranasal Vasopressin Relieves Orthopedic Pain After Surgery

Fu-Juan Yang et al.

PAIN MANAGEMENT NURSING (2019)

Add to Collection

Article Anesthesiology

Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain

Sebastien Sannajust et al.

PAIN (2019)

Add to Collection

Article Medicine, Research & Experimental

Altered expression of itch-related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch

Bao-Wen Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Add to Collection

Article Neurosciences

MiR-30b-5p attenuates oxaliplatin-induced peripheral neuropathic pain through the voltage-gated sodium channel Nav1.6 in rats

Lei Li et al.

NEUROPHARMACOLOGY (2019)

Add to Collection

Review Anesthesiology

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

Megumi Matsuda et al.

JOURNAL OF ANESTHESIA (2019)

Add to Collection

Article Cell Biology

SP1, MYC, CTNNB1, CREB1, JUN genes as potential therapy targets for neuropathic pain of brain

Xue-Tao Yan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Article Neurosciences

NPY2R signaling gates spontaneous and mechanical, but not thermal, pain transmission

Sihan Chen et al.

MOLECULAR PAIN (2019)

Add to Collection

Review Anesthesiology

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Ru-Rong Ji et al.

ANESTHESIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of lncRNA X inactivate-specific transcript ameliorates inflammatory pain by suppressing satellite glial cell activation and inflammation by acting as a sponge of miR-146a to inhibit Na(v)1.7

Wenbo Sun et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Add to Collection

Article Immunology

Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain

Pierre J. Doyen et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Add to Collection

Review Chemistry, Medicinal

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

Andy D. Weyer et al.

PHARMACEUTICALS (2017)

Add to Collection

Article Medicine, Research & Experimental

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons

Yu Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Add to Collection

Article Medicine, Research & Experimental

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model

Ying He et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Article Neurosciences

CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain

Xin Luo et al.

REVIEWS IN THE NEUROSCIENCES (2016)

Add to Collection

Review Biochemistry & Molecular Biology

The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones

Thomas R. Cech et al.

CELL (2014)

Add to Collection

Article Neurosciences

Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression

Shang-Feng Gao et al.

CEREBRAL CORTEX (2013)

Add to Collection

Article Neurosciences

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

Xiuli Zhao et al.

NATURE NEUROSCIENCE (2013)

Add to Collection

Article Pharmacology & Pharmacy

A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C)

Charlotte Brasch-Andersen et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2011)

Add to Collection

Article Pharmacology & Pharmacy

Peripheral antinociceptive effects of μ- and δ-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain

Sergi Leanez et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Add to Collection

© Peeref 2019-2024. All rights reserved.