Emerging roles of long non-coding RNAs in keloids

Keloids are pathologic wound healing conditions caused by fibroblast hyperproliferation and excess collagen deposition following skin injury or irritation, which significantly impact patients by causing psychosocial and functional distress. Extracellular matrix (ECM) deposition and human fibroblast proliferation represents the main pathophysiology of keloid. Long non-coding RNAs (LncRNAs) play important roles in many biological and pathological processes, including development, differentiation and carcinogenesis. Recently, accumulating evidences have demonstrated that deregulated lncRNAs contribute to keloids formation. The present review summarizes the researches of deregulated lncRNAs in keloid. Exploring lncRNA-based methods hold promise as new effective therapies against keloid.

Automated summary

Keloids are pathological wound healing conditions that significantly impact patients by causing psychosocial and functional distress. The main pathophysiology of keloid is the deposition of extracellular matrix (ECM) and proliferation of human fibroblasts. Recent research has shown that deregulated long non-coding RNAs (LncRNAs) contribute to the formation of keloids. Exploring lncRNA-based methods holds promise as new effective therapies against keloids.