Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.941356
Keywords
ADP-ribosylation; ARTs; PAR recognition domain; de-ADP-ribosylating enzymes; post-translational modification
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Funding
- National Natural Science Foundation of China [31970930, 32100936]
- Hubei Provincal Natural Science Foundation Project [2020CFA069, 2018CFB434]
- Hubei Province Education Department Scientific Research Funded Program [Q20211104]
- Neuroscience Team Development Project of Wuhan University of Science and Technology [1180002]
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ADP-ribosylation, a reversible post-translational modification, is tightly regulated by its writers, readers and erasers. It plays critical roles in various physiological and pathological processes. Understanding the major players in the ADP-ribosylation cycle can contribute to research on its function and treatment of associated diseases.
ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we discuss the major players involved in the ADP-ribosylation cycle, which may facilitate the investigation of the ADP-ribosylation function and contribute to the understanding and treatment of ADP-ribosylation associated disease.
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