Related references
Note: Only part of the references are listed.An energetics perspective on geroscience: mitochondrial protonmotive force and aging
Brandon J. Berry et al.
GEROSCIENCE (2021)
Genetic signature of human longevity in PKC and NF-κB signaling
Seungjin Ryu et al.
AGING CELL (2021)
Genetics of extreme human longevity to guide drug discovery for healthy ageing
Zhengdong D. Zhang et al.
NATURE METABOLISM (2020)
UniProt: a worldwide hub of protein knowledge
Alex Bateman et al.
NUCLEIC ACIDS RESEARCH (2019)
CADD: predicting the deleteriousness of variants throughout the human genome
Philipp Rentzsch et al.
NUCLEIC ACIDS RESEARCH (2019)
The Gene Ontology Resource: 20 years and still GOing strong
S. Carbon et al.
NUCLEIC ACIDS RESEARCH (2019)
Hallmarks of Aging: An Autophagic Perspective
Maria Carolina Barbosa et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Human Ageing Genomic Resources: new and updated databases
Robi Tacutu et al.
NUCLEIC ACIDS RESEARCH (2018)
The Reactome Pathway Knowledgebase
Antonio Fabregat et al.
NUCLEIC ACIDS RESEARCH (2018)
Adaptation to metabolic dysfunction during aging: Making the best of a bad situation
S. Michal Jazwinski et al.
EXPERIMENTAL GERONTOLOGY (2018)
Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing
Seungjin Ryu et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2018)
SWISS-MODEL: homology modelling of protein structures and complexes
Andrew Waterhouse et al.
NUCLEIC ACIDS RESEARCH (2018)
Facing up to the global challenges of ageing
Linda Partridge et al.
NATURE (2018)
Report: NIA workshop on translating genetic variants associated with longevity into drug targets
Nicholas J. Schork et al.
GEROSCIENCE (2018)
Ensembl variation resources
Sarah E. Hunt et al.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2018)
Rewiring urea cycle metabolism in cancer to support anabolism
Rom Keshet et al.
NATURE REVIEWS CANCER (2018)
Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes
Simon C. Johnson et al.
HUMAN GENETICS (2017)
LRPPRC-mediated folding of the mitochondrial transcriptome
Stefan J. Siira et al.
NATURE COMMUNICATIONS (2017)
MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome
Julia Wang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2017)
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics
Patrycja Puchalska et al.
CELL METABOLISM (2017)
The loss of LRPPRC function induces the mitochondrial unfolded protein response
Fabian Köhler et al.
Aging-US (2016)
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
Brian K. Kennedy et al.
CELL METABOLISM (2016)
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
Ana Latorre-Pellicer et al.
NATURE (2016)
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance
Alice Matone et al.
PLOS ONE (2016)
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR Study
Frederick E. Dewey et al.
SCIENCE (2016)
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra et al.
SCIENCE (2016)
Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
Jaana A. Hartiala et al.
NATURE COMMUNICATIONS (2016)
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span
Felipe Sierra
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Genetic evidence for common pathways in human age-related diseases
Simon C. Johnson et al.
AGING CELL (2015)
LRPPRC mutations cause early-onset multisystem mitochondrial disease outside of the French-Canadian population
Monika Olahova et al.
BRAIN (2015)
The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle
Carmen Diez-Fernandez et al.
JOURNAL OF GENETICS AND GENOMICS (2015)
A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome
Julie Thompson Legault et al.
CELL REPORTS (2015)
Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome
Florin Sasarman et al.
HUMAN MOLECULAR GENETICS (2015)
The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource
Thomas Craig et al.
NUCLEIC ACIDS RESEARCH (2015)
OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders
Joanna S. Amberger et al.
NUCLEIC ACIDS RESEARCH (2015)
Track data hubs enable visualization of user-defined genome-wide annotations on the UCSC Genome Browser
Brian J. Raney et al.
BIOINFORMATICS (2014)
Geroscience: Linking Aging to Chronic Disease
Brian K. Kennedy et al.
CELL (2014)
The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation?
Christopher F. Bennett et al.
EXPERIMENTAL GERONTOLOGY (2014)
The paradox of mitochondrial dysfunction and extended longevity
Erin Munkacsy et al.
EXPERIMENTAL GERONTOLOGY (2014)
A general framework for estimating the relative pathogenicity of human genetic variants
Martin Kircher et al.
NATURE GENETICS (2014)
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
Christopher F. Bennett et al.
NATURE COMMUNICATIONS (2014)
COMPARTMENTS: unification and visualization of protein subcellular localization evidence
Janos X. Binder et al.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2014)
Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts
Chad Lerner et al.
AGING CELL (2013)
Ketone body metabolism and cardiovascular disease
David G. Cotter et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)
Mitochondrial Dysfunction in Aging and Longevity: A Causal or Protective Role?
Daniel A. Pulliam et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud et al.
CELL (2013)
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Masahiro Morita et al.
CELL METABOLISM (2013)
mTOR is a key modulator of ageing and age-related disease
Simon C. Johnson et al.
NATURE (2013)
Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H. Houtkooper et al.
NATURE (2013)
Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing
Jeehae Han et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2013)
ENCODE Data in the UCSC Genome Browser: year 5 update
Kate R. Rosenbloom et al.
NUCLEIC ACIDS RESEARCH (2013)
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion
Stephane G. Rolland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Yun Chen et al.
SCIENCE (2013)
Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging
Hyun-Woo Rhee et al.
SCIENCE (2013)
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dao-Fu Dai et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences
Hideo Takakusa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Mitochondria and Organismal Longevity
Ara B. Hwang et al.
CURRENT GENOMICS (2012)
Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
Stacy L. Andersen et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)
Genetic Signatures of Exceptional Longevity in Humans
Paola Sebastiani et al.
PLOS ONE (2012)
Contemporary human genetic strategies in aging research
Cinnamon S. Bloss et al.
AGEING RESEARCH REVIEWS (2011)
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
Cagdas Tazearslan et al.
AGING CELL (2011)
Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel
Abel Gonzalez-Perez et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
Michael C. Wu et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
Kirstin Mittelstrass et al.
PLOS GENETICS (2011)
Mining protein loops using a structural alphabet and statistical exceptionality
Leslie Regad et al.
BMC BIOINFORMATICS (2010)
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship
Olga Martins de Brito et al.
EMBO JOURNAL (2010)
Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase
Satu Pekkala et al.
BIOCHEMICAL JOURNAL (2009)
Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain
Jeffrey M. Copeland et al.
CURRENT BIOLOGY (2009)
Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study
Rudi G. J. Westendorp et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2009)
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Camille C. Caldeira da Silva et al.
AGING CELL (2008)
Shifting paradigm of association studies: Value of rare single-nucleotide polymorphisms
Ivan P. Gorlov et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Mitofusin 2 Builds a Bridge between ER and Mitochondria
Carsten Merkwirth et al.
CELL (2008)
A mitochondrial protein compendium elucidates complex I disease biology
David J. Pagliarini et al.
CELL (2008)
Human carbamoyl-phosphate synthetase:: Insight into N-acetylglutamate interaction and the functional effects of a common single nucleotide polymorphism
V. Ahuja et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2008)
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
NATURE (2008)
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Yousin Suh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Stereochemical criteria for prediction of the effects of proline mutations on protein stability
Kanika Bajaj et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
High-resolution design of a protein loop
Xiaozhen Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Survival of parents and siblings of supercentenarians
Thomas Perls et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)
Successful aging: From phenotype to genotype
Stephen J. Glatt et al.
BIOLOGICAL PSYCHIATRY (2007)
Transgenic mice with a reduced core body temperature have an increased life span
Bruno Conti et al.
SCIENCE (2006)
Mitochondrial DNA involvement in human longevity
Aurelia Santoro et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
Mitochondria: Dynamic organelles in disease, aging, and development
David C. Chan
CELL (2006)
Mechanisms of Disease: a molecular genetic update on hereditary axonal neuropathies
S Zuchner et al.
NATURE CLINICAL PRACTICE NEUROLOGY (2006)
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study
M Schoenmaker et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2006)
The exchangeability of amino acids in proteins
LY Yampolsky et al.
GENETICS (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Extension of murine life span by overexpression of catalase targeted to mitochondria
SE Schriner et al.
SCIENCE (2005)
Decline in skeletal muscle mitochondrial function with aging in humans
KR Short et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Clinical phenotype of families with longevity
G Atzmon et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2004)
mTOR integrates amino acid- and energy-sensing pathways
C Tokunaga et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring
DF Terry et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2004)
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
G Morrow et al.
FASEB JOURNAL (2004)
Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila
G Morrow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Unique lipoprotein phenotype and genotype associated with exceptional longevity
N Barzilai et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
The amino-acid mutational spectrum of human genetic disease
D Vitkup et al.
GENOME BIOLOGY (2003)
Rates of behavior and aging specified by mitochondrial function during development
A Dillin et al.
SCIENCE (2002)
Life-long sustained mortality advantage of siblings of centenarians
TT Perls et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The human genome browser at UCSC
WJ Kent et al.
GENOME RESEARCH (2002)
Paradoxes in longevity:: sequence analysis of mtDNA haplogroup J in centenarians
G Rose et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2001)
Offspring of centenarians have a favorable lipid profile
N Barzilai et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2001)
In vivo control of respiration by cytochrome C oxidase in human cells
G Villani et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes
JZ Zhang
JOURNAL OF MOLECULAR EVOLUTION (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)