4.3 Article

High-fat diet affects autophagy and mitochondrial compartment in rat Harderian gland

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Altered Mitochondrial Quality Control in Rats with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Induced by High-Fat Feeding

Federica Cioffi et al.

Summary: This study investigates the effects of a long-term high-fat diet on mitochondrial quality control in a rodent model of metabolic dysfunction-associated fatty liver disease (MAFLD). The results show that the high-fat diet leads to increased mitochondrial reactive oxygen species production, mitochondrial DNA damage, and reduced mitochondrial biogenesis, mtDNA copy numbers, mtDNA repair, and mitochondrial fusion, as well as impaired mitophagy.

GENES (2022)

Review Biochemistry & Molecular Biology

Molecular mechanisms and physiological functions of mitophagy

Mashun Onishi et al.

Summary: Mitophagy is a fundamental cellular mechanism for degrading mitochondria, regulated by specific receptors or ubiquitin molecules. Its dysfunction is associated with various pathological conditions, highlighting its biological significance in maintaining cellular homeostasis.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age

Xiao-Tong Kong et al.

Summary: The study found that autophagy and apoptosis in the Harderian gland of striped dwarf hamsters vary with age, with differences in HG weight and mitochondrial function between sexes likely related to apoptosis. Apoptosis mainly affects growth and development in the HG, while autophagy impacts aging.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2021)

Article Endocrinology & Metabolism

Short-Term High-Fat Feeding Does Not Alter Mitochondrial Lipid Respiratory Capacity but Triggers Mitophagy Response in Skeletal Muscle of Mice

Sarah E. Ehrlicher et al.

Summary: The study found that a high-fat diet stimulates upstream activation of skeletal muscle mitophagy without altering mitochondrial respiration. This suggests that lipid-induced oxidative stress may be involved in this process.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Biochemistry & Molecular Biology

Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model

Adrian Santos-Ledo et al.

Summary: The use of melatonin in a metabolic syndrome model showed promising effects in improving lipid metabolism through autophagic induction, particularly in the impaired Harderian gland. This suggests that melatonin may be a potential treatment for metabolic syndrome by improving oxidative homeostasis.

ANTIOXIDANTS (2021)

Article Gastroenterology & Hepatology

A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis

Marina Garcia-Macia et al.

Summary: This study investigated the molecular mechanisms of liver lipophagy in NAFLD. It was found that mTORC1 phosphorylates Plin3 to promote LD degradation, suggesting a potential therapeutic strategy for enhancing lipophagy in hepatocytes to protect against lipid-mediated toxicity in NAFLD.

HEPATOLOGY (2021)

Article Physiology

High-Fat Diet Increased Oxidative Stress and Mitochondrial Dysfunction Induced by Renal Ischemia-Reperfusion Injury in Rat

Priyanka N. Prem et al.

Summary: High-fat diet consumption can induce renal lipotoxicity and metabolic dyshomeostasis, compromising kidney function and exacerbating renal ischemia-reperfusion injury.

FRONTIERS IN PHYSIOLOGY (2021)

Article Endocrinology & Metabolism

3,5-Diiodo-L-Thyronine (T2) Administration Affects Visceral Adipose Tissue Inflammatory State in Rats Receiving Long-Lasting High-Fat Diet

Giuseppe Petito et al.

Summary: This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Ophthalmology

High-Fat Diet Induces Inflammation of Meibomian Gland

Jinghua Bu et al.

Summary: High-fat diet-induced declines in PPAR-gamma expression and activation of MAPK and NF-kappa B signaling pathways may lead to meibomian gland inflammation and dysfunction in mice, characterized by lipid accumulation, inflammatory cell infiltration, apoptosis, and mitochondria damage. Treatment involving dietary shifts and medication administration can alleviate this inflammation.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Review Medicine, Research & Experimental

Selective autophagy of intracellular organelles: recent research advances

Wen Li et al.

Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.

THERANOSTICS (2021)

Article Pathology

High-Fat Diet-Induced Functional and Pathologic Changes in Lacrimal Gland

Xin He et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

Article Endocrinology & Metabolism

The Harderian gland: Endocrine function and hormonal control

Alessandra Santillo et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2020)

Article Biology

StAR protein and steroidogenic enzyme expressions in the rat Harderian gland

Sara Falvo et al.

COMPTES RENDUS BIOLOGIES (2018)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics: overview of molecular mechanisms

Lisa Tilokani et al.

MITOCHONDRIAL DISEASES (2018)

Review Nutrition & Dietetics

Potential roles of vitamin E in age-related changes in skeletal muscle health

Eunhee Chung et al.

NUTRITION RESEARCH (2018)

Article Pharmacology & Pharmacy

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe212/Nrf2 and mitochondria

In-geun Ryoo et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

DNA polymerases in the mitochondria: A critical review of the evidence

Rachel Krasich et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Article Nutrition & Dietetics

Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats

Federica Cioffi et al.

NUTRIENTS (2017)

Review Biochemistry & Molecular Biology

Mitochondrial fission and fusion

Hakjoo Lee et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2016)

Article Cell Biology

Autophagic and proteolytic processes in the Harderian gland are modulated during the estrous cycle

M. Garcia-Macia et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2014)

Review Cell Biology

Self-consumption: the interplay of autophagy and apoptosis

Guillermo Marino et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Genetics & Heredity

DNA repair mechanisms in dividing and non-dividing cells

Teruaki Iyama et al.

DNA REPAIR (2013)

Article Endocrinology & Metabolism

Triiodothyronine induces lipid oxidation and mitochondrial biogenesis in rat Harderian gland

A. Santillo et al.

JOURNAL OF ENDOCRINOLOGY (2013)

Review Biochemistry & Molecular Biology

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

Richard C. Scarpulla

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Biochemical Research Methods

Effect of D-aspartate uptake on uncoupling protein-3 and α-tubulin expressions in rat Harderian gland

Alessandra Santillo et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

D-Aspartate binding sites in rat Harderian gland

Marcello Di Giovanni et al.

AMINO ACIDS (2010)

Review Biochemistry & Molecular Biology

Superoxide dismutases-a review of the metal-associated mechanistic variations

Isabel A. Abreu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Biochemistry & Molecular Biology

A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

Chuang-Rung Chang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

d-Aspartate affects secretory activity in rat Harderian gland: molecular mechanism and functional significance

Rossella Monteforte et al.

AMINO ACIDS (2009)

Article Cell Biology

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator

Richard C. Scarpulla

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

Article Biochemistry & Molecular Biology

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Gilad Twig et al.

EMBO JOURNAL (2008)

Article Biology

Morphological and biochemical changes in the Harderian gland of hypothyroid rats

Rossella Monteforte et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2008)

Review Multidisciplinary Sciences

Novel function of lipids as a pheromone from the Harderian gland of golden hamster

Yousuke Seyama et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2007)

Article Education, Scientific Disciplines

PGC-1α:: a key regulator of energy metabolism

Huiyun Liang et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2006)

Article Biochemistry & Molecular Biology

Survival mechanisms in a physiological oxidative stress model

C Tomás-Zapico et al.

FASEB JOURNAL (2005)

Article Biochemistry & Molecular Biology

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

HC Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Presence of interaction but not complementation between human mtDNAs carrying different mutations within a tRNALeu(UUR) gene

T Ono et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Biochemistry & Molecular Biology

DNA polymerase gamma, the mitochondrial replicase

LS Kaguni

ANNUAL REVIEW OF BIOCHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Nuclear activators and coactivators in mammalian mitochondrial biogenesis

RC Scarpulla

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2002)

Article Biochemistry & Molecular Biology

Physiological oxidative stress model:: Syrian hamster Harderian gland -: Sex differences in antioxidant enzymes

A Coto-Montes et al.

FREE RADICAL BIOLOGY AND MEDICINE (2001)