Determination of the Optimal Level of Dietary Zinc for Newly Weaned Pigs: A Dose-Response Study

Simple Summary Piglets have a very low feed intake immediately after weaning. We hypothesise that the EU-legislated maximum dietary zinc concentration (150 mg zinc/kg diet) will increase the risk of zinc deficiency after weaning. Zinc deficiency includes symptoms such as impaired growth and increased risk of diarrhoea. However, a high dietary zinc concentration has an antimicrobial effect on the bacteria and increases the risk of antimicrobial resistance. The findings of this study show that the dietary zinc level had a quadratic effect on growth, with a turning point at an approximately 1400 mg zinc per kg diet. The risk of diarrhoea increased up to 60% for pigs that had a blood zinc concentration which decreased after weaning. Maintaining the blood zinc concentration seven days after weaning required up to 1121 mg zinc per kg diet. There was no evidence for an antimicrobial effect when feeding pigs a diet with up to 1601 mg zinc per kg. One hundred and eighty individually housed piglets with an initial body weight of 7.63 +/- 0.98 kg (at 28 days of age) were fed a diet containing either 153, 493, 1022, 1601, 2052 or 2407 mg zinc/kg (added Zn as zinc oxide; ZnO) from day 0-21 post weaning to determine the optimal level of Zn for weaned piglets. Body weight, feed intake and faecal scores were recorded, and blood and faecal samples were collected. Dietary Zn content quadratically affected both feed intake and gain in the first two weeks, with an approximately 1400 mg Zn/kg diet and a Zn intake of 400 mg/day as the optimal levels. The relative risk of diarrhoea increased up to 60% at day 7 and 14 if serum Zn status dropped below the weaning level (767 mu g/L), and maintain the weaning serum Zn status required approximately 1100 mg Zn/kg (166 mg Zn/day) during week 1. Blood markers of intestinal integrity (D-lactate and diamine oxidase) were unaffected by dietary Zn, and dietary Zn levels of 1022 and 1601 mg/kg did not affect the faecal numbers of total bacteria, Lactobacilli and E. Coli bacteria compared to 153 mg Zn/kg. These results indicate that the requirement for Zn in newly weaned piglets may be substantially higher than currently assumed.

Automated summary

This study suggests that the maximum dietary zinc concentration regulated by the EU may increase the risk of zinc deficiency and related health issues in piglets after weaning. High dietary zinc levels have both antimicrobial effects and an increased risk of antimicrobial resistance. The findings also indicate that the actual zinc requirement for newly weaned piglets may be higher than previously assumed.