Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 9, Issue 8, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofac379
Keywords
immunocompromised host; nontuberculous mycobacteria; pulmonary infection; transfection
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Funding
- National Medical Research Council (NMRC), Singapore
- Aspiration Grant
- National University Health System
- Clinician ScientistIndividual Research Grant-New Investigator Grant (CS-IRG-NIG) from NMRC, Singapore.
- Alexandra Hospital
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The TRAF3 R338W variant is found to be associated with recurrent PNTM infection, and TRAF3 and TNF-alpha deficiencies are demonstrated through ex vivo immune and cloning-transfection cellular studies.
Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-alpha-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.
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