Supramolecular Adhesive Materials with Antimicrobial Activity for Emerging Biomedical Applications

Traditional adhesives or glues such as cyanoacrylates, fibrin glue, polyethylene glycol, and their derivatives have been widely used in biomedical fields. However, they still suffer from numerous limitations, including the mechanical mismatch with biological tissues, weak adhesion on wet surfaces, biological incompatibility, and incapability of integrating desired multifunction. In addition to adaptive mechanical and adhesion properties, adhesive biomaterials should be able to integrate multiple functions such as stimuli-responsiveness, control-releasing of small or macromolecular therapeutic molecules, hosting of various cells, and programmable degradation to fulfill the requirements in the specific biological systems. Therefore, rational molecular engineering and structural designs are required to facilitate the development of functional adhesive materials. This review summarizes and analyzes the current supramolecular design strategies of representative adhesive materials, serving as a general guide for researchers seeking to develop novel adhesive materials for biomedical applications.

Automated summary

Traditional adhesives have been widely used in biomedical fields, but they have limitations such as mechanical mismatch with biological tissues and weak adhesion on wet surfaces. Therefore, rational molecular engineering and structural designs are necessary to develop functional adhesive materials that can meet the specific requirements in biological systems.