Related references
Note: Only part of the references are listed.Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13
Mariangela Agamennone et al.
CHEMMEDCHEM (2016)
A Recent Perspective on Discovery and Development of Diverse Therapeutic Agents Inspired from Isatin Alkaloids
Rajesh A. Rane et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
Dilan Ozmen Ozgun et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)
Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases
Gang Chen et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2016)
Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors
Mohsen Tavari et al.
MEDCHEMCOMM (2016)
Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6
Angela Corona et al.
PLOS ONE (2016)
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase
Rita Meleddu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection
Nicolas Sluis-Cremer et al.
FUTURE MICROBIOLOGY (2015)
Synthesis and fluorine-mediated interactions in methanol-encapsulated solid state self-assembly of an isatin-thiazoline hybrid
Humayun Pervez et al.
JOURNAL OF MOLECULAR STRUCTURE (2015)
Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives
Angela Corona et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Polypharmacology: the rise of multitarget drugs over combination therapies
Michela Rosini
FUTURE MEDICINAL CHEMISTRY (2014)
Polypharmacology: Challenges and Opportunities in Drug Discovery
Andrew Anighoro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors
Simona Distinto et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective
Aurelie Bornot et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity
Virginie Suchaud et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach
Simona Distinto et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies
Anthony K. Felts et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket
Kalyan Das et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?
Youcef Mehellou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Design Strategies of Novel NNRTIs to Overcome Drug Resistance
Peng Zhan et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Conformational Landscape of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Non-Nucleoside Inhibitor Binding Pocket: Lessons for Inhibitor Design from a Cluster Analysis of Many Crystal Structures
Kristina A. Paris et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
Daniel M. Himmel et al.
STRUCTURE (2009)
Initiating therapy: When to start, what to use
Martin S. Hirsch
JOURNAL OF INFECTIOUS DISEASES (2008)
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
Kalyan Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Ensemble docking of multiple protein structures: Considering protein structural variations in molecular docking
Sheng-You Huang et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Designed multiple ligands. An emerging drug discovery paradigm
R Morphy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Importance of accurate charges in molecular docking: Quantum mechanical/molecular mechanical (QM/MM) approach
AE Cho et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
K Das et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2005)
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
JD Pata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models
PA Kollman et al.
ACCOUNTS OF CHEMICAL RESEARCH (2000)
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding
JS Ren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
