Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.922332
Keywords
Copper-induced cell death; cuproptosis; lung cancer; tumor microenvironment; immunotherapy sensitivity; chemotherapy sensitivity; clinical outcomes
Categories
Funding
- Research Center of Clinical Medicine of Affiliated Hospital of Nantong University, Nantong, China
Ask authors/readers for more resources
This study analyzed the role of copper-induced cell death in the diagnosis and treatment of lung adenocarcinoma (LUAD) and identified a cupLA panel that is associated with the risk of LUAD occurrence and clinicopathological features. It can guide clinicians in refining LUAD subtypes and making treatment choices.
Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced cell death have been investigated, yet few showed promising therapeutic effects in clinical trials. In March 2022, Science first introduced the concept and mechanisms of cuproptosis, suggesting that copper-induced cell death targets the tricarboxylic acid (TCA) cycle via protein lipoylation. Does this novel form of cell death take part in tumorigenesis or tumor progression? Is cuproptosis related to clinical outcomes of diseases? Is there a cuproptosis-related panel for clinical practice in cancer treatment? Herein, based on 942 samples of lung adenocarcinoma (LUAD), we analyzed on gene set level the existence and predictive value of cuproptosis in disease diagnosis and treatment. We screened out and identified the cupLA panel which indicates the risk of LUAD occurrence, clinicopathological features of LUAD patients, and could guide clinicians to refine LUAD subtypes and make treatment choices.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available