A Novel Prognostic Signature Associated With the Tumor Microenvironment in Kidney Renal Clear Cell Carcinoma

Article Cell Biology

POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1

Peng Zhang et al.

Summary: POLE2 plays a crucial role in glioblastoma and a novel mechanism involving AURKA-mediated stability of FOXM1 has been revealed.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Wen-jin Chen et al.

Summary: This study provides a comprehensive understanding of the heterogeneity and tumor biology of non-clear renal cell carcinomas (nccRCCs) using single-cell genomics. The study reveals the pivotal factors of immunosuppression in nccRCC tissues and their correlation with poor prognosis. Abnormal metabolic patterns were also found in both cancer cells and tumor-infiltrating stromal cells. The findings may contribute to the development of more effective therapies for nccRCC.

CELL DEATH & DISEASE (2022)

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Article Oncology

Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma

Yu-Lu Peng et al.

Summary: This study investigated the differences in tumor microenvironment (TME) and gene expression patterns between primary renal cell carcinoma (pRCC) and recurrent renal cell carcinoma (reRCC) at the single-cell level. The results showed that reRCC had reduced CD8(+) T cells and increased infiltration of cancer-associated fibroblasts (CAFs), which were significantly associated with a worse response to immunotherapy. In addition, the study identified that CAFs expressed LGALS1 (Gal1), which could induce apoptosis of CD8(+) T cells and suppress tumor growth. Knockdown of Gal1 in CAFs increased CD8(+) T cell infiltration and enhanced the efficacy of immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Oncology

Pegilodecakin as monotherapy or in combination with anti-PD-1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma: Final results of cohorts A, G, H and I of IVY Phase I study

Nizar M. Tannir et al.

Summary: IL-10 has anti-inflammatory and CD8+ T-cell-stimulating properties. Pegilodecakin shows promising activity in aRCC with manageable toxicity, and combination with pazopanib or anti-PD-1 inhibitors also demonstrates clinical activity. In the IVY study, pegilodecakin in combination with anti-PD-1 inhibitors shows potential clinical activity.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Immunology

Current Advance of Immune Evasion Mechanisms and Emerging Immunotherapies in Renal Cell Carcinoma

Yuli Jian et al.

Summary: Renal cell carcinoma is a highly heterogeneous cancer group, with immune evasion being a hot topic in current research. Immunotherapy is considered the best treatment option for patients with metastatic or advanced renal cell carcinoma, and combination immunotherapy shows promising prospects.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Pan-Cancer Molecular Characterization of m6A Regulators and Immunogenomic Perspective on the Tumor Microenvironment

Jie Zhu et al.

Summary: The study conducted comprehensive immuno-genomic analyses to reveal the molecular characterization of m(6)A regulators and immune-related genes across tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) heterogeneity. The findings showed the impact of crucial immune-related genes (IRGs) on TILs, TME characteristics, and clinical parameters, indicating the essential role of m(6)A regulators in phenotypic modifications of IRGs and affecting TME characteristics across various tumor types.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1

Chuanjie Zhang et al.

Summary: This study investigated the biological functions and mechanisms of DNA polymerase epsilon subunit 2 (POLE2) in renal cell carcinoma (RCC). Results showed that high POLE2 expression in RCC tissues was correlated with poor prognosis. Knockdown of POLE2 inhibited cell proliferation, migration and promoted apoptosis, and its regulation of STC1 suggested potential as a target for RCC therapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Oncology

Immunotherapies in Genitourinary Oncology: Where Are We Now? Where Are We Going?

Albert Jang et al.

Summary: Genitourinary malignancies encompass various cancers along the urinary and male reproductive tracts. Traditional immunotherapies have shown success in treating certain types of these cancers, while immune checkpoint inhibitors have emerged as a more precise method to enhance the immune system's ability to fight tumor cells. Despite promising data from clinical trials, there is still limited understanding of biomarkers that can predict response to these inhibitors, and the efficacy of ICIs varies across different tumor types in the genitourinary system.

CANCERS (2021)

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Review Oncology

Immune Checkpoint Inhibitors for Genitourinary Cancers: Treatment Indications, Investigational Approaches and Biomarkers

Brian W. Labadie et al.

Summary: Immune checkpoint inhibitors (ICI) have provided significant clinical benefit in genitourinary malignancies, especially in renal cell and urothelial carcinoma, but a large fraction of patients do not benefit from them. Identification of patient and tumor-derived factors associated with response has helped in understanding the mechanisms of response and resistance to ICI.

CANCERS (2021)

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Article Oncology

Construction, Validation, and Visualization of Two Web-Based Nomograms to Predict Overall and Cancer-Specific Survival in Patients with Gastric Cancer and Lung Metastases

Honghong Zheng et al.

Summary: Two nomograms were developed to predict overall survival (OS) and cancer-specific survival (CSS) in gastric cancer patients with lung metastasis (GCLM) using SEER database. The nomograms showed good predictive power, aiding in individualized treatment decisions for patients.

JOURNAL OF ONCOLOGY (2021)

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Article Oncology

LncRNA GAPLINC Promotes Renal Cell Cancer Tumorigenesis by Targeting the miR-135b-5p/CSF1 Axis

Siyuan Wang et al.

Summary: Our study identified that GAPLINC is significantly upregulated in RCC tissues and cell lines, and is associated with a poor prognosis in RCC patients. Knockdown of GAPLINC inhibited RCC growth in vitro and in vivo, while overexpression of GAPLINC had the opposite effect. Mechanistically, GAPLINC upregulates the oncogene CSF1 expression by acting as a sponge for miR-135b-5p.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, Research & Experimental

A pan-cancer analysis of the HER family gene and their association with prognosis, tumor microenvironment, and therapeutic targets

Xiaolong Yang et al.

Summary: The study comprehensively analyzed the expression of HER family genes in different cancers and their correlation with prognosis, tumor microenvironment, stemness characteristics, immune subtypes, and drug sensitivity. The findings revealed that HER family genes are upregulated in multiple cancers and closely associated with patient prognosis and immune features.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments

Yu Lei et al.

Summary: Systematic analysis revealed that overexpression of MCM in HCC is significantly associated with poor prognosis, with main function enriched in DNA replication. MCM is also linked to cancer pathways and drug sensitivity in HCC.

LIFE SCIENCES (2021)

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Article Oncology

Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer

Mingjun Zheng et al.

Summary: In this study, a prognostic 11-gene signature for advanced serous ovarian cancer was developed using lasso regression on tumor microenvironment-related genes. The established risk score showed improved accuracy in predicting the prognosis of ovarian cancer patients and the potential response to immunotherapy. This model was also found applicable to other cancer types, suggesting its broad usability in predicting biological responses to immunotherapy.

CANCERS (2021)

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Article Andrology

KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma

Shaohua Chen et al.

Summary: The study revealed a negative correlation between ImmuneScore and patient prognosis, indicating the importance of immune cells in the tumor microenvironment. Through intersection analysis, 118 immune-related genes were identified, with 6 critical genes used to build a prognostic model for KIRC. KCNN4 was identified as the most critical gene affecting KIRC prognosis, with further analysis showing its impact on the TME immune status and potential as a prognostic marker.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Review Oncology

Novel emerging biomarkers to immunotherapy in kidney cancer

Yasser Ged et al.

Summary: The treatment of metastatic renal cell carcinoma has significantly advanced with the advent of novel immune checkpoint inhibitors, but despite progress in biomarkers discovery, these have not been successfully integrated into clinical practice.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

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Article Medicine, Research & Experimental

High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma

Nu-Ri Jang et al.

Summary: The study found that high MCM6 expression in clear-cell renal cell carcinoma is significantly associated with tumor progression, metastasis, and shorter survival, suggesting it may serve as a promising biomarker for predicting patient outcomes.

IN VIVO (2021)

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Article Biochemistry & Molecular Biology

Mining TCGA database for screening and identification of hub genes in kidney renal clear cell carcinoma microenvironment

Song Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Cell Biology

Identification of an immune-related risk signature for predicting prognosis in clear cell renal cell carcinoma

Xiaoliang Hua et al.

AGING-US (2020)

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Review Oncology

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu Lei et al.

CANCER LETTERS (2020)

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Review Oncology

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Immunology

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression

Reem Saleh et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Urology & Nephrology

The immunology of renal cell carcinoma

C. Marcela Diaz-Montero et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Biochemistry & Molecular Biology

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Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

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Article Immunology

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

WeiYu Lin et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

Shuang Qin et al.

MOLECULAR CANCER (2019)

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Article Oncology

MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis

Marianne Samir Makboul Issac et al.

NEOPLASIA (2019)

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Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

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Review Medicine, Research & Experimental

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance

Catharina Conrad et al.

CLINICAL SCIENCE (2019)

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Review Oncology

First-line Treatment of Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis

Andrew W. Hahn et al.

EUROPEAN UROLOGY ONCOLOGY (2019)

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Article Cell Biology

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Christopher J. Ricketts et al.

CELL REPORTS (2018)

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Review Oncology

Biomarkers of immunotherapy in urothelial and renal cell carcinoma: PD-L1, tumor mutational burden, and beyond

Jason Zhu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Mechanistic overview of immune checkpoints to support the rational design of their combinations in cancer immunotherapy

A. Rotte et al.

ANNALS OF ONCOLOGY (2018)

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Article Medicine, General & Internal

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James J. Hsieh et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Biochemistry & Molecular Biology

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Stephane Chevrier et al.

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J. M. Michot et al.

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Etienne Becht et al.

GENOME BIOLOGY (2016)

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Michael S. Rooney et al.

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Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression

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Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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A Novel Prognostic Signature Associated With the Tumor Microenvironment in Kidney Renal Clear Cell Carcinoma

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