4.6 Article

Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Targeted sequencing to identify genetic alterations and prognostic markers in pediatric T-cell acute lymphoblastic leukemia

Ya-Hsuan Chang et al.

Summary: Targeted sequencing of 67 genes in 64 cases of childhood T-ALL revealed a variety of genetic mutations, with high frequencies observed in NOTCH1, FAT1, FAT3, and FBXW7. Mutations in certain genes were associated with better 5-year overall survival rates for patients.

SCIENTIFIC REPORTS (2021)

Article Oncology

Ruxolitinib as a Novel Therapeutic Option for Poor Prognosis T-LBL Pediatric Patients

Giulia Veltri et al.

Summary: JAK2 Y1007-1008 is identified as a potential prognostic marker and therapeutic target in pediatric patients with T-LBL, with hyperactivation of the JAK1/2-STAT6 pathway contributing to therapy resistance. Inhibition of the glucocorticoid receptor and the JAK1/2-STAT6 pathway by ruxolitinib has shown to reduce cell proliferation and increase apoptosis, suggesting a novel therapeutic approach for pediatric T-LBL patients.

CANCERS (2021)

Article Medicine, General & Internal

Prognostic Role of Minimal Disseminated Disease and NOTCH1/FBXW7 Mutational Status in Children with Lymphoblastic Lymphoma: The AIEOP Experience

Federica Lovisa et al.

Summary: The study validated the prognostic role of N/F mutational status in pediatric lymphoblastic lymphoma patients and found that the combination of MDD and N/F mutational status could identify patients with aggressive disease who might benefit from more intensive treatment, demonstrating the potential for more personalized therapy.

DIAGNOSTICS (2021)

Review Medicine, Research & Experimental

ERK/MAPK signalling pathway and tumorigenesis

Yan-Jun Guo et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Review Oncology

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Jin Zhou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Medical Laboratory Technology

AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of Pediatric acute lymphoblastic leukemia

Michael N. Dworzak et al.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2018)

Review Pathology

T-Lymphoblastic Leukemia/Lymphoma

M. James You et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2015)

Article Oncology

Long-term results of the AIEOP LNH-97 protocol for childhood lymphoblastic lymphoma

Marta Pillon et al.

PEDIATRIC BLOOD & CANCER (2015)

Article Oncology

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Isabelle Tancioni et al.

BREAST CANCER RESEARCH (2015)

Review Oncology

FAK in cancer: mechanistic findings and clinical applications

Florian J. Sulzmaier et al.

NATURE REVIEWS CANCER (2014)

Review Biochemistry & Molecular Biology

JAK/STAT signaling in hematological malignancies

W. Vainchenker et al.

ONCOGENE (2013)

Article Multidisciplinary Sciences

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Jinghui Zhang et al.

NATURE (2012)

Editorial Material Oncology

T-Lineage Lymphoblastic Lymphoma and Leukemia - a MASSive Problem

Charles G. Mullighan

CANCER CELL (2010)

Article Biology

Hierarchical testing of variable importance

Nicolai Meinshausen

BIOMETRIKA (2008)

Review Immunology

The JAK-STAT signaling pathway: Input and output intergration

Peter J. Murray

JOURNAL OF IMMUNOLOGY (2007)

Article Statistics & Probability

Testing against a high dimensional alternative

JJ Goeman et al.

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (2006)

Article Computer Science, Artificial Intelligence

Random forests

L Breiman

MACHINE LEARNING (2001)