4.6 Article

Inhibiting PI3K-AKT-mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells

Related references

Note: Only part of the references are listed.
Article Hematology

Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells

Helal Mohammed Mohammed Ahmed et al.

Summary: This study showed functional differences between AML MSCs and HD MSCs, with Notch signaling in AML MSCs enhancing AML cell proliferation, while dexamethasone or Notch inhibitors could disrupt the interaction between AML cells and AML MSCs, improving treatment outcomes in AML patients.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Article Oncology

Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway

Chao Liang et al.

Summary: The study demonstrates that the novel PI3K inhibitor pictilisib effectively inhibits osteosarcoma proliferation and enhances sensitivity to doxorubicin. Pictilisib also inhibits bone resorption both in vitro and in vivo by targeting the PI3K/AKT/GSK3 beta and NF-kappa B pathways, offering a potential treatment strategy for p-AKT-positive patients.

FRONTIERS IN ONCOLOGY (2021)

Article Immunology

The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape

Madelon M. E. de Jong et al.

Summary: The progression and therapy response of multiple myeloma is influenced by the bone marrow niche. A study identified inflammatory mesenchymal stromal cells that interact with tumor cells, indicating a potential role in disease persistence. Tracking bone marrow inflammation over time revealed a link to disease persistence despite successful antitumor therapy.

NATURE IMMUNOLOGY (2021)

Review Oncology

The microenvironment in myeloma

Oliver C. Lomas et al.

CURRENT OPINION IN ONCOLOGY (2020)

Review Oncology

PI3K/AKT/mTOR pathway in multiple myeloma: from basic biology to clinical promise

Vijay Ramakrishnan et al.

LEUKEMIA & LYMPHOMA (2018)

Article Multidisciplinary Sciences

Discovery and saturation analysis of cancer genes across 21 tumour types

Michael S. Lawrence et al.

NATURE (2014)

Article Multidisciplinary Sciences

Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells

Thibaud Andre et al.

PLOS ONE (2013)

Article Hematology

Management of Complications in Multiple Myeloma

Evangelos Terpos et al.

SEMINARS IN HEMATOLOGY (2009)

Article Immunology

Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells

Barbara Zdzisinska et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2008)

Article Oncology

Mesenchymal stem cell abnormalities in patients with multiple myeloma

Laurent Garderet et al.

LEUKEMIA & LYMPHOMA (2007)

Review Biotechnology & Applied Microbiology

Exploiting the PI3K/AKT pathway for cancer drug discovery

BT Hennessy et al.

NATURE REVIEWS DRUG DISCOVERY (2005)