Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.958756
Keywords
B cell; tumor; tumor immunity; cancer; immunotherapy; tumor microenvironment
Categories
Funding
- Education Reform Research of Central South University
- [2022jy147]
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B cells play a critical role in adaptive immune responses through antigen presentation and antibody production, but their function in tumor immunity varies among different tumor types. Antigen presentation of B cells is mainly anti-tumoral, while the role of antibody production is controversial. Immunosuppressive regulatory B cells negatively affect anti-tumor immunity through the secretion of anti-inflammatory cytokines.
B cells play a critical role in adaptive immune responses mainly due to antigen presentation and antibody production. Studies about the tumor-infiltrating immune cells so far demonstrated that the function of B cells in tumor immunity is quite different among various tumor types. The antigen presentation of B cells is mainly anti-tumoral, while the role of antibody production is controversial. Moreover, the immunosuppressive regulatory B cells are detrimental to anti-tumor immunity via the secretion of various anti-inflammatory cytokines. This review briefly summarizes the different roles of B cells classified by the primary function of B cells, antigen presentation, antibody production, and immunity regulation. Further, it discusses the potential therapeutic target of B cells in tumor immunity.
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