Potential utility of miRNAs for liquid biopsy in breast cancer

Article Biochemistry & Molecular Biology

Clinical role of MiRNA 29a and MiRNA 335 on breast cancer management: their relevance to MMP2 protein level

Elham Ali Ahmed et al.

Summary: Expression levels of miR-29a and miR-335 have significant potential as biomarkers in breast cancer diagnosis.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Oncology

Development and validation of a circulating microRNA panel for the early detection of breast cancer

Ruiyang Zou et al.

Summary: This study conducted the largest comprehensive multi-center research to date and identified 30 dysregulated miRNAs associated with breast cancer. An optimized eight-miRNA panel was successfully validated in diverse ethnic groups and showed consistent performance. The panel has the potential to be used for breast cancer screening in conjunction with mammography.

BRITISH JOURNAL OF CANCER (2022)

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Review Genetics & Heredity

Clinical utility of liquid biopsy in breast cancer: A systematic review

Galo Duque et al.

Summary: This systematic review focuses on the clinical utility of liquid biopsy in patients with breast cancer, indicating its importance for diagnosis, treatment and follow-up in this context. The clinical applications of liquid biopsy in breast cancer are found to be clinically significant, although there is heterogeneity in the publications.

CLINICAL GENETICS (2022)

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Article Obstetrics & Gynecology

Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure

Carolina von Grothusen et al.

Summary: This study compares the abundance of miRNAs in uterine fluid between healthy fertile women and women with recurrent implantation failure (RIF). The results show that the composition of miRNAs in RIF uterine fluid is different from that of healthy fertile women, and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation. These findings shed light on the molecular mechanisms behind RIF and may have implications for future biomarker and clinical treatment studies.

HUMAN REPRODUCTION (2022)

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Article Oncology

Circulating microRNA-103a-3p could be a diagnostic and prognostic biomarker for breast cancer

Hui Liu et al.

Summary: The expression level of miR-103a-3p in breast cancer is associated with disease severity and patient survival outcomes. Circulating serum miR-103a-3p could potentially serve as a non-invasive diagnostic and prognostic biomarker for breast cancer.

ONCOLOGY LETTERS (2022)

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Review Oncology

Liquid Biopsy in Metastatic Breast Cancer: Current Role of Circulating Tumor Cells and Circulating Tumor DNA

Maggie Banys-Paluchowski et al.

Summary: Blood-based diagnostics, including the detection of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), have shown potential in improving prognosis assessment and therapy choices for metastatic breast cancer (MBC). High CTC counts have been confirmed as an independent prognostic factor, and interventions guided by liquid biopsy have shown promising results. However, the prognostic value of ctDNA and the optimal therapeutic options for patients with persistently high CTC numbers still require further investigation.

ONCOLOGY RESEARCH AND TREATMENT (2022)

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Review Oncology

Nipple Aspirate Fluid at a Glance

Susana I. S. Patuleia et al.

Summary: Nipple aspirate fluid (NAF) is a promising source of biomarkers for early breast cancer detection. It can be non-invasively collected via the nipple and used as a tool for breast cancer detection or as a supporting diagnostic tool for breast imaging. Ongoing clinical studies will provide more insights into the clinical potential of NAF.

CANCERS (2022)

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Review Oncology

Role of ctDNA in Breast Cancer

Marta Sant et al.

Summary: Circulating tumor DNA (ctDNA) plays an important role in breast cancer research and clinical practice, allowing for screening, diagnosis, treatment selection, and prognosis assessment. Analysis of ctDNA provides a more accurate understanding of the heterogeneity of breast cancer, enabling monitoring of disease progression and resistance mutations. With the application of new bioinformatics tools, the use of ctDNA in breast cancer will become more frequent, enhancing our knowledge of tumor biology.

CANCERS (2022)

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Review Oncology

Unveiling the Potential of Liquid Biopsy in HER2-Positive Breast Cancer Management

Ana Godoy-Ortiz et al.

Summary: Liquid biopsy is a validated and minimally invasive tool to obtain circulating tumor components, with clinical validity demonstrated in both early and metastatic HER2-positive breast cancer (BC).

CANCERS (2022)

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Review Oncology

Blood Circulating Non-Coding RNAs for the Clinical Management of Triple-Negative Breast Cancer

Tomasz Powrozek et al.

Summary: This paper reviews the latest research on the use of blood circulating non-coding RNAs (ncRNAs) for the management of triple negative breast cancer (TNBC). The review is supplemented by bioinformatic analysis to better understand the role of ncRNAs in the development of TNBC phenotype.

CANCERS (2022)

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Review Oncology

Circulating Biomarkers in Breast Cancer

Katelyn N. Seale et al.

Summary: Breast cancer management has made significant progress, but it remains a major global health issue. Circulating biomarkers can provide important information on disease progression and treatment response, aiding in treatment decisions.

CLINICAL BREAST CANCER (2022)

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Article Obstetrics & Gynecology

Circulating miR-200 family as predictive markers during systemic therapy of metastatic breast cancer

Chiara Fischer et al.

Summary: This study investigated the expression of miRNAs in metastatic breast cancer patients and its predictive value for early and late relapse as well as response to systemic therapy.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Oncology

Total circulating microRNA level as an independent prognostic marker for risk stratification in breast cancer

Aoife Ward Gahlawat et al.

Summary: This study suggests that total cf-miRNA levels in the blood can be used as an independent prognostic marker for breast cancer, correlating with unfavorable clinical features and cancer relapse.

BRITISH JOURNAL OF CANCER (2022)

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Article Biochemistry & Molecular Biology

The functional significance and cross-talk of non-coding RNAs in triple negative and quadruple negative breast cancer

Utpalendu Paul et al.

Summary: Breast cancer is one of the leading causes of cancer-related deaths worldwide, with triple-negative breast cancer (TNBC) being the most malignant subtype. Non-coding RNAs, including miRNAs, lncRNAs, and circRNAs, play a significant role in tumorigenesis by regulating gene expression. Recent research suggests that non-coding RNAs could serve as biomarkers for the diagnosis of TNBC.

MOLECULAR BIOLOGY REPORTS (2022)

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Article Medicine, General & Internal

Use of Liquid Biopsy to Detect PIK3CA Mutation in Metastatic Breast Cancer

Maki Nakai et al.

Summary: Liquid biopsy was used to detect PIK3CA mutations in patients with breast cancer. The study found that PIK3CA mutations can be detected even in patients with no mutations in their primary tumors. Combining tissue and liquid biopsies can provide clinically useful information for patients with breast cancer.

JOURNAL OF NIPPON MEDICAL SCHOOL (2022)

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Article Immunology

Tear miRNAs Identified in a Murine Model of Sjogren's Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism

Shruti Singh Kakan et al.

Summary: Differentially expressed miRNAs were identified in tears of male NOD mice, with some preliminary validation in SS patients, including some never previously linked to SS. These miRNAs may have potential utility as indicators of ocular symptoms of SS, and evaluation of the pathways influenced by these dysregulated miRNAs may also provide further insights into SS pathogenesis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors

Jouni Kujala et al.

Summary: The study evaluated the concordance between cfDNA and tumor DNA genetic profiles, showing that liquid biopsy can reflect the heterogeneity and clonal evolution of BC, potentially identifying driver variants and therapeutic targets that may be missed in tumor DNA sequencing. Liquid biopsy may aid in the early detection of metastatic BC and support clinical decision-making, despite observed discordance between the two sources of DNA.

CANCERS (2022)

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Review Oncology

Current and Developing Liquid Biopsy Techniques for Breast Cancer

Hsing-Ju Wu et al.

Summary: This article summarizes the recent discoveries on liquid biopsy and detection techniques. Breast cancer is the most common cancer and leading cause of death worldwide, highlighting the importance of early diagnosis. Liquid biopsy, as a less invasive diagnostic tool, is gaining more attention.

CANCERS (2022)

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Review Oncology

Immunotherapy in Breast Cancer and the Potential Role of Liquid Biopsy

Mark Jesus M. Magbanua et al.

Summary: Liquid biopsy biomarkers, such as CTCs and ctDNA, are noninvasive diagnostics that can complement current predictive and prognostic tools in breast cancer treatment. They have been applied in evaluating immune therapy response and outcomes, with emerging technologies further advancing their applications.

FRONTIERS IN ONCOLOGY (2022)

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Article Biophysics

Simultaneous dual-targeted monitoring of breast cancer circulating miRNA via surface-enhanced Raman spectroscopy

Jinyoung Kim et al.

Summary: Breast cancer is a common global cancer, and early detection is crucial for improving the 5-year survival rate. In this study, the combination of seed-mediated grown silver nanopillars and surface-enhanced Raman spectroscopy was used for rapid and sensitive detection of circulating miRNA in breast cancer.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Oncology

Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer

Valentina K. Todorova et al.

Summary: This study investigated the potential of circulating exosomal microRNAs to predict pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NACT). Several microRNAs were found to be associated with pCR and correlated with survival, subtype, and metastasis in breast cancer.

CURRENT ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Serum MiRNA-27a as potential diagnostic nucleic marker for breast cancer

Menha Swellarn et al.

Summary: miR 27a shows potential as a diagnostic marker for breast cancer, with its expression being more effective than tumor markers, especially in early detection of high-risk breast cancer patients.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Review Medical Laboratory Technology

Liquid Biopsy in Breast Cancer

Timothy Kwang Yong Tay et al.

Summary: Liquid biopsies have shown promising results in breast cancer, particularly in monitoring treatment response and predicting disease progression or relapse. With further research and advancements in technology, liquid biopsies may have a greater role in the breast cancer clinic in the future.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

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Article Multidisciplinary Sciences

Preliminary evaluation of miR-1307-3p in human serum for detection of 13 types of solid cancer using microRNA chip

Koji Hashimoto et al.

Summary: Early detection and treatment are crucial for increasing the survival rates of various cancers. Circulating microRNA is reported as potential biomarkers for cancer, and miR-1307-3p in serum has shown potential relevance for the development of new diagnostic tools for cancer patients.

HELIYON (2021)

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Article Multidisciplinary Sciences

Therapeutic advances of miRNAs: A preclinical and clinical update

Chiranjib Chakraborty et al.

Summary: This review discusses the current status of miRNAs as biopharmaceuticals, the clinical trials of miRNA therapeutics, and recent advancements in the absorption, distribution, metabolism, excretion, and delivery system of miRNAs.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Cell Biology

Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers

Dongdong Liu et al.

Aging-US (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Multi-miRNA panel of tumor-derived extracellular vesicles as promising diagnostic biomarkers of early-stage breast cancer

Min Woo Kim et al.

Summary: Extracellular vesicles, particularly tumor-derived ones, have potential as biomarkers for disease monitoring, such as early cancer detection. A study using a novel microfluidic device isolated cancerous EV expressing breast cancer-derived markers and validated high miRNA expression levels in early-stage breast cancer patients. The combination of specific miRNA signatures from EV showed high sensitivities in different subtypes of early-stage breast cancer, indicating the potential for early diagnosis using liquid biopsy.

CANCER SCIENCE (2021)

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Article Oncology

Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer

Xuemin Liu et al.

Summary: The study demonstrated that miR-155 may serve as a promising diagnostic biomarker for breast cancer due to its high diagnostic accuracy and important role in the pathogenesis of the disease. Well-designed cohort studies and biological experiments are needed to confirm its diagnostic value before routine clinical application.

BREAST CANCER (2021)

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Article Biotechnology & Applied Microbiology

Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer

Siqi Bao et al.

Summary: The study identified a three miRNA signature in extracellular vesicles of breast cancer patients, which was significantly associated with poor prognosis in all tested cohorts and remained as an independent prognostic factor in multivariate analyses. When integrated with clinical characteristics, the composite miRNA-clinical prognostic indicator improved prognostic performance. The miGISig showed high accuracy in differentiating breast cancer from healthy controls in multiple cohorts.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Oncology

Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis

Andrea York Tiang Teo et al.

Summary: MiRNAs play important regulatory roles in breast cancer metastasis, with oncogenic miRNAs identified to potentiate key processes such as angiogenesis, epithelial-mesenchymal transition, the Warburg effect, and the tumour microenvironment. MiRNA-based therapies show promise in controlling breast cancer progression and metastasis, but challenges including toxicity and immunogenicity must be addressed before clinical trials.

CANCERS (2021)

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Review Cell Biology

Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice

Paul Hofman

Summary: The review discusses the mechanisms of resistance to therapeutics targeting genomic alterations in ALK as well as the advantages and limitations of liquid biopsies for their identification.

CELLS (2021)

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Article Biotechnology & Applied Microbiology

Circulating status of microRNAs 660-5p and 210-3p in breast cancer patients

Zahra Nashtahosseini et al.

Summary: The study investigated the expression levels of serum miR-660-5p and miR-210-3p in breast cancer patients compared to healthy controls. The results showed significant up-regulation of these microRNAs in breast cancer patients, especially in the early stages, indicating their potential as biomarkers for breast cancer detection with reasonable sensitivity and specificity. Further large-scale studies are needed to confirm these preliminary findings.

JOURNAL OF GENE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages

Hanieh Sadeghi et al.

Summary: This study aimed to assess the relationship between blood-based miRNAs and demographic characteristics of breast cancer patients, finding a potential multi-marker panel for early detection of breast cancer with acceptable sensitivity, specificity, and accuracy. The panel also showed promise in distinguishing benign breast diseases from breast cancer patients.

RNA BIOLOGY (2021)

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Article Ophthalmology

Tear miRNA expression analysis reveals miR-203 as a potential regulator of corneal epithelial cells

Ayumi Nakagawa et al.

Summary: The study identified miR-203 as highly expressed in tears, and inhibition of miR-203 increased the viability of corneal epithelial cells, suggesting its role in regulating corneal epithelial cell homeostasis.

BMC OPHTHALMOLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanoporous Anodic Alumina-Based Sensor for miR-99a-5p Detection as an Effective Early Breast Cancer Diagnostic Tool

Iris Garrido-Cano et al.

Summary: The NAA-based biosensor successfully detected plasma miR-99a-5p with high sensitivity and selectivity, distinguishing healthy controls from breast cancer patients with high efficiency, showing promising application prospects.

ACS SENSORS (2021)

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Article Oncology

Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer

A. Adam-Artigues et al.

Summary: miR-30b-5p expression in breast cancer tissue and plasma differs significantly from healthy samples, with higher levels in plasma of BC patients. This miRNA demonstrates good potential for early diagnosis of breast cancer.

ESMO OPEN (2021)

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Article Biochemistry & Molecular Biology

MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development

Ines Figueira et al.

Summary: The study on biomarkers of triple negative breast cancer brain metastases (BCBM) reveals miRNAs and EVs in the circulation as potential indicators of BCBM formation. Results suggest that circulating miRNAs and EVs of blood-brain barrier origin can be utilized as markers for early and advanced stages of BCBM detection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Dimitri Papukashvili et al.

Summary: Androgenetic alopecia (AGA) is a challenging issue that requires the development of new treatment methods. The Wnt/β-catenin signaling pathway is crucial for hair growth and can be targeted for AGA therapy.

CELLS (2021)

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Review Biochemistry & Molecular Biology

MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

Bashdar Mahmud Hussen et al.

Summary: This article summarizes the important role of miRNA in breast tumor angiogenesis development, emphasizing the key roles of different miRNAs in disease processes, especially their overexpression in various diseases related to angiogenesis. More research is needed to reveal the relationship between miRNA expression and angiogenic pathways, immune response-related genes, and to provide more evidence for finding new therapeutic targets.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Multidisciplinary Sciences

Small extracellular vesicle-encapsulated miR-181b-5p, miR-222-3p and let-7a-5p: Next generation plasma biopsy-based diagnostic biomarkers for inflammatory breast cancer

Sarah Hamdy Ahmed et al.

Summary: Inflammatory breast cancer is a rare but aggressive form of breast cancer that can be diagnosed through miRNAs in small extracellular vesicles in the blood, with certain miRNAs found to be associated with the cancer. Analyzing these miRNAs can serve as promising diagnostic biomarkers for IBC.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer

Mehreen Aftab et al.

Summary: The study found that miRNAs in urine can serve as reliable non-invasive biomarkers for cervical cancer, showing good sensitivity and specificity. A combination of miR-145-5p, miR-218-5p, and miR-34a-5p in urine performed well in distinguishing precancer and cancer patients, with strong correlations with serum and tumor tissues.

SCIENTIFIC REPORTS (2021)

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Article Genetics & Heredity

Clinical Identification of Dysregulated Circulating microRNAs and Their Implication in Drug Response in Triple Negative Breast Cancer (TNBC) by Target Gene Network and Meta-Analysis

Amal Qattan et al.

Summary: The study identified circulating miRNAs that are significantly differentially expressed in TNBC patients and regulate multiple molecular pathways involved in drug resistance. Upregulated miR-93, miR-210, miR-19a, and miR-19b were associated with poor overall survival outcomes in TNBC patients. Integrated analysis of multidimensional data revealed miRNA-regulated mechanisms of drug resistance and potential targets for combination with chemotherapy in TNBC.

GENES (2021)

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Review Oncology

Glioblastoma and MiRNAs

Swalih P. Ahmed et al.

Summary: Glioblastoma (GB) is a lethal brain tumor with limited treatment options and poor prognosis. The use of miRNA in GB diagnosis and treatment is being explored, but further research is needed to understand its relationship with glioblastoma.

CANCERS (2021)

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Article Oncology

Development of a microRNA Panel for Classification of Abnormal Mammograms for Breast Cancer

Ruiyang Zou et al.

Summary: Breast cancer screening using mammography often leads to false positive results, prompting unnecessary investigations. This study identified and validated a six-miRNA panel that can differentiate between malignant and benign breast lesions, showing potential for use alongside mammography. Results also revealed an increase in biomarker panel scores with tumor size, stage, and lymph node involvement.

CANCERS (2021)

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Article Medical Laboratory Technology

Potential value of circulatory microRNA10b gene expression and its target E-cadherin as a prognostic and metastatic prediction marker for breast cancer

Fatma Ibrahim Dwedar et al.

Summary: The study found that circulating levels of miR-10b and serum sE-cadherin were significantly elevated in breast cancer patients compared to controls. Serum miR-10b showed a progressive upregulation in advanced stages, with higher levels in metastatic BC. The combined use of serum miR-10b and sE-cadherin exhibited high sensitivity and specificity for detecting BC metastasis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Oncology

Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer

Xin Wang et al.

Summary: Plasma exosomal miR-363-5p plays a tumor suppressor role in breast cancer and has the potential for noninvasive LN staging and prognosis prediction.

MOLECULAR ONCOLOGY (2021)

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Article Pathology

A two-miRNA signature of upregulated miR-185-5p and miR-362-5p as a blood biomarker for breast cancer

Kai Zhang et al.

Summary: The study identified six upregulated miRNAs and a two-miRNA panel in the blood as potential biomarkers for the diagnosis and prognosis of breast cancer. The two-miRNA panel showed a better diagnostic performance than individual miRNAs, with high sensitivity and specificity. The high expression of these miRNAs was also associated with poor prognosis in breast cancer.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Multidisciplinary Sciences

Differences in plasma microRNA content impair microRNA-based signature for breast cancer diagnosis in cohorts recruited from heterogeneous environmental sites

Jeanne P. Uyisenga et al.

Summary: The study evaluated the diagnostic performance of circulating microRNAs in breast cancer in populations from Belgium and Rwanda, finding that while there is no universal circulating signature, specific signatures can be identified for different populations.

SCIENTIFIC REPORTS (2021)

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Review Oncology

The Emerging Role of Circulating Tumor DNA in the Management of Breast Cancer

Mira Shoukry et al.

Summary: As breast cancer diagnoses continue to increase globally, exploring the role of liquid biopsies and circulating tumor DNA (ctDNA) in diagnosis and surveillance becomes increasingly important. CtDNA is emerging as a potential biomarker for breast cancer, offering personalized and effective treatment approaches.

CANCERS (2021)

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Review Oncology

Urine as a Source of Liquid Biopsy for Cancer

Masanori Oshi et al.

Summary: Liquid biopsy, including urine analysis, has become a popular and less invasive method for detecting circulating tumor cells and nucleic acids in cancer patients. It allows for longitudinal repeat sampling and can provide real-time information on tumor evolution, making it a powerful tool for diagnosis and treatment monitoring in both urological and non-urological cancers. Advances in extraction methods of urinary substances have shown close relationships with carcinogenesis, metastasis, and therapeutic response in various types of cancers.

CANCERS (2021)

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Article Oncology

Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer

Anna Adam-Artigues et al.

Summary: The study developed and validated a plasma microRNA signature as a non-invasive biomarker for early-stage breast cancer diagnosis. Results confirmed the value of the signature based on miR-30b and miR-99a levels in plasma samples, demonstrating its potential for very early detection. The proposed microRNA signature presents a high value as a fast, cost-effective, and non-invasive biomarker for early-stage breast cancer detection.

CANCERS (2021)

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Review Oncology

Translational Utility of Liquid Biopsies in Thyroid Cancer Management

Ayanthi A. Wijewardene et al.

Summary: Liquid biopsies are a novel technique that assess for circulating tumor cells (CTC), circulating tumor DNA (ctDNA), and microRNA in peripheral blood samples of cancer patients. The diagnostic role of liquid biopsy in oncology has expanded in recent years, especially in lung, colorectal, and breast cancer. In thyroid cancer, liquid biopsy's role in diagnosis or prognosis is transitioning from the lab to clinical practice.

CANCERS (2021)

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Review Oncology

Cancer Epigenetic Biomarkers in Liquid Biopsy for High Incidence Malignancies

Cora Palanca-Ballester et al.

Summary: In addition to genetic changes, cancer is also characterized by epigenetic alterations that can be used for diagnosis, prognosis, and predicting drug response. These changes can be detected in early stages of cancer and through liquid biopsies, offering valuable information for personalized treatment. Validation and standardization of epigenetic biomarkers are needed for their successful transfer from research to clinical practice.

CANCERS (2021)

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Article Cell Biology

A Novel TCGA-Validated, MiRNA-Based Signature for Prediction of Breast Cancer Prognosis and Survival

Baoxing Tian et al.

Summary: A novel model based on miRNA-seq and clinical data was constructed, revealing the significant association of a five-miRNA signature with disease-specific survival of BC patients. The signature efficiently distinguished high- and low-risk patients and exhibited high sensitivity and specificity in predicting BC patient prognosis. This study presents a reliable prognostic tool to predict DSS and provides theoretical significance for individualized clinical decisions for BC patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Medicine, General & Internal

Breast Cancer Heterogeneity

Caterina Fumagalli et al.

Summary: Breast tumor heterogeneity presents a major challenge in the clinical management of breast cancer patients, with each breast cancer potentially having different prognosis and benefiting from specific therapy. The dynamic nature of breast cancer, evolving during tumor progression and metastatization, poses challenges for personalized medicine approaches. Evaluation of biopsies from metastatic sites is crucial for determining the most effective therapeutic strategy for recurrent disease, with radiogenomics and liquid biopsy being valuable non-invasive tools for assessing breast cancer heterogeneity.

DIAGNOSTICS (2021)

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Review Biochemistry & Molecular Biology

Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR

Irina Palacin-Aliana et al.

Summary: Cancer remains a major public health challenge worldwide, and molecular pathology profiling is fundamental for tumor diagnosis and therapeutic decisions. Liquid biopsies show potential as a tool for detecting cancer-specific biomarkers, providing information about tumor dynamics.

BIOMEDICINES (2021)

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Article Biotechnology & Applied Microbiology

Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes

Noha M. Bakr et al.

Summary: The study observed upregulation of miRNA-373 and its target genes in breast cancer patients, suggesting their potential as biomarkers for diagnosis and prognosis. The expression levels of these miRNAs and genes showed significant associations with clinical features.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

Jing Xun et al.

Summary: This study demonstrates that miR-138-5p delivered from breast cancer cells to tumor-associated macrophages via exosomes can downregulate KDM6B expression, inhibit M1 polarization, and stimulate M2 polarization, ultimately promoting tumor metastasis. Additionally, exosomal miR-138-5p levels positively correlate with the progression of breast cancer, suggesting it as a potential prognostic marker and therapeutic target.

THERANOSTICS (2021)

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Article Medicine, General & Internal

Early detection breast cancer: role of circulating plasma miRNA-21 expression as a potential screening biomarker

Muhammad Noor Diansyah et al.

Summary: The study suggests that circulating plasma miRNA-21 may serve as an early detection biomarker for breast cancer in Indonesian population, with potential predictive value for breast cancer risk.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

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Article Oncology

Multiple microRNAs as biomarkers for early breast cancer diagnosis

Ji Young Jang et al.

Summary: MicroRNAs present in plasma can be used as potential biomarkers for early detection of breast cancer. Combinations of multiple miRNAs show higher accuracy in detecting breast cancer compared to single biomarkers. These miRNA biomarkers are expected to overcome limitations of mammography when used as an auxiliary diagnosis.

MOLECULAR AND CLINICAL ONCOLOGY (2021)

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Article Oncology

Relative and Absolute Expression Analysis of MicroRNAs Associated with Luminal A Breast Cancer- A Comparison

Vahid Arabkari et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

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Article Genetics & Heredity

Circulating miR-532-502 cluster derived from chromosome X as biomarkers for diagnosis of breast cancer

Xuan Zou et al.

GENE (2020)

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Article Cell Biology

miR-188-5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer

Mei Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Bioinformatic analysis of peripheral blood miRNA of breast cancer patients in relation with anthracycline cardiotoxicity

Yadi Wang et al.

BMC CARDIOVASCULAR DISORDERS (2020)

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Review Biochemistry & Molecular Biology

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

Youn-Sang Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Salivary MicroRNA for Diagnosis of Cancer and Systemic Diseases: A Systematic Review

Giacomo Setti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Genetics & Heredity

Emergence of Circulating MicroRNAs in Breast Cancer as Diagnostic and Therapeutic Efficacy Biomarkers

Vaishali Aggarwal et al.

MOLECULAR DIAGNOSIS & THERAPY (2020)

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Article Oncology

Downregulation of circulating miR 802-5p and miR 194-5p and upregulation of brain MEF2C along breast cancer brain metastasization

Marta Sereno et al.

MOLECULAR ONCOLOGY (2020)

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Article Oncology

Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles

Yumiko Koi et al.

CANCER SCIENCE (2020)

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Article Genetics & Heredity

MiR-199b-5p Suppresses Tumor Angiogenesis Mediated by Vascular Endothelial Cells in Breast Cancer by Targeting ALK1

Xiao Lin et al.

FRONTIERS IN GENETICS (2020)

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Article Multidisciplinary Sciences

Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma

Rushdi S. Fadhil et al.

PLOS ONE (2020)

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Review Medical Laboratory Technology

Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers

Patricia Midori Murobushi Ozawa et al.

TRANSLATIONAL RESEARCH (2020)

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Article Medicine, Research & Experimental

MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway

Shaoying Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Biotechnology & Applied Microbiology

Changes of miRNA Expression Profiles from Cervical-Vaginal Fluid-Derived Exosomes in Response to HPV16 Infection

Ying Wu et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

Potential of Using Cell-Free DNA and miRNA in Breast Milk to Screen Early Breast Cancer

Qinghe Song et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Physiology

MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise

Sira Karvinen et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway

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Pathway Analysis of Selected Circulating miRNAs in Plasma of Breast Cancer Patients: A Preliminary Study

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Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer

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Plasma miRNA Levels for Predicting Therapeutic Response to Neoadjuvant Treatment in HER2-positive Breast Cancer: Results from the NeoALTTO Trial

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Branched rolling circle amplification method for measuring serum circulating microRNA levels for early breast cancer detection

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