Epigenetic Memories in Hematopoietic Stem and Progenitor Cells

The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are responses to transient stimulation and result in better responses to secondary challenges. Not only innate system cells, such as macrophages, monocytes, and natural killer cells, but also bone marrow hematopoietic stem cells (HSCs) have been found to gain memories upon transient stimulation, leading to the enhancement of responses to secondary challenges. Various stimuli, including microbial infection, can induce the epigenetic reprogramming of innate immune cells and HSCs, which can result in an augmented response to secondary stimulation. In this review, we introduce novel NGS technologies and their application to unraveling epigenetic memories that are key in trained immunity and summarize the recent findings in trained immunity. We also discuss our most recent finding regarding epigenetic memory in aged HSCs, which may be associated with the exposure of HSCs to aging-related stresses.

Automated summary

The recent development of next-generation sequencing technologies has led to significant advancements in understanding biological processes, particularly in the field of trained immunity. Epigenetic memories play a crucial role in enhancing immune responses to secondary challenges, not only in innate immune cells but also in hematopoietic stem cells. In response to various stimuli, including microbial infections, these memories can be induced, leading to improved immune responses.