4.6 Article

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

Related references

Note: Only part of the references are listed.
Article Cell Biology

Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease

Anna Luna Molgaard Tams et al.

Summary: Visual changes are among the earliest symptoms observed in patients with Alzheimer's disease (AD). Research has shown that there are pathophysiological processes occurring in the retina of AD patients and animal models, including amyloid-beta plaque formation, vascular changes, neuroinflammation, and loss of retinal ganglion cells. Studies on the 5xFAD mouse model have revealed that there may be metabolic alterations in the retina of AD, which could impact the activity and survival of retinal ganglion cells.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

Article Physiology

L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA1

Marvin Lambertus et al.

Summary: Our study found that HCA(1) activation enhances neurogenesis in the ventricular-subventricular zone, but has minimal impact on neurogenesis in the subgranular zone. This indicates a potentially important role of HCA(1) in the regulation of neurogenesis.

ACTA PHYSIOLOGICA (2021)

Article Neurosciences

Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice

Adam J. Lundquist et al.

Summary: The study found that l-Lactate can promote the expression of neurotrophic genes in astrocytes and increase the morphological complexity of astrocytes in the striatum, suggesting a potential link between peripheral l-Lactate production, intensive exercise, and neuroplasticity in specific brain regions through astrocytic function. However, the effects of peripheral l-Lactate on synaptogenesis or motor behavior were not demonstrated, possibly due to insufficient levels and delivery of l-Lactate through regional cerebral blood flow in the striatum.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Article Multidisciplinary Sciences

L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro

Alexandra Poetzsch et al.

Summary: The study showed that L-lactate has a pro-proliferative effect on neural precursor cells, which is dependent on the active lactate transport by monocarboxylate transporters and is not linked to amplified mitochondrial respiration. L-lactate redirected glucose metabolism to the pentose phosphate pathway, as indicated by increased glucose-6-phosphate dehydrogenase activity and decreased glycolysis.

ISCIENCE (2021)

Article Cell Biology

Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

Samuel Laroche et al.

Summary: The study demonstrated that L-lactate and its receptor GPR81 play a crucial role in the growth of retinal ganglion cell axons by promoting growth cone morphology and axon growth. This effect is mediated by protein kinases A and C and has a significant impact on the development of the visual nervous system in mice.

CELLS (2021)

Review Medicine, General & Internal

Glaucoma Clinical Research: Trends in Treatment Strategies and Drug Development

Line Storgaard et al.

Summary: The number of clinical trials in glaucoma research has significantly increased in recent years, covering main treatment strategies of lowering intraocular pressure, neuroprotection, and vascular treatments. However, clinical trials in neuroprotection and vascular modalities are still limited. Stricter phenotyping of patients may improve success rates.

FRONTIERS IN MEDICINE (2021)

Review Neurosciences

Lactate: More Than Merely a Metabolic Waste Product in the Inner Retina

Rupali Vohra et al.

MOLECULAR NEUROBIOLOGY (2020)

Article Behavioral Sciences

Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling

Claire J. Scavuzzo et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2020)

Review Ophthalmology

Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment

Barbara Cvenkel et al.

JOURNAL OF OPHTHALMOLOGY (2020)

Article Biochemistry & Molecular Biology

Lactate-Mediated Protection of Retinal Ganglion Cells

Rupali Vohra et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

Article Neurosciences

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits

Haissa de Castro Abrantes et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Neurosciences

Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication

Carlos-Alberto Goncalves et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Ophthalmology

Potential metabolic markers in glaucoma and their regulation in response to hypoxia

Rupali Vohra et al.

ACTA OPHTHALMOLOGICA (2019)

Article Ophthalmology

Dual Properties of Lactate in Muller Cells: The Effect of GPR81 Activation

Rupali Vohra et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Metabolomics and Isotope Tracing

Cholsoon Jang et al.

Article Neurosciences

Essential Roles of Lactate in Muller Cell Survival and Function

Rupali Vohra et al.

MOLECULAR NEUROBIOLOGY (2018)

Editorial Material Cell Biology

Neuroprotection of the inner retina: Muller cells and lactate

Rupali Vohra et al.

NEURAL REGENERATION RESEARCH (2018)

Article Multidisciplinary Sciences

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Cecilie Morland et al.

NATURE COMMUNICATIONS (2017)

Article Obstetrics & Gynecology

Lactate produced during labor modulates uterine inflammation via GPR81 ( HCA1)

Ankush Madaan et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2017)

Article Biochemistry & Molecular Biology

Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease

Miriam Kolko et al.

NEUROCHEMICAL RESEARCH (2016)

Review Ophthalmology

Evaluating retinal ganglion cell loss and dysfunction

Ben Mead et al.

EXPERIMENTAL EYE RESEARCH (2016)

Review Neurosciences

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

James B. Hurley et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2015)

Article Oncology

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

Christina L. Roland et al.

CANCER RESEARCH (2014)

Article Multidisciplinary Sciences

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina

Ken J. Lindsay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Ophthalmology

The Role of Inflammation in the Pathogenesis of Glaucoma

Rupali Vohra et al.

SURVEY OF OPHTHALMOLOGY (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Review Neurosciences

The Neuronal Organization of the Retina

Richard H. Masland

NEURON (2012)

Article Pharmacology & Pharmacy

3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes

Changlu Liu et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Biochemistry & Molecular Biology

Regulation of glutamate metabolism by hydrocortisone and branched chain keto acids in cultured rat retinal Muller cells (TR-MUL)

Mohammad Shamsul Ola et al.

NEUROCHEMISTRY INTERNATIONAL (2011)

Article Ophthalmology

Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss

Ileana Soto et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Surgery

A Different View of Lactate in Trauma Patients: Protecting the Injured Brain

Elizabeth L. Cureton et al.

JOURNAL OF SURGICAL RESEARCH (2010)

Article Cell Biology

Inhibition of glycolysis in the retina by oxidative stress: prevention by pyruvate

K. R. Hegde et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

Changlu Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

Tian-Quan Cai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Review Ophthalmology

Mitochondrial dysfunction as a cause of optic neuropathies

V Carelli et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2004)