Journal
CELLS
Volume 11, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/cells11142251
Keywords
FGF-21; pregnancy; preeclampsia; menstrual cycle
Categories
Funding
- Universidad Nacional de Colombia (Direccion de investigaciones de Sede Bogota)
- School of Medicine and Ministerio de Ciencia, Tecnologia e Innovacion [202010012913-2019-INV]
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This study investigated the serum FGF-21 levels in healthy and mild preeclamptic pregnant women at different stages of pregnancy. The results showed that FGF-21 levels were highest in the third trimester of healthy pregnancy and higher throughout the entire pregnancy in preeclamptic women. FGF-21 may play a critical role in protecting against the negative effects of high concentrations of NEFA and hypertensive disorder, as well as in reproductive function during the menstrual cycle in healthy women.
(1) Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
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