Related references
Note: Only part of the references are listed.New insights on familial colorectal cancer type X syndrome
Felipe Antonio de Oliveira Garcia et al.
SCIENTIFIC REPORTS (2022)
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
Jianhang Yin et al.
NATURE COMMUNICATIONS (2022)
Identification and validation of prognosis-associated DNA repair gene signatures in colorectal cancer
Dingli Song et al.
SCIENTIFIC REPORTS (2022)
Werner Syndrome Protein Expression in Breast Cancer
Constantinos Savva et al.
CLINICAL BREAST CANCER (2021)
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Junhong Guan et al.
CANCER CELL (2021)
Analyzing mRNAsi-Related Genes Identifies Novel Prognostic Markers and Potential Drug Combination for Patients with Basal Breast Cancer
Kai Huang et al.
DISEASE MARKERS (2021)
ER-directed TREX1 limits cGAS activation at micronuclei
Lisa Mohr et al.
MOLECULAR CELL (2021)
Identification of a risk prediction model for clinical prognosis in HER2 positive breast cancer patients
Danyang Zhou et al.
GENOMICS (2021)
Identification of DNA Damage Repair-Associated Prognostic Biomarkers for Prostate Cancer Using Transcriptomic Data Analysis
Pai-Chi Teng et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Developing a Peptide That Inhibits DNA Repair by Blocking the Binding of Artemis and DNA Ligase IV to Enhance Tumor Radiosensitivity
Chu Zhu et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
Wen Zhou et al.
MOLECULAR CELL (2021)
Exonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma
Chang-shuai Zhou et al.
ONCOTARGETS AND THERAPY (2021)
BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression
Yu Li et al.
SCIENTIFIC REPORTS (2021)
Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
Amanda L. Gavin et al.
NATURE COMMUNICATIONS (2021)
The Role of Nucleases and Nucleic Acid Editing Enzymes in the Regulation of Self-Nucleic Acid Sensing
Pauline Santa et al.
FRONTIERS IN IMMUNOLOGY (2021)
Identification of a DNA Repair Gene Signature and Establishment of a Prognostic Nomogram Predicting Biochemical-Recurrence-Free Survival of Prostate Cancer
Gongwei Long et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2021)
Pan-cancer analysis of non-oncogene addiction to DNA repair
Luis Bermudez-Guzman
SCIENTIFIC REPORTS (2021)
Expression of immune-related genes as prognostic biomarkers for the assessment of osteosarcoma clinical outcomes
Junjie Guo et al.
SCIENTIFIC REPORTS (2021)
Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma
Ping Hou et al.
DIAGNOSTIC PATHOLOGY (2021)
Nucleases as molecular targets for cancer diagnosis
Alien Balian et al.
BIOMARKER RESEARCH (2021)
Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C
Samiur Rahman et al.
SCIENTIFIC REPORTS (2021)
Construction and validation of an RNA-binding protein-associated prognostic model for colorectal cancer
Yandong Miao et al.
PEERJ (2021)
TREX1 as a Novel Immunotherapeutic Target
Wayne O. Hemphill et al.
FRONTIERS IN IMMUNOLOGY (2021)
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
Guilherme Pedreira de Freitas Nader et al.
CELL (2021)
POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes
Luigi Magrin et al.
ONCOGENE (2021)
Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra
Hanns Leonhard Kaatsch et al.
SCIENTIFIC REPORTS (2021)
Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases
Paulina Prorok et al.
CELLS (2021)
Identification of a Novel Prognostic Gene Signature From the Immune Cell Infiltration Landscape of Osteosarcoma
Lei Fan et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma
Zhourui Ma et al.
BIOENGINEERED (2021)
Understanding APE1 cellular functions by the structural preference of exonuclease activities
Tung-Chang Liu et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)
Elevated EXO1 expression is associated with breast carcinogenesis and poor prognosis
Jingjing Liu et al.
ANNALS OF TRANSLATIONAL MEDICINE (2021)
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders
Amit L. Deshmukh et al.
JOURNAL OF HUNTINGTONS DISEASE (2021)
The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study
Mingyao Zhang et al.
JOURNAL OF CANCER (2021)
How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor
Teresa Ho et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
APE1 senses DNA single-strand breaks for repair and signaling
Yunfeng Lin et al.
NUCLEIC ACIDS RESEARCH (2020)
Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei
Mei Sim Lung et al.
BMC CANCER (2020)
Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer
Dongyun He et al.
MEDICAL SCIENCE MONITOR (2020)
Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review
Sami Belhadj et al.
HUMAN MUTATION (2020)
Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions
Samiur Rahman et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
The MRE11 complex: A versatile toolkit for the repair of broken DNA
Giordano Reginato et al.
DNA REPAIR (2020)
Role ofPOLEandPOLD1in familial cancer
Pilar Mur et al.
GENETICS IN MEDICINE (2020)
Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Eva Bartok et al.
IMMUNITY (2020)
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
John Maciejowski et al.
NATURE GENETICS (2020)
Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing inSetaria viridis
Trevor Weiss et al.
PLANT JOURNAL (2020)
TREX1-Apex predator of cytosolic DNA metabolism
Sean R. Simpson et al.
DNA REPAIR (2020)
TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A
Jun Ho Ko et al.
CELL REPORTS (2020)
EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3
Guang Yang et al.
JOURNAL OF CANCER (2020)
PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes
Shuji Akizuki et al.
ANNALS OF THE RHEUMATIC DISEASES (2019)
Exonuclease 1 expression is associated with clinical progression, metastasis, and survival prognosis of prostate cancer
Fei Luo et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression
Xiaobin Ma et al.
BREAST CANCER RESEARCH AND TREATMENT (2019)
POLE proofreading defects: Contributions to mutagenesis and cancer
Vivian S. Park et al.
DNA REPAIR (2019)
The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination
Jumi Park et al.
NUCLEIC ACIDS RESEARCH (2019)
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
Christoph Weigel et al.
CLINICAL EPIGENETICS (2019)
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta-analysis
Abdolkarim Moazeni-Roodi et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
Jadwiga Nieminuszczy et al.
MOLECULAR CELL (2019)
A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication
Chyuan-Chuan Wu et al.
NUCLEIC ACIDS RESEARCH (2019)
RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2)
Constantinos G. Broustas et al.
CARCINOGENESIS (2019)
Prevalence of Pathogenic Variants of FAN1 in More Than 5000 Patients Assessed for Genetic Predisposition to Colorectal, Breast, Ovarian, or Other Cancers
Alice Fievet et al.
GASTROENTEROLOGY (2019)
Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo
Bruna Prati et al.
SCIENTIFIC REPORTS (2019)
HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products
Swati Kumar et al.
JOURNAL OF VIROLOGY (2018)
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions
Sarah Sertic et al.
MOLECULAR CELL (2018)
Exonuclease EXD2 in mitochondrial translation
Brian M. Zid et al.
NATURE CELL BIOLOGY (2018)
APE1 deficiency promotes cellular senescence and premature aging features
Mengxia Li et al.
NUCLEIC ACIDS RESEARCH (2018)
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Theo A. Knijnenburg et al.
CELL REPORTS (2018)
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
Amanda L. Gavin et al.
NATURE IMMUNOLOGY (2018)
EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients
Yaoyao Dai et al.
CELL CYCLE (2018)
Werner Syndrome Protein and DNA Replication
Shibani Mukherjee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas
Borre Fevang et al.
CASE REPORTS IN IMMUNOLOGY (2018)
The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis
Lebin Song et al.
ARTHRITIS RESEARCH & THERAPY (2018)
The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation
H. Sun et al.
ONCOGENE (2017)
PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells
Long Gao et al.
ONCOLOGY REPORTS (2017)
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
Erkin Erdal et al.
GENES & DEVELOPMENT (2017)
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice
Tomomi Sakai et al.
JOURNAL OF AUTOIMMUNITY (2017)
Immune Diseases Associated with TREX1 and STING Dysfunction
Nan Yan
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2017)
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Andrew N. Blackford et al.
MOLECULAR CELL (2017)
Targeting phospholipase D in cancer, infection and neurodegenerative disorders
H. Alex Brown et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Control of structure-specific endonucleases to maintain genome stability
Pierre-Marie Dehe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
Maroof Hasan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Significant association of the EXO1 rs851797 polymorphism with clinical outcome of ovarian cancer
Tingyan Shi et al.
ONCOTARGETS AND THERAPY (2017)
FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
Antonio Porro et al.
NATURE COMMUNICATIONS (2017)
Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus
Anne Bothmer et al.
NATURE COMMUNICATIONS (2017)
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Claire Vanpouille-Box et al.
NATURE COMMUNICATIONS (2017)
rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis
Wei-Chiao Chen et al.
ONCOTARGET (2017)
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population
Yonghua Sang et al.
THORACIC CANCER (2017)
TREX1 dictates the immune fate of irradiated cancer cells
Claire Vanpouille-Box et al.
ONCOIMMUNOLOGY (2017)
Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses
Joan Manils et al.
SCIENTIFIC REPORTS (2017)
Structural and functional relationships of FAN1
Hyeonseok Jin et al.
DNA REPAIR (2017)
Putting p53 in Context
Edward R. Kastenhuber et al.
CELL (2017)
The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population
Renata Krupa et al.
DNA AND CELL BIOLOGY (2017)
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1)
Sergey S. Laev et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people
Yiming Zhang et al.
TUMOR BIOLOGY (2016)
Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer
Alyssa L. Smith et al.
CANCER LETTERS (2016)
Exonuclease 1 and its versatile roles in DNA repair
Guido Keijzers et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)
The Exonuclease Trex2 Shapes Psoriatic Phenotype
Joan Manils et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)
EXD2 promotes homologous recombination by facilitating DNA end resection
Ronan Broderick et al.
NATURE CELL BIOLOGY (2016)
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
Christophe Lachaud et al.
SCIENCE (2016)
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma
Shengkui Tan et al.
ONCOTARGET (2016)
FEN1 gene variants confer reduced risk of breast cancer in chinese women: A case-control study
Shuai Lin et al.
ONCOTARGET (2016)
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics
Bartosz Szczesny et al.
SCIENTIFIC REPORTS (2016)
FEN1 -69G>A and +4150G>T polymorphisms and breast cancer risk
Maryam Rezaei et al.
BIOMEDICAL REPORTS (2016)
Exonuclease 1-dependent and independent mismatch repair
Eva M. Goellner et al.
DNA REPAIR (2015)
Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair
Nuria Segui et al.
GASTROENTEROLOGY (2015)
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation
Maroof Hasan et al.
IMMUNITY (2015)
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
Raj Chari et al.
NATURE METHODS (2015)
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
Jessica L. Grieves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis
Joan Manils et al.
ONCOTARGET (2015)
Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China
Xingyuan Jiao et al.
SCIENTIFIC REPORTS (2015)
Granzyme A activates another way to die
Judy Lieberman
IMMUNOLOGICAL REVIEWS (2015)
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis
Hongtao Ren et al.
MOLECULAR AND CLINICAL ONCOLOGY (2015)
Human Apurinic/Apyrimidinic Endonuclease 1
Mengxia Li et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Association of functional FEN1 genetic variants and haplotypes and breast cancer risk
Zheng Lv et al.
GENE (2014)
Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis
Kejia Wang et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)
The 3′-5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response
Takuya Miyazaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity
Sicong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
DNA Repair and Redox Activities and Inhibitors of Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor 1 (APE1/Ref-1): A Comparative Analysis and Their Scope and Limitations toward Anticancer Drug Development
Gagandeep Kaur et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
Tarek M. A. Abdel-Fatah et al.
MOLECULAR ONCOLOGY (2014)
Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro
Shin-Hwar Wu et al.
MOLECULES (2014)
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
Carlos Cruchaga et al.
NATURE (2014)
The Significance of Exo1 K589E Polymorphism on Cancer Susceptibility: Evidence Based on a Meta-Analysis
Fujiao Duan et al.
PLOS ONE (2014)
Recombination and Replication
Aisha H. Syeda et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
Shweta Thakur et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2014)
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study
Francesca Damiola et al.
BREAST CANCER RESEARCH (2014)
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs
Maja T. Tomicic et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Cyclophosphamide Induces a Type I Interferon-Associated Sterile Inflammatory Response Signature in Cancer Patients' Blood Cells: Implications for Cancer Chemoimmunotherapy
Federica Moschella et al.
CLINICAL CANCER RESEARCH (2013)
Functional FEN1 genetic variants and haplotypes are associated with glioma risk
Yi-Dong Chen et al.
JOURNAL OF NEURO-ONCOLOGY (2013)
Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes
Lingchuan Hu et al.
NATURE (2013)
DNARepair Gene Patterns as Prognostic and Predictive Factors in Molecular Breast Cancer Subtypes
Libero Santarpia et al.
ONCOLOGIST (2013)
Functional Assessment of Population and Tumor-Associated APE1 Protein Variants
Jennifer L. Illuzzi et al.
PLOS ONE (2013)
Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Sonja Schaetzlein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Decrease in Abundance of Apurinic/Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells
Miriama Kruta et al.
STEM CELLS (2013)
Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer
Li Liu et al.
CARCINOGENESIS (2012)
Exonuclease 1 (EXO1) gene variation and melanoma risk
Fengju Song et al.
DNA REPAIR (2012)
Effect of autoimmune diseases on risk and survival in histology-specific lung cancer
Kari Hemminki et al.
EUROPEAN RESPIRATORY JOURNAL (2012)
Contributions of Rad9 to tumorigenesis
Constantinos G. Broustas et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
The significance of Exonuclease 1 K589E polymorphism on hepatocellular carcinoma susceptibility in the Turkish population: a case-control study
Suleyman Bayram et al.
MOLECULAR BIOLOGY REPORTS (2012)
DNA damage checkpoints in stem cells, ageing and cancer
Tobias Sperka et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
DNA end resection-Unraveling the tail
Eleni P. Mimitou et al.
DNA REPAIR (2011)
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis
Cheryl Jacobs et al.
HUMAN MOLECULAR GENETICS (2011)
Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome CRITICAL ROLE OF EXOG (5′-EXO/ENDONUCLEASE) IN THEIR REPAIR
Anne W. Tann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Age-Related Instability in Spermatogenic Cell Nuclear and Mitochondrial DNA Obtained From Apex1 Heterozygous Mice
Kristine S. Vogel et al.
MOLECULAR REPRODUCTION AND DEVELOPMENT (2011)
Functional regulation of FEN1 nuclease and its link to cancer
Li Zheng et al.
NUCLEIC ACIDS RESEARCH (2011)
Nucleases: diversity of structure, function and mechanism
Wei Yang
QUARTERLY REVIEWS OF BIOPHYSICS (2011)
MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer
Ananya Choudhury et al.
CANCER RESEARCH (2010)
Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer
Rachel Abbotts et al.
CANCER TREATMENT REVIEWS (2010)
p53 in cytoplasm exerts 3′→5′ exonuclease activity with dsRNA
Shai Grinberg et al.
CELL CYCLE (2010)
Impact of EXO1 Polymorphism in Susceptibility to Colorectal Cancer
Mahdi Montazer Haghighi et al.
GENETIC TESTING AND MOLECULAR BIOMARKERS (2010)
ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy
Kathryn G. Eby et al.
MOLECULAR CANCER (2010)
Exo1 Competes with Repair Synthesis, Converts NER Intermediates to Long ssDNA Gaps, and Promotes Checkpoint Activation
Michele Giannattasio et al.
MOLECULAR CELL (2010)
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage
Markus Christmann et al.
NUCLEIC ACIDS RESEARCH (2010)
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Emma Bolderson et al.
NUCLEIC ACIDS RESEARCH (2010)
Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans
Jana Kieper et al.
PROTEIN EXPRESSION AND PURIFICATION (2010)
Senescence evasion by MCF-7 human breast tumor-initiating cells
Feridoun Karimi-Busheri et al.
BREAST CANCER RESEARCH (2010)
A Polymorphism in the APE1 Gene Promoter is Associated with Lung Cancer Risk
Yen-Li Lo et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)
ARTEMIS Nuclease Facilitates Apoptotic Chromatin Cleavage
Sebastien Britton et al.
CANCER RESEARCH (2009)
Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
David Parra et al.
CANCER RESEARCH (2009)
Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein
Jinwoo Ahn et al.
CELL CYCLE (2009)
Single-Nucleotide Polymorphism of the Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan
Da-Tian Bau et al.
CHINESE JOURNAL OF PHYSIOLOGY (2009)
TREX1 acts in degrading damaged DNA from drug-treated tumor cells
Chuan-Jen Wang et al.
DNA REPAIR (2009)
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility
Juan Lu et al.
FASEB JOURNAL (2009)
Functional FEN1 Polymorphisms Are Associated with DNA Damage Levels and Lung Cancer Risk
Ming Yang et al.
HUMAN MUTATION (2009)
TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations
Lavinia C. Dumitrache et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)
Artemis is a negative regulator of p53 in response to oxidative stress
X. Zhang et al.
ONCOGENE (2009)
Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan
Ming-Hsui Tsai et al.
ORAL ONCOLOGY (2009)
Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells
Jun-Young Heo et al.
STEM CELLS (2009)
Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukernia:: consequences for the repair of DNA double-strand breaks
Annahita Sallmyr et al.
BLOOD (2008)
Rad9 has a functional role in human prostate carcinogenesis
Aiping Zhu et al.
CANCER RESEARCH (2008)
Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development
Zhishang Hu et al.
CANCER RESEARCH (2008)
The requirement of artemis in double-strand break repair depends on the type of DNA damage
Aya Kurosawa et al.
DNA AND CELL BIOLOGY (2008)
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner
Qin Wen et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population:: A case-control analysis*
Guangfu Jin et al.
LUNG CANCER (2008)
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
Eleni P. Mimitou et al.
NATURE (2008)
EXOG, a novel paralog of Endonuclease G in higher eukaryotes
Iwona A. Cymerman et al.
NUCLEIC ACIDS RESEARCH (2008)
p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis
T. Kawase et al.
ONCOGENE (2008)
DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment
Takeshi Yuki et al.
ONCOLOGY REPORTS (2008)
Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers
Purnima Singh et al.
MOLECULAR CANCER RESEARCH (2008)
Exonucleolytic degradation of RNA by p53 protein in cytoplasm
Mary Bakhanashvili et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2008)
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
Yun-Gui Yang et al.
CELL (2007)
Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells
Ming-Jiu Chen et al.
CANCER RESEARCH (2007)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Min Ae Lee-Kirsch et al.
NATURE GENETICS (2007)
Protein expression profiling and molecular classification of gastric cancer by the tissue array method
Hye Seung Lee et al.
CLINICAL CANCER RESEARCH (2007)
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Li Zheng et al.
NATURE MEDICINE (2007)
Multifunctional human Apurinic/Apyrimidinic endonuclease 1: role of additional functions
N. S. Dyrkheevaa et al.
MOLECULAR BIOLOGY (2007)
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome
Gillian Rice et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score
John S. Lam et al.
BJU INTERNATIONAL (2006)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
Yanick J. Crow et al.
NATURE GENETICS (2006)
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death
Dipanjan Chowdhury et al.
MOLECULAR CELL (2006)
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
Ruben Agrelo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Diagnostic and prognostic value of cell-cycle regulatory genes in malignant thyroid neoplasms
E Kebebew et al.
WORLD JOURNAL OF SURGERY (2006)
Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis
JH Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Phospholipase D: a lipid centric review
GM Jenkins et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer
CK Cheng et al.
CANCER RESEARCH (2005)
The human TREX2 3′→5′-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis
FW Perrino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells
Y Maniwa et al.
CANCER (2005)
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability
G Giannini et al.
ONCOGENE (2004)
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
S Rooney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The role of endogenous and exogenous DNA damage and mutagenesis
EC Friedberg et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2004)
Spontaneous mutagenesis is enhanced in Apex heterozygous mice
J Huamani et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis
M Morita et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Deletion of mouse Rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality
KM Hopkins et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers
JE Armes et al.
ONCOGENE (2004)
Human Deoxyribonucleases
AG Baranovskii et al.
BIOCHEMISTRY-MOSCOW (2004)
Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer
M Sato et al.
ONCOGENE (2003)
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
E Larsen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling
P Roos-Mattjus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Defective DNA repair and increased genomic instability in artemis-deficient murine cells
S Rooney et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
KC Wei et al.
GENES & DEVELOPMENT (2003)
p53-associated 3′→5′ exonuclease activity in nuclear and cytoplasmic compartments of cells
L Gila et al.
ONCOGENE (2003)
Structure and function of nucleases in DNA repair: shape, grip and blade of the DNA scissors
T Nishino et al.
ONCOGENE (2002)
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
S Rooney et al.
MOLECULAR CELL (2002)
High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading
RE Goldsby et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
M Kucherlapati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
YM Ma et al.
CELL (2002)
Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms
Y Wu et al.
GASTROENTEROLOGY (2001)
Structure and expression of the TREX1 and TREX2 3′→5′ exonuclease genes
DJ Mazur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
D Moshous et al.
CELL (2001)
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
YH Zuo et al.
NUCLEIC ACIDS RESEARCH (2001)
The DNA damage response: putting checkpoints in perspective
BBS Zhou et al.
NATURE (2000)