4.6 Review

New Insights into Hippo/YAP Signaling in Fibrotic Diseases

Related references

Note: Only part of the references are listed.
Article Physiology

Combined control of the fibroblast contractile program by YAP and TAZ

Patrick A. Link et al.

Summary: YAP and TAZ play important roles in the contractile function of fibroblasts. Combined knockdown of YAP and TAZ has stronger effects on transcriptional activation and contraction in fibroblasts, potentially through cooperation or redundancy. The genes affected by combined knockdown are mainly involved in contraction and migration. In patients with idiopathic pulmonary fibrosis, combined knockdown of YAP and TAZ reduces the expression of three cytoskeletal genes, indicating a greater impact on contractile function.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2022)

Article Gastroenterology & Hepatology

Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis

Jie Qing et al.

Summary: DRD2 antagonism selectively targets YAP-dependent fibrogenic crosstalk between macrophages and CTGF(+)VCAM1(+) vascular niche, promoting liver regeneration over fibrosis in both rodent and large animal models.

JOURNAL OF HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

Hippo signalling in the liver: role in development, regeneration and disease

Jacquelyn O. Russell et al.

Summary: The Hippo signalling pathway plays a crucial role in liver biology, including development, cell fate determination, homeostatic function, and regeneration. Pathological activation of the downstream YAP-TAZ signalling has been implicated in chronic liver diseases, making the development of inhibitors for this pathway important.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Article Medicine, Research & Experimental

Myofibroblast YAP/TAZ activation is a key in

Xiaolin He et al.

Summary: This article explores the role of myofibroblast YAP and TAZ in organ fibrosis and the kinetics of their activation. The study found that YAP and TAZ were activated early after organ injury and that this activation was sustained. Additionally, the research demonstrated the critical importance of myofibroblast YAP/TAZ in driving progressive scarring in the kidney, lung, and liver.

JCI INSIGHT (2022)

Article Cardiac & Cardiovascular Systems

Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function

Masum M. Mia et al.

Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.

CARDIOVASCULAR RESEARCH (2022)

Review Biochemistry & Molecular Biology

Emerging roles of the Hippo signaling pathway in modulating immune response and inflammation-driven tissue repair and remodeling

Masum M. Mia et al.

Summary: This review summarizes recent findings on the involvement of the Hippo signaling pathway in modulating the immune response in different acute and chronic inflammatory diseases, and its impact on tissue repair and remodeling.

FEBS JOURNAL (2022)

Article Chemistry, Multidisciplinary

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury

Dan Xu et al.

Summary: This study revealed that sustained activation of YAP in the post-acute phase of AKI is associated with renal functional deterioration and fibrosis, with KLF4 being responsible for this persistence. Blocking the activation of the KLF4-YAP pathway may be a way to prevent the transition of AKI into CKD.

ACTA PHARMACOLOGICA SINICA (2021)

Article Medicine, Research & Experimental

Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway

Wenjing Du et al.

Summary: The study demonstrated that icariin can alleviate bleomycin-induced pulmonary fibrosis in rats by inhibiting YAP, a core transcriptional regulator of the Hippo pathway.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway

Chunxue Li et al.

Summary: This study identified a new mechanism by which Res inhibits hepatic stellate cell (HSC) activation, with the Hippo pathway playing a role in this process.

MEDIATORS OF INFLAMMATION (2021)

Article Gastroenterology & Hepatology

Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis

Elisabeth Verboven et al.

Summary: YAP/TAZ are not essential for liver development and regeneration in hepatocytes, but they indirectly contribute to liver regeneration by maintaining bile duct integrity and ensuring immune cell recruitment and function.

GASTROENTEROLOGY (2021)

Article Multidisciplinary Sciences

Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload

Dan Shao et al.

Summary: The study revealed that Lats2 plays a crucial role in the heart in response to stress, promoting cardiomyocyte apoptosis through a p53-dependent mechanism. Lats2+/- mice showed attenuation of cardiac hypertrophy and dysfunction induced by TAC, with suppressed apoptosis.

SCIENTIFIC REPORTS (2021)

Article Cardiac & Cardiovascular Systems

SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

Natalie M. Landry et al.

Summary: The study explores the regulatory role of SKI in cardiac fibroblast activation and its interaction with the TAZ protein, shedding light on the unique physiology of cardiac fibroblasts and the relationship between SKI expression and cell phenotype. The findings indicate that SKI's ability to modulate cardiac fibroblast activation is partially mediated by Hippo signaling pathways, highlighting the complex network involved in fibrotic processes in the heart.

BASIC RESEARCH IN CARDIOLOGY (2021)

Article Pharmacology & Pharmacy

Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice

Junjie Zhang et al.

Summary: The study revealed that Angiotensin II can activate the renal YAP pathway, leading to hypertensive renal inflammation and fibrosis, suggesting that YAP could be a potential target for prevention and treatment of hypertensive renal diseases.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

Article Cell & Tissue Engineering

Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

Ian J. Penkala et al.

Summary: The regeneration of the architecturally complex alveolar niche of the lung requires precise temporal and spatial control of epithelial cell behavior. Injury can result in a permanent reduction in gas exchange surface area and respiratory function. The plasticity of alveolar type 1 cells plays a crucial role in driving regeneration, particularly in the early postnatal period.

CELL STEM CELL (2021)

Article Multidisciplinary Sciences

AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis

Jamie Francisco et al.

Summary: Fibrosis is a hallmark of heart disease and the mechanisms that regulate fibroblast differentiation and fibrotic responses are not fully understood. Studies show that overexpression of YAP in cardiac fibroblasts can lead to increased fibrosis and inflammation, negatively impacting cardiac function.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation

Maryam Sharifi-Sanjani et al.

Summary: The study indicates that Yap is elevated in LV tissue of HF patients, associated with down-regulation of its upstream inhibitor LATS1 and upregulation of the fibrosis marker CTGF. In vitro application of profibrotic stress to human cardiac fibroblasts increased Yap levels, promoted cell proliferation and collagen I production, and altered mTOR pathway activity, suggesting a potential role of Yap in LV remodeling in HF.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease

Weijun Ou et al.

Summary: Intestinal fibrosis leading to intestinal obstruction in Crohn's disease may be associated with YAP/TAZ activation, and ROCK1 inhibitor could alleviate intestinal fibrosis by inhibiting YAP/TAZ, serving as a potential therapeutic strategy for suppressing intestinal fibrosis in Crohn's disease.

EBIOMEDICINE (2021)

Article Chemistry, Medicinal

Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis

Yafeng Ren et al.

Summary: This study demonstrates that selectively targeting YAP signaling in endothelial cells may ameliorate kidney fibrosis. The research suggests that selective antagonization of endothelial YAP activity could provide new avenues for bypassing kidney fibrosis.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Article Multidisciplinary Sciences

GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Katarina Zmajkovicova et al.

PLOS ONE (2020)

Article Physiology

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation

Aja Aravamudhan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Daniela M. Santos et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Article Cell Biology

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Sarah Alsamman et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Cell Biology

Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis

Raffaele Strippoli et al.

CELL DEATH & DISEASE (2020)

Article Cardiac & Cardiovascular Systems

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Jamie Francisco et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Review Immunology

Regeneration and repair in the healing lung

Andrew Lucas et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Lovastatin attenuates angiotensin II induced cardiovascular fibrosis through the suppression of YAP/TAZ signaling

Pei Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

Ryan LaCanna et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Gastroenterology & Hepatology

Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury

Yuan Liu et al.

JOURNAL OF HEPATOLOGY (2019)

Review Cell Biology

The Hippo Signaling Pathway in Cardiac Development and Diseases

Masum M. Mia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Cell Biology

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Andrew J. Haak et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF

Yingzhun Chen et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biotechnology & Applied Microbiology

Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway

Jian Zhang et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Biochemistry & Molecular Biology

Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1 signaling

Chenxi Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Zobair Younossi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury

Takanori Konishi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

Sandybell Anorga et al.

FASEB JOURNAL (2018)

Article Gastroenterology & Hepatology

Pathogenesis of non-alcoholic fatty liver disease mediated by YAP

Ping Chen et al.

HEPATOLOGY INTERNATIONAL (2018)

Article Biochemistry & Molecular Biology

Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway

Xiaoguang Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Dermatology

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

Tetsuo Toyama et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Review Medicine, General & Internal

Idiopathic Pulmonary Fibrosis

David J. Lederer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Biochemistry & Molecular Biology

Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis

Yuan Gui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Urology & Nephrology

EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI

Jianchun Chen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Biochemistry & Molecular Biology

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

Sushant Bangru et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Medicine, General & Internal

Idiopathic Pulmonary Fibrosis (IPF): An Overview

Shaney L. Barratt et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Article Ophthalmology

YAP/TAZ Are Essential for TGF-β2-Mediated Conjunctival Fibrosis

Akiko Futakuchi et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Article Medicine, Research & Experimental

Active epithelial Hippo signaling in idiopathic pulmonary fibrosis

Jason J. Gokey et al.

JCI INSIGHT (2018)

Article Medicine, Research & Experimental

Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction

Vimal Ramjee et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Urology & Nephrology

Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis

Ming Liang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Medicine, General & Internal

Idiopathic pulmonary fibrosis

Luca Richeldi et al.

LANCET (2017)

Article Biochemistry & Molecular Biology

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis

Janet Y. Leung et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Hippo pathway deficiency reverses systolic heart failure after infarction

John P. Leach et al.

NATURE (2017)

Article Multidisciplinary Sciences

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

Satoshi Noguchi et al.

SCIENTIFIC REPORTS (2017)

Article Urology & Nephrology

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis

Stephen G. Szeto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Multidisciplinary Sciences

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Katherine Martin et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Eunjeong Seo et al.

SCIENTIFIC REPORTS (2016)

Article Pathology

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

Bram Piersma et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

Article Physiology

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Fei Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

Fa-Xing Yu et al.

Article Gastroenterology & Hepatology

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

Siddharth Singh et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways

Ekihiro Seki et al.

HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Inge Mannaerts et al.

JOURNAL OF HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

Mariana Verdelho Machado et al.

JOURNAL OF HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

Dean Yimlamai et al.

JOURNAL OF HEPATOLOGY (2015)

Review Medicine, General & Internal

Fibrosis - A Common Pathway to Organ Injury and Failure

Don C. Rockey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Andrew E. Vaughan et al.

NATURE (2015)

Review Medicine, General & Internal

Signaling in fibrosis: TGF-beta, wNT, and YAP/TAZ converge

Bram Piersma et al.

FRONTIERS IN MEDICINE (2015)

Article Biochemistry & Molecular Biology

Hippo Pathway Activity Influences Liver Cell Fate

Dean Yimlamai et al.

Article Gastroenterology & Hepatology

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

Tom Luedde et al.

GASTROENTEROLOGY (2014)

Article Medicine, General & Internal

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Immunology

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Medicine, Research & Experimental

Type 2 alveolar cells are stem cells in adult lung

Christina E. Barkauskas et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Gastroenterology & Hepatology

Decoding cell death signals in liver inflammation

Catherine Brenner et al.

JOURNAL OF HEPATOLOGY (2013)

Article Gastroenterology & Hepatology

Yes-associated protein regulates the hepatic response after bile duct ligation

Haibo Bai et al.

HEPATOLOGY (2012)

Article Pharmacology & Pharmacy

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Robert H. Scannevin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Review Critical Care Medicine

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

Brett Ley et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Review Developmental Biology

Hippo signaling: growth control and beyond

Georg Halder et al.

DEVELOPMENT (2011)

Article Medicine, Research & Experimental

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

Dominic P. Del Re et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

Hai Song et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Li Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Kwang-Pyo Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Oncology

The myofibroblast in wound healing and fibrocontractive diseases

G Gabbiani

JOURNAL OF PATHOLOGY (2003)