Journal
CELLS
Volume 11, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/cells11152459
Keywords
cytoskeleton; endocytosis; evolution; spectrin
Categories
Funding
- National Natural Science Foundation of China [31470716, 31000323, 31070672]
- Natural Science Foundation of Jiangsu Province [BK20131272]
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This article summarizes the role of spectrin in endocytosis in different types of cells, focusing on its post-translational modification, movement/rearrangement, elimination, and meshwork fencing.
Cytoskeletal spectrin is found in (non)erythroid cells. Eukaryotic endocytosis takes place for internalizing cargos from extracellular milieu. The role of spectrin in endocytosis still remains poorly understood. Here, I summarize current knowledge of spectrin function, spectrin-based cytoskeleton and endocytosis of erythrocytes, and highlight how spectrin contributes to endocytosis and working models in different types of cells. From an evolutionary viewpoint, I discuss spectrin and endocytosis in a range of organisms, particularly in plants and yeast where spectrin is absent. Together, the role of spectrin in endocytosis is related to its post-translational modification, movement/rearrangement, elimination (by proteases) and meshwork fencing.
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