Journal
CELLS
Volume 11, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/cells11132084
Keywords
microbiome; Akkermansia sp; metabolic health
Categories
Funding
- IFF
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This study identifies and characterizes a novel Akkermansia species, which shows significant differences in fatty acid profile and carbon utilization compared to a known type strain. The study finds that this novel strain improves metabolic markers and suggests a potential novel mechanism for supporting metabolic and cognitive health through the production of agmatine. The findings highlight the therapeutic potential of this novel Akkermansia species for managing metabolic diseases.
Akkermansia muciniphila is a well-known bacterium with the ability to degrade mucin. This metabolic capability is believed to play an important role in the colonization of this bacterium in the gut. In this study, we report the identification and characterization of a novel Akkermansia sp. DSM 33459 isolated from human feces of a healthy donor. Phylogenetic analysis based on the genome-wide average nucleotide identity indicated that the Akkermansia sp. DSM 33459 has only 87.5% similarity with the type strain A. muciniphila ATCC BAA-835. Akkermansia sp. DSM 33459 showed significant differences in its fatty acid profile and carbon utilization as compared to the type strain. The Akkermansia sp. DSM 33459 strain was tested in a preclinical obesity model to determine its effect on metabolic markers. Akkermansia sp. DSM 33459 showed significant improvement in body weight, total fat weight, and resistin and insulin levels. Interestingly, these effects were more pronounced with the live form as compared to a pasteurized form of the strain. The strain showed production of agmatine, suggesting a potential novel mechanism for supporting metabolic and cognitive health. Based on its phenotypic features and phylogenetic position, it is proposed that this isolate represents a novel species in the genus Akkermansia and a promising therapeutic candidate for the management of metabolic diseases.
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