4.6 Review

Restructuring of Lamina-Associated Domains in Senescence and Cancer

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

A deep hybrid learning pipeline for accurate diagnosis of ovarian cancer based on nuclear morphology

Duhita Sengupta et al.

Summary: Nuclear morphological features are crucial for clinical diagnostic approaches in analyzing cancer cells. This study utilized machine learning techniques and deep learning methods to correlate nuclear morphometric features with nuclear lamin protein distribution and successfully differentiate between normal and ovarian cancer tissues.

PLOS ONE (2022)

Review Cell Biology

Chromatin basis of the senescence-associated secretory phenotype

Xue Hao et al.

Summary: Cellular senescence is a stable cell growth arrest characterized by the secretion of inflammatory cytokines, chemokines, and growth factors, known as SASP. Recent studies have shown that chromatin plays a key role in regulating SASP. Targeting chromatin regulatory mechanisms to alter SASP could be a potential approach for combating cancers and achieving healthy aging.

TRENDS IN CELL BIOLOGY (2022)

Article Oncology

Role of Lamin A and emerin in maintaining nuclear morphology in different subtypes of ovarian epithelial cancer

Shiori Watabe et al.

Summary: The present study investigated the correlation between nuclear morphology and nuclear membrane protein expression in different subtypes of ovarian epithelial cancer. The results showed that Lamin A plays a more significant role than emerin in maintaining nuclear morphology, and different subtypes of tumors have distinct nuclear shape characteristics.

ONCOLOGY LETTERS (2022)

Article Multidisciplinary Sciences

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

Rafal Czapiewski et al.

Summary: This study reveals the critical role of nuclear envelope protein Tmem120a in the establishment of fat genome organization. The deficiency of Tmem120a disrupts the organization of fat genes, leading to suppressed lipid metabolism pathway and induced expression of myogenic genes.

NATURE COMMUNICATIONS (2022)

Review Biotechnology & Applied Microbiology

The functional impact of nuclear reorganization in cellular senescence

Azucena Rocha et al.

Summary: The article provides an overview of the nuclear changes that occur in different forms of senescence, including changes in chromatin state and composition, three-dimensional organization of the genome, nuclear envelope, and accessibility of repetitive genomic regions. These changes are shared across all forms of senescence, indicating that nuclear organization plays a fundamental role in the senescent state and interaction of senescent cells with the surrounding tissue.

BRIEFINGS IN FUNCTIONAL GENOMICS (2022)

Review Cell Biology

Epigenetic Regulation of Cellular Senescence

Jack Crouch et al.

Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).

CELLS (2022)

Article Cell Biology

Cancer-associated chromatin variants uncover the oncogenic role of transposable elements

Giacomo Grillo et al.

Summary: The diverse cell states found in human tissue are a result of variations in chromatin, which are influenced by DNA elements. Oncogenesis is caused by changes in chromatin states over cancer-associated DNA elements. By studying repetitive DNA elements, we can gain insights into their role in oncogenesis and advance precision medicine in cancer genomics.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

Article Cell Biology

Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer

Ivana Y. Quiroga et al.

Summary: This review focuses on discussing oncogenic fusion proteins that alter 3D chromatin structure through liquid-liquid phase separation mechanism, and the potential of this phenomenon as a mechanism of oncogenesis.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

Review Oncology

3D chromatin architecture and transcription regulation in cancer

Siwei Deng et al.

Summary: This review discusses the importance of three-dimensional chromatin structures in biological processes and diseases, as well as the key structural protein elements involved in chromatin interactions. The recent development of technologies and bioinformatics approaches for studying chromatin interactions in gene expression regulation is also summarized.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Biotechnology & Applied Microbiology

Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage

Julia Madsen-Osterbye et al.

Summary: LADs are predictable structural features of adipose nuclear architecture that restrain non-adipogenic genes, and their repositioning partially correlates with gene expression changes during adipogenesis.

GENOME BIOLOGY (2022)

Article Oncology

Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy

Satyen H. Gohil et al.

Summary: Advances in single-cell analysis technologies have enabled the study of tumor heterogeneity, interactions between immune cells and tumor cells, and the evolutionary trajectory of each tumor. Multidimensional biomarker signatures will be crucial for guiding clinical decision-making for cancer patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Cell Biology

Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins

Mark Kittisopikul et al.

Summary: The study demonstrates that lamin isoforms and nucleoporins work together to maintain the normal organization of lamin meshworks and NPC within the nuclear envelope; Specific lamin isoforms are involved in regulating the number of NPCs; The spatial association between lamin isoform fibers and NPCs remains intact in nuclei with knockout lamin isoforms.

JOURNAL OF CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

The nuclear periphery is a scaffold for tissue-specific enhancers

Cheryl L. Smith et al.

Summary: Nuclear architecture influences gene regulation and cell identity by controlling the three-dimensional organization of genes and their distal regulatory sequences. KODs, a novel type of nuclear peripheral chromatin domain enriched for tissue-specific transcriptional enhancers, show limited Lamin B interaction and are characterized by low gene expression and enhancers in an inactive or poised state. These KODs may play a role in regulating spatiotemporal gene expression programs during differentiation and development.

NUCLEIC ACIDS RESEARCH (2021)

Review Cell Biology

The Paradoxical Role of Cellular Senescence in Cancer

Jing Yang et al.

Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Endocrinology & Metabolism

The metabolic roots of senescence: mechanisms and opportunities for intervention

Christopher D. Wiley et al.

Summary: Cellular senescence involves a permanent proliferative arrest and the release of biologically active molecules known as SASP. Studies show that senescence and SASP are sensitive to metabolic states, potentially driving phenotypes associated with metabolic dysfunction. Effective interventions may disrupt the feedback loop in which cellular senescence promotes metabolic diseases.

NATURE METABOLISM (2021)

Article Genetics & Heredity

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Florian Koehler et al.

GENOME MEDICINE (2020)

Article Biochemistry & Molecular Biology

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence

Satish Sati et al.

MOLECULAR CELL (2020)

Review Biotechnology & Applied Microbiology

Lamina-associated domains: peripheral matters and internal affairs

Nolwenn Briand et al.

GENOME BIOLOGY (2020)

Article Multidisciplinary Sciences

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco et al.

NATURE (2019)

Article Cell Biology

p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Min-Ho Yoon et al.

CELL DEATH & DISEASE (2019)

Article Biochemistry & Molecular Biology

Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

Christ Leemans et al.

Article Immunology

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET

Yanhan Jia et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Cell Biology

Two major mechanisms of chromosome organization

Leonid A. Mirny et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Review Cell Biology

Genome Organization in and around the Nucleolus

Cristiana Bersaglieri et al.

CELLS (2019)

Article Cell Biology

Polymer Modeling Predicts Chromosome Reorganization in Senescence

Michael Chiang et al.

CELL REPORTS (2019)

Review Genetics & Heredity

Coaching from the sidelines: the nuclear periphery in genome regulation

Abigail Buchwalter et al.

NATURE REVIEWS GENETICS (2019)

Article Multidisciplinary Sciences

Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

Osamu Iwasaki et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions

Henri Niskanen et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

Sofia A. Quinodoz et al.

Article Genetics & Heredity

Challenges and guidelines toward 4D nucleome data and model standards

Marc A. Marti-Renom et al.

NATURE GENETICS (2018)

Article Multidisciplinary Sciences

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

Laura Pascual-Reguant et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

Yanan Zhang et al.

NATURE COMMUNICATIONS (2018)

Review Genetics & Heredity

Organizational principles of 3D genome architecture

M. Jordan Rowley et al.

NATURE REVIEWS GENETICS (2018)

Article Biochemistry & Molecular Biology

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence

Christelle Lenain et al.

GENOME RESEARCH (2017)

Editorial Material Cell Biology

Lamins in the nuclear interior - life outside the lamina

Nana Naetar et al.

JOURNAL OF CELL SCIENCE (2017)

Article Multidisciplinary Sciences

The molecular architecture of lamins in somatic cells

Yagmur Turgay et al.

NATURE (2017)

Review Genetics & Heredity

DNA Methylation, Nuclear Organization, and Cancer

Bhavani P. Madakashira et al.

FRONTIERS IN GENETICS (2017)

Article Biochemistry & Molecular Biology

Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis

Pablo E. Garcia-Nieto et al.

EMBO JOURNAL (2017)

Review Oncology

Context-dependent effects of cellular senescence in cancer development

Pacome Lecot et al.

BRITISH JOURNAL OF CANCER (2016)

Article Cell & Tissue Engineering

Nuclear Lamins in Cancer

Jerome Irianto et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

Review Genetics & Heredity

The Chromatin Landscape of Cellular Senescence

Steven W. Criscione et al.

TRENDS IN GENETICS (2016)

Article Multidisciplinary Sciences

Reorganization of chromosome architecture in replicative cellular senescence

Steven W. Criscione et al.

SCIENCE ADVANCES (2016)

Review Cell Biology

Nuclear membrane diversity: underlying tissue-specific pathologies in disease?

Howard J. Worman et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B

Torunn Ronningen et al.

GENOME RESEARCH (2015)

Article Cell Biology

Global Reorganization of the Nuclear Landscape in Senescent Cells

Tamir Chandra et al.

CELL REPORTS (2015)

Article Cell Biology

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

Joe Swift et al.

JOURNAL OF CELL SCIENCE (2014)

Article Biochemistry & Molecular Biology

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations

Eivind Lund et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

Ashley M. Wood et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

Wouter Meuleman et al.

GENOME RESEARCH (2013)

Article Cell Biology

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

Oliver Dreesen et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Review Cell Biology

The nuclear lamins: flexibility in function

Brian Burke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Review Oncology

Higher order chromatin organization in cancer

Karen L. Reddy et al.

SEMINARS IN CANCER BIOLOGY (2013)

Article Biochemistry & Molecular Biology

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

Joseph M. Zullo et al.

Article Biochemistry & Molecular Biology

A Landscape of Driver Mutations in Melanoma

Eran Hodis et al.

Article Cell Biology

Lamin B1 loss is a senescence-associated biomarker

Adam Freund et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Article Cell Biology

The role of nuclear lamin B1 in cell proliferation and senescence

Takeshi Shimi et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

Oliver G. McDonald et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

Daan Peric-Hupkes et al.

MOLECULAR CELL (2010)

Article Biochemistry & Molecular Biology

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

Ignacio Gonzalez-Suarez et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

K. L. Reddy et al.

NATURE (2008)

Article Multidisciplinary Sciences

Lamin A/C Is a Risk Biomarker in Colorectal Cancer

Naomi D. Willis et al.

PLOS ONE (2008)

Review Cell Biology

A-type lamins: Guardians of the soma?

CJ Hutchison et al.

NATURE CELL BIOLOGY (2004)