4.6 Review

Science CommuniCa2+tion Developing Scientific Literacy on Calcium: The Involvement of CRAC Currents in Human Health and Disease

Related references

Note: Only part of the references are listed.
Article Oncology

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells

Jose Sanchez-Collado et al.

Summary: The expression ratio of Orai1:Orai2 varies in different breast cancer cells, and Orai2 plays a crucial role in cell cycle progression and apoptosis resistance.

CANCERS (2022)

Review Cell Biology

Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies

Sascha Berlansky et al.

Summary: This article provides insights into SARS-CoV-2 and COVID-19, discussing vaccine-related issues, breakthrough infections, and the threat of immune escape variants. Additionally, it highlights the important role of calcium signaling in viral infections and explores treatment strategies that exploit the virus's dependence on calcium signals.

CELLS (2022)

Article Oncology

ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Shayi Wu et al.

Summary: This study reveals the upregulation of ORAI2 in lymph node metastasis of gastric cancer, and its role in cell proliferation and migration. Clinical data shows a correlation between ORAI2-positive cells in gastric cancer tissues and poor prognosis. ORAI2 promotes metastasis of gastric cancer cells through activation of PI3K/Akt signaling pathway and focal adhesion disassembly at the cell's rear-edge.

CANCER RESEARCH (2021)

Article Cell Biology

Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms

Mohamed Chamlali et al.

Summary: Orai3 regulates breast cancer cell migration through a Ca2+-dependent modulation of cell adhesive capacities and a Ca2+-independent regulation of the actin cytoskeleton via focal adhesion kinase (FAK).

CELLS (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+

Alex L. Lai et al.

Summary: Coronaviruses, including SARS-CoV-2, pose a major infectious disease threat, with differences in membrane ordering and hydrophobicity potentially influencing their ability to infect host cells. The SARS-2 FP shows increased membrane ordering and calcium dependency compared to SARS-1, possibly due to its greater hydrophobicity. The calcium binding properties of the SARS-2 FP suggest potential therapeutic targets to inhibit viral entry.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Review Pharmacology & Pharmacy

Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers

Yan Chang et al.

Summary: The review discusses the impact of dysregulated store-operated calcium entry (SOCE) on gastroesophageal cancers, including its role in cancer cell proliferation, migration, invasion, and stemness maintenance. Efforts towards developing more specific and potent SOCE inhibitors as a new set of chemotherapeutic drugs for targeted therapy or adjuvant treatment to overcome drug resistance in gastroesophageal cancers are also highlighted.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma

Charlotte Dubois et al.

Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Oncology

Store-operated Ca2+ entry as a key oncogenic Ca2+ signaling driving tumor invasion-metastasis cascade and its translational potential

Jiazhang Wei et al.

Summary: Recent studies have shown that alterations in SOCE play a critical role in tumor metastasis, with dysregulated expression of STIM/ORAI potentially serving as an indicator of poor prognosis. SOCE contributes significantly to EMT, tumor cell migration and invasion, and angiogenesis, suggesting it could be a feasible target for cancer treatment.

CANCER LETTERS (2021)

Review Genetics & Heredity

Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer

Mohamed Chamlali et al.

Summary: This review aims to summarize the findings on store-independent Ca2+ entry (SICE) in the field of breast cancer progression, as most literature focuses on store-dependent Ca2+ entry, neglecting the role of SICE.

GENES (2021)

Review Pharmacology & Pharmacy

Calcium Permeable Channels in Cancer Hallmarks

Sendoa Tajada et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Oncology

Targeting the Calcium Signalling Machinery in Cancer

Jason I. E. Bruce et al.

CANCERS (2020)

Review Cell Biology

CRAC channel regulation of innate immune cells in health and disease

Regina A. Clemens et al.

CELL CALCIUM (2019)

Review Cell Biology

ORAI channels in cellular remodeling of cardiorespiratory disease

Martin Johnson et al.

CELL CALCIUM (2019)

Editorial Material Cell Biology

Calcium signalling in health and disease

Anant B. Parekh

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Review Cell Biology

Store-operated calcium entry in thrombosis and thrombo-inflammation

Elmina Mammadova-Bach et al.

CELL CALCIUM (2019)

Review Cell Biology

Calcium signalling and breast cancer

Choon Leng So et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Review Cell Biology

Neuronal calcium signaling via store-operated channels in health and disease

Tomasz Wegierski et al.

CELL CALCIUM (2018)

Review Immunology

Ion channelopathies of the immune system

Martin Vaeth et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

Review Physiology

ION CHANNELS IN CANCER: ARE CANCER HALLMARKS ONCOCHANNELOPATHIES?

Natalia Prevarskaya et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Cell Biology

ORAI channels and cancer

Silke B. Chalmers et al.

CELL CALCIUM (2018)

Review Cell Biology

Calcium release-activated calcium channels and pain

Yixiao Mei et al.

CELL CALCIUM (2018)

Article Cell Biology

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia

Shella Saint Fleur-Lominy et al.

CELL REPORTS (2018)

Review Oncology

The calcium-cancer signalling nexus

Gregory R. Monteith et al.

NATURE REVIEWS CANCER (2017)

Article Multidisciplinary Sciences

Variations in ORAI1 Gene Associated with Kawasaki Disease

Yoshihiro Onouchi et al.

PLOS ONE (2016)

Article Genetics & Heredity

Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome

Gilles Morin et al.

HUMAN MUTATION (2014)

Article Multidisciplinary Sciences

Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration

Masanari Umemura et al.

PLOS ONE (2014)

Review Biology

Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?

Natalia Prevarskaya et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Review Pharmacology & Pharmacy

Use of rodents as models of human diseases

Thierry F. Vandamme

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2014)

Review Biochemistry & Molecular Biology

The STIM1/Orai signaling machinery

Marc Fahrner et al.

CHANNELS (2013)

Article Biochemistry & Molecular Biology

Orai3 is an estrogen receptor alpha-regulated Ca2+ channel that promotes tumorigenesis

Rajender K. Motiani et al.

FASEB JOURNAL (2013)

Article Oncology

Calcium intake is not related to breast cancer risk among Singapore Chinese women

Jingmei Li et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

Article Physiology

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

Rajender K. Motiani et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2013)

Article Dermatology

ORAI1 Ca2+ Channels Control Endothelin-1-Induced Mitogenesis and Melanogenesis in Primary Human Melanocytes

Hedwig Stanisz et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Article Multidisciplinary Sciences

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Tomohiko Murakami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Oncology

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

Damara McAndrew et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Review Physiology

Polarized calcium signaling in exocrine gland cells

Ole H. Petersen et al.

ANNUAL REVIEW OF PHYSIOLOGY (2008)

Article Cell Biology

TRPV4-mediated calcium influx regulates terminal differentiation of Osteoclasts

Ritsuko Masuyama et al.

CELL METABOLISM (2008)

Article Biochemistry & Molecular Biology

Differential expression of E-cadherin gene in human neuroepithelial tumors

F. J. N. Motta et al.

GENETICS AND MOLECULAR RESEARCH (2008)

Article Biochemistry & Molecular Biology

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation

Martin Muik et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Calcium signaling

David E. Clapham

Article Biochemistry & Molecular Biology

Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels

Wayne I. DeHaven et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

The molecular choreography of a store-operated calcium channel

Richard S. Lewis

NATURE (2007)

Review Immunology

Calcium signalling in lymphocyte activation and disease

Stefan Feske

NATURE REVIEWS IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity

Shenyuan L. Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

M. Vig et al.

SCIENCE (2006)

Review Pharmacology & Pharmacy

Ca2+ signalling and pancreatitis:: effects of alcohol, bile and coffee

OH Petersen et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

J Liou et al.

CURRENT BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

SA Walker et al.

EMBO JOURNAL (2004)

Review Biochemistry & Molecular Biology

Calcium and fertilization: the beginning of life

L Santella et al.

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Review Multidisciplinary Sciences

Calcium signaling: A tale for all seasons

E Carafoli

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Immunology

Gene regulation mediated by calcium signals in T lymphocytes

S Feske et al.

NATURE IMMUNOLOGY (2001)

Review Cell Biology

The versatility and universality of calcium signalling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.